An Interactive Procedure for Multiobjective Analysis of Water Resources Allocation

This paper reports on part of IIASA's research concerning regional water management planning, focusing on the Western Skane region in Southern Sweden. The IIASA studies are concerned with four issues of particular importance to water resources management, namely, conflict resolution, criteria of choice, uncertainty, and institutional arrangements. This paper is related primarily to the first two of these issues. An interactive procedure seeking the satisfactory nondominated solution of the multiobjective water resources allocation problem is discussed. It is based on the Powell method with penalty function for the solution of scalar optimization problem and on a constraint and weighting method, or actually a reference objective method, for the solution of the multiobjective optimization problem. Application of the procedure is illustrated by an example referring to the situation in the Kavlinge River system in the Western Skane, Sweden

Management of Four Alfalfa Varieties to Control Damage from Potato Leafhoppers

The main purpose of this study was to obtain information on forage yield and quality of four alfalfa (Medicago sativa L.) varieties that differed in level of resistance to potato leafhopper (Empoasca fabae Harris) yellowing, when cut at three stages of growth in the second and third cuttings in field plots, with and without insecticide application. The stages of growth were bud, 1/10, and full bloom. Other purposes included study of the same varieties in field cages manually infested at 20, 40, and 60 adult leafhoppers/square yard, and in supplemental cuttings of field plots under high natural infestation levels

Child and Parent Perceptions of Participating in Multimethod Research in the Acute Aftermath of Pediatric Injury

Background: Despite growing evidence that participation in psychological trauma research is well tolerated by children and parents, ethics boards may voice concerns regarding research with families with recent acute trauma exposure. Factors impacting child and parent experiences of research participation are not well documented, particularly for methodologies including observational components. Objectives: This study describes child and parent perceptions of research participation involving an observational task following an acute traumatic event and explores potential relationships between research experience and selected demographic factors (race/ethnicity, sex, age, prior trauma exposure), and post-traumatic stress symptoms. Methods: As part of a larger study on the role of biopsychosocial factors in post-traumatic stress symptoms, 96 child–parent dyads (ages 8–12 years, M = 10.6) participated in a three–time point study following hospitalization for pediatric injury. At baseline, children and parents completed measures of reactions to research participation, post-traumatic stress symptoms, and trauma history. Measures of post-traumatic stress symptoms were repeated at 6- and 12-week follow-up assessments. Results: The majority of families reported they were glad they participated in the research study (61% children; 72% parents) and felt good about helping others (74% children; 93% parents). Negative feelings were uncommon (\u3c 10% of families). Perceptions of participation were not related to race, sex, or trauma history, but child age significantly factored into trust of the research team and informed consent (Spearman’s ρ = .289, p \u3c .01). Reactions to research were not significantly related to child or parent post-traumatic stress symptoms at any time point. Conclusions: Current results extend past research to suggest that most children’s and parents’ research experience is positive, even when completing an observational task during hospitalization for an injury. Children under the age of 10 years may perceive their participation as less voluntary, supporting prior findings that additional steps be taken to ensure their understanding of their choice in participation

EPHA2 mutations with oncogenic characteristics in squamous cell lung cancer and malignant pleural mesothelioma.

Squamous cell carcinoma (SCC) and malignant pleural mesothelioma (MPM) are thoracic malignancies with very poor prognosis and limited treatment options. It is an established fact that most of the solid tumors have overexpression of EPHA2 receptor tyrosine kinase. EPHA2 is known to exhibit opposing roles towards cancer progression. It functions in inhibiting cancer survival and migration via a ligand and tyrosine kinase dependent signaling (Y772). Whereas it is known to promote tumor progression and cell migration through a ligand-independent signaling (S897). We analyzed the expression profile and mutational status of the ephrin receptor A2 (EPHA2) in SCC and MPM cell lines and primary patient specimens. The EPHA2 receptor was found to be either overexpressed, mutated or amplified in SCC and MPM. In particular, the EPHA2 mutants A859D and T647M were interesting to explore, A859D Y772 dead mutant exhibited lower levels of phosphorylation at Y772 compared to T647M mutant. Molecular Dynamics simulations studies suggested that differential changes in conformation might form the structural basis for differences in the level of EPHA2 activation. Consequently, A859D mutant cells exhibited increased proliferation as well as cell migration compared to controls and T647M mutant. Kinomics analysis demonstrated that the STAT3 and PDGF pathways were upregulated whereas signaling through CBL was suppressed. Considered together, the present work has uncovered the oncogenic characteristics of EPHA2 mutations in SSC and MPM reinstating the dynamics of different roles of EPHA2 in cancer. This study also suggests that a combination of doxazosin and other EPHA2 inhibitors directed to inhibit the pertinent signaling components may be a novel therapeutic strategy for MPM and Non-small cell lung cancer patients who have either EPHA2 or CBL alterations

Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib

Qualitat de vida relacionada amb la salut; Olaparib; Càncer de pàncreesCalidad de vida relacionada con la salud; Olaparib, Cáncer de páncreasHealth-related quality of life; Olaparib; Pancreatic cancerBackground Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose) polymerase inhibitor, than placebo in patients with a germline BRCA1 and/or BRCA2 mutation (gBRCAm) and metastatic pancreatic cancer whose disease had not progressed during first-line platinum-based chemotherapy. The prespecified HRQoL evaluation is reported here. Patients and methods Patients were randomized to receive maintenance olaparib (300 mg b.i.d.; tablets) or placebo. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module at baseline, every 4 weeks until disease progression, at discontinuation, and 30 days after last dose. Scores ranged from 0 to 100; a ≥10-point change or difference between arms was considered clinically meaningful. Adjusted mean change from baseline was analysed using a mixed model for repeated measures. Time to sustained clinically meaningful deterioration (TSCMD) was analysed using a log-rank test. Results Of 154 randomized patients, 89 of 92 olaparib-arm and 58 of 62 placebo-arm patients were included in HRQoL analyses. The adjusted mean change in Global Health Status (GHS) score from baseline was <10 points in both arms and there was no significant between-group difference [−2.47; 95% confidence interval (CI) −7.27, 2.33; P = 0.31]. Analysis of physical functioning scores showed a significant between-group difference (−4.45 points; 95% CI −8.75, −0.16; P = 0.04). There was no difference in TSCMD for olaparib versus placebo for GHS [P = 0.25; hazard ratio (HR) 0.72; 95% CI 0.41, 1.27] or physical functioning (P = 0.32; HR 1.38; 95% CI 0.73, 2.63). Conclusions HRQoL was preserved with maintenance olaparib treatment with no clinically meaningful difference compared with placebo. These results support the observed efficacy benefit of maintenance olaparib in patients with a gBRCAm and metastatic pancreatic cancer.This study was sponsored by AstraZeneca and is part of an alliance between AstraZeneca and MSD (no grant number). This research was funded in part through the NIH/NCI Cancer Center Support Grant P30-17 CA008748

Geology of New Providence Island, Bahamas: A Field Trip Guide

See other Smith authored Field Trip Guides of Gerace Research Centre

CPN Tools 4: Multi-formalism and Extensibility

Abstract. CPN Tools is an advanced tool for editing, simulating, and analyzing colored Petri nets. This paper discusses the fourth major re-lease of the tool, which makes it simple to use the tool for ordinary Petri nets, including adding inhibitor and reset arcs, and PNML export. This version also supports declarative modeling using constraints, and adds an extension framework making it easy for third parties to extend CPN Tools using Java.

Beaver exploitation, 400,000 years ago, testifies to prey choice diversity of Middle Pleistocene hominins

Data regarding the subsistence base of early hominins are heavily biased in favor of the animal component of their diets, in particular the remains of large mammals, which are generally much better preserved at archaeological sites than the bones of smaller animals, let alone the remains of plant food. Exploitation of smaller game is very rarely documented before the latest phases of the Pleistocene, which is often taken to imply narrow diets of archaic Homo and interpreted as a striking economic difference between Late Pleistocene and earlier hominins. We present new data that contradict this view of Middle Pleistocene Lower Palaeolithic hominins: cut mark evidence demonstrating systematic exploitation of beavers, identified in the large faunal assemblage from the c. 400,000 years old hominin site Bilzingsleben, in central Germany. In combination with a prime-age dominated mortality profile, this cut mark record shows that the rich beaver assemblage resulted from repetitive human hunting activities, with a focus on young adult individuals. The Bilzingsleben beaver exploitation evidence demonstrates a greater diversity of prey choice by Middle Pleistocene hominins than commonly acknowledged, and a much deeper history of broad-spectrum subsistence than commonly assumed, already visible in prey choices 400,000 years ago.Human Origin

High field x-ray diffraction study on a magnetic-field-induced valence transition in YbInCu4

We report the first high-field x-ray diffraction experiment using synchrotron x-rays and pulsed magnetic fields exceeding 30 T. Lattice deformation due to a magnetic-field-induced valence transition in YbInCu4 is studied. It has been found that the Bragg reflection profile at 32 K changes significantly at around 27 T due to the structural transition. In the vicinity of the transition field the low-field and the high-field phases are observed simultaneously as the two distinct Bragg reflection peaks: This is a direct evidence of the fact that the field-induced valence state transition is the first order phase transition. The field-dependence of the low-field-phase Bragg peak intensity is found to be scaled with the magnetization.Comment: 5 pages, 6 figures, submitted to J. Phys. Soc. Jp