Maximal Cohen-Macaulay tensor products and vanishing of Ext modules

In this paper, we investigate the maximal Cohen-Macaulay property of tensor products of modules, and then give criteria for projectivity of modules in terms of vanishing of Ext modules. One of the applications shows that the Auslander-Reiten conjecture holds for Cohen-Macaulay normal rings.Comment: 8 page

Fundamental and higher eigenmodes of qPlus sensors with a long probe for vertical-lateral bimodal atomic force microscopy

The detection of vertical and lateral forces at the nanoscale by atomic force microscopy (AFM) reveals various mechanical properties on surfaces. The qPlus sensor is a widely used force sensor, which is built from a quartz tuning fork (QTF) and a sharpened metal probe, capable of high-resolution imaging in viscous liquids such as lubricant oils. Although a simultaneous detection technique of vertical and lateral forces by using a qPlus sensor is required in the field of nanotribology, it has still been difficult because the torsional oscillations of QTFs cannot be detected. In this paper, we propose a method to simultaneously detect vertical and lateral force components by using a qPlus sensor with a long probe. The first three eigenmodes of the qPlus sensor with a long probe are theoretically studied by solving a set of equations of motion for the QTF prong and probe. The calculation results were in good agreement with the experimental results. It was found that the tip oscillates laterally in the second and third modes. Finally, we performed friction anisotropy measurements on a polymer film by using a bimodal AFM utilizing the qPlus sensor with a long probe to confirm the lateral force detection

Hydrogen-bond-assisted isotactic-specific radical polymerization of N-vinyl-2-pyrrolidone with tartrate additives in toluene at low temperatures : high-resolution 1H NMR analysis

A diethyl L-tartrate (L-EtTar)-assisted radical polymerization of N-vinyl-2-pyrrolidone has been developed as the first reported example of the synthesis of isotactic-rich poly(N-vinyl-2-pyrrolidone) (PVP). The addition of L-EtTar in toluene at temperatures of –40°C and lower led to a significant increase in the polymer yield by one order of magnitude compared with the reaction in the absence of L-EtTar. Decreasing the polymerization temperature led to increases in the isotacticity of the PVP, with the mm triad reaching 66.4% at −93 °C. 1H NMR measurement at 920 MHz was conducted to establish a reliable strategy for quantifying the triad tacticities. High-temperature NMR measurements at 250 °C were performed using a specially-designed NMR probe, which led to dramatic narrowing of the 1H line width

Characterization of candidate intermediates in the Black Box of the ecdysone biosynthetic pathway in Drosophila melanogaster: Evaluation of molting activities on ecdysteroid-defective larvae

Early steps of the biosynthetic pathway of the insect steroid hormone ecdysone remains the “Black Box” wherein the characteristic ecdysteroid skeleton is built. 7-Dehydrocholesterol (7dC) is the precursor of uncharacterized intermediates in the Black Box. The oxidation step at C-3 has been hypothesized during conversion from 7dC to 3-oxo-2, 22, 25-trideoxyecdysone, yet 3-dehydroecdysone is undetectable in some insect species. Therefore, we first confirmed that the oxidation at C-3 occurs in the fruitfly, Drosophila melanogaster using deuterium-labeled cholesterol. We next investigated the molting activities of candidate intermediates, including oxidative products of 7dC, by feeding-rescue experiments for Drosophila larvae in which an expression level of a biosynthetic enzyme was knocked down by the RNAi technique. We found that the administration of cholesta-4, 7-dien-3-one (3-oxo-Δ4, 7C) could overcome the molting arrest of ecdysteroid-defective larvae in which the expression level of neverland was reduced. However, feeding 3-oxo-Δ4, 7C to larvae in which the expression levels of shroud and Cyp6t3 were reduced inhibited molting at the first instar stage, suggesting that this steroid could be converted into an ecdysteroid-antagonist in loss of function studies of these biosynthetic enzymes. Administration of the highly conjugated cholesta-4, 6, 8(14)-trien-3-one, oxidized from 3-oxo-Δ4, 7C, did not trigger molting of ecdysteroid-defective larvae. These results suggest that an oxidative product derived from 7dC is converted into ecdysteroids without the formation of this stable conjugated compound. We further found that the 14α-hydroxyl moiety of Δ4-steroids is required to overcome the molting arrest of larvae in loss of function studies of Neverland, Shroud, CYP6T3 or Spookier, suggesting that oxidation at C-14 is indispensable for conversion of these Δ4-steroids into ecdysteroids via 5β-reduction

Association of Pain History and Current Pain With Sagittal Spinal Alignment and Muscle Stiffness and Muscle Mass of the Back Muscles in Middle-aged and Elderly Women

[Study Design] A cross-sectional study. [Objective] To investigate the association of low back pain history (LBPH) and LBP with sagittal spinal alignment, stiffness assessed using ultrasonic shear wave elastography, and mass of the back muscle in community-dwelling middle-aged and elderly women. [Summary of Background Data] The association of LBPH and LBP with sagittal spinal alignment, stiffness, and mass of the back muscles remains unclear in middle-aged and elderly women. [Participants and Methods] The study comprised 19 asymptomatic middle-aged and elderly women [control (CTR) group], 16 middle-aged and elderly women with LBPH (LBPH group), and 23 middle-aged and elderly women with LBP (LBP group). Sagittal spinal alignment in the standing and prone positions (kyphosis angle in the thoracic spine, lordosis angle in the lumbar spine, and anterior inclination angle in the sacrum) was measured using a Spinal Mouse. The stiffness of the back muscles (lumbar erector spinae and multifidus) in the prone position was measured using ultrasonic shear wave elastography. The mass of the back muscles (thoracic and lumbar erector spinae, lumbar multifidus, and quadratus lumborum) was also measured. [Results] Multiple logistic regression analysis with a forward selection method showed that the stiffness of the lumbar multifidus muscle was a significant and independent factor of LBPH. The stiffness of the lumbar multifidus muscle was significantly higher in the LBPH group than in the CTR group. Multiple logistic regression analysis also indicated that lumbar lordosis angle in the standing position was a significant and independent factor of LBP. The lumbar lordosis angle was significantly smaller in the LBP group than in the CTR group. [Conclusions] Our results suggest that LBPH is associated with increased stiffness of the lumbar multifidus muscle in the prone position, and that LBP is associated with the decreased lumbar lordosis in the standing position in community-dwelling middle-aged and elderly women

Epitaxial contact Andreev reflection spectroscopy of NbN/Co₂FeSi layered devices

We investigated the spin polarization P of Co-based Heusler alloy Co2FeSi by epitaxial contact Andreev reflection (ECAR) spectroscopy using epitaxially grown superconductor NbN and Heusler alloy Co2FeSi layered devices. Ferromagnetic Co2FeSi possesses the highest Curie temperature (TC ? 1100 K) and the largest spontaneous magnetic moment (ps ? 6 μB) in the class of Heusler alloys. The ECAR measurements revealed that the P value of Co2FeSi was 54 ± 2% with a finite barrier parameter Z, indicating that an intrinsic P value in ECAR spectroscopy would exceed reported values in point-contact Andreev reflection spectroscopy. We therefore established not only the epitaxial integration of ferromagnetic Co2FeSi with superconductor NbN on an MgO substrate but also the fabrication and evaluation techniques of their ECAR devices. This highly versatile superconducting spintronic system enables fundamental superconducting spintronic studies, and it is also a candidate for practical superconducting spintronic devices

Evaluation of countermeasure against future malware evolution with deterministic modeling

Recently, machine learning technologies have dramatically evolved. Accordingly, the concept of self-evolving botnets has been introduced, which discover vulnerabilities of hosts by distributed machine learning using the computational resources of infected hosts, and infect other hosts by attacks using the discovered vulnerabilities. The infectability of the self-evolving botnets is too strong compared with conventional botnets, so that such new botnets will become the serious threat to future network society including 5G and IoT environments. In this paper, we consider a volunteer model that discovers unknown vulnerabilities earlier than self-evolving botnets by distributed computing using volunteer hosts’ resources and repairs the vulnerabilities. We propose deterministic modeling for the volunteer model. Through numerical calculations, we evaluate the performance of the volunteer model against self-evolving botnets.This is a product of research which was financially supported by the Kansai University Fund for Supporting Young Scholars, 2018, "Design of anti-malware systems against future malware evolution". This research was partially supported by The Telecommunications Advancement Foundation, Japan.Asia-Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC 2019), November 18-21, 2019, Lanzhou, Chin

コハツセイ スイシンケイ ナイブンピツシュヨウ ノ ゲカテキチリョウ

　Recently, new treatment guidelines and classifications were proposed for the management of pancreatic neuroendocrine tumors（P-NETs）, and are now being used in clinical practice. The World Health Organization classification published in 2010 emphasized the importance of a grading system for P-NETs based on parameters of proliferative activity, such as mitotic count and Ki-67 labeling index, proposed by the European Neuroendocrine Tumor Society. For surgical treatment of P-NETs, it is important to select a strategy based on the degree of tumor malignancy. However, there are still no clear indications for organ-preserving pancreatic resection or lymph node dissection. This article outlines the surgical management and clinicopathological features of P-NETs. There are various surgical options, such as tumor enucleation, spleen-preserving distal pancreatectomy（SpDP），distal pancreatectomy with splenectomy, pancreatoduodenectomy, and duodenumpreserving pancreatic head resection. Hepatectomy is the first choice for liver metastasis from welldifferentiated neuroendocrine carcinoma without extrahepatic metastasis. Other treatment options are radiofrequency ablation, transarterial chemoembolization/ embolization, and liver transplantation. Systematic chemotherapy, biotherapy such as somatostatin analogue and interferon-α, and targeted therapy are used for recurrence after surgery and unresectable tumors. This article also gives details of the surgical techniques available for tumor enucleation and SpDP