Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.

BackgroundThe left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes. However, no studies have examined substances other than nitric oxide that could be beneficial for the bypass conduit, native coronary artery or ischemic myocardium. This study was conducted to evaluate differences in metabolic profiles between the LITA and ascending aorta using gas chromatography-time of flight-mass spectrometry (GC-TOF-MS).MethodsTwenty patients who underwent CABG using the LITA were prospectively enrolled. Plasma samples were collected simultaneously from the LITA and ascending aorta. GC-TOF-MS based untargeted metabolomic analyses were performed and a 2-step volcano plot analysis was used to identify distinguishable markers from two plasma metabolome profiles. Semi-quantitative and quantitative analyses were performed using GC-TOF-MS and enzyme-linked immunosorbent assay, respectively, after selecting target metabolites based on the metabolite set enrichment analysis.ResultsInitial volcano plot analysis demonstrated 5 possible markers among 851 peaks detected. The final analysis demonstrated that the L-cysteine peak was significantly higher in the LITA than in the ascending aorta (fold change = 1.86). The concentrations of intermediate metabolites such as L-cysteine, L-methionine and L-cystine in the 'cysteine and methionine metabolism pathway' were significantly higher in the LITA than in the ascending aorta (2.0-, 1.4- and 1.2-fold, respectively). Quantitative analysis showed that the concentration of hydrogen sulfide (H₂S) was significantly higher in the LITA.ConclusionThe plasma metabolome profiles of the LITA and ascending aorta were different, particularly higher plasma concentrations of L-cysteine and H₂S in the LITA

Effects of Particle Size and Cement Replacement of LCD Glass Powder in Concrete

The high quality liquid crystal display (LCD) processing waste glass (LPWG) generated from the manufacturing process of Korea’s LCD industries, having the world’s highest technological level and production, was finely ground into particles smaller than cement particles (higher fineness than OPC) to verify their applicability and performance as a replacement for cement. For a concrete mix having a W/B ratio of 0.44, cement was replaced with LPWG glass powder (LGP) at ratios of 5, 10, 15, and 20% (LGP12) and 5 and 10% (LGP5) according to the particle size to prepare test cylinder specimens, which were tested with respect to air contents, slump in fresh concrete, and compressive strength and splitting tensile strength of hardened concrete. The microstructure of the concrete specimens was analyzed through Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), and a Mercury Intrusion Porosimetry (MIP). Replacement of cement with LGP for cement could effectively decrease the quantity of cement used due to the excellent performance of LGP. It may positively contribute to the sustainable development of the cement industry as well as waste recycling and environment conservation on a national scale

Metal-organic framework based on hinged cube tessellation as transformable mechanical metamaterial

Mechanical metamaterials exhibit unusual properties, such as negative Poisson???s ratio, which are difficult to achieve in conventional materials. Rational design of mechanical metamaterials at the microscale is becoming popular partly because of the advance in three-dimensional printing technologies. However, incorporating movable building blocks inside solids, thereby enabling us to manipulate mechanical movement at the molecular scale, has been a difficult task. Here, we report a metal-organic framework, self-assembled from a porphyrin linker and a new type of Zn-based secondary building unit, serving as a joint in a hinged cube tessellation. Detailed structural analysis and theoretical calculation show that this material is a mechanical metamaterial exhibiting auxetic behavior. This work demonstrates that the topology of the framework and flexible hinges inside the structure are intimately related to the mechanical properties of the material, providing a guideline for the rational design of mechanically responsive metal-organic frameworks

Phase Current Measurement Method of Dual Inverter-Motor Drive System Using a Single DC Link Current Sensor

In recent years, electric propulsion systems have become widely, used and these systems have strict limits in volume and weight. Therefore, it is necessary to reduce the weight of the inverter-motor drive system. In a typical n inverter-motor drive system, at least 2n phase current sensors are required. In order to reduce the number of phase current sensors, this paper proposes a method for measuring phase current using n DC link current sensors in a 2n inverter-motor drive system. Two phase currents per inverter-motor system are measured during one period of the switching frequency using the pulse width modulation (PWM) shift method. However, since the measured phase current contains an error component in the average current, the error component was compensated for in order to obtain a current similar to the actual phase current by using the slope and dwell time of the phase current. The effectiveness of the proposed method is verified through experiments

Hepatic Parasitic Abscess Caused by Clonorchiasis: Unusual CT Findings of Clonorchiasis

Clonorchiasis is caused by a chronic infestation of liver flukes, Clonorchis sinensis, and these reside mainly in the medium- and small-sized intrahepatic bile ducts. Therefore, diffuse, uniform, minimal or mild dilatation of these bile ducts, particularly in the periphery, without dilatation of the extrahepatic bile duct is the typical finding on several imaging modalities. We report here on the CT findings of an unusual case of hepatic parasitic abscess that was caused by clonorchiasis; this malady mimicked cholangiocarcinoma, and there was no dilatation of the intrahepatic bile ducts

COMBUSTION CHARACTERISTICS AND EMISSION OF HAZARDOUS AIR POLLUTANTS IN COMMERCIAL FLUIDIZED BED COMBUSTORS FOR SEWAGE SLUDGE

Since the disposal of sewage sludge in ocean has been prohibited recently according to London Dumping Convention, technological need for treating sewage sludge safely and efficiently are getting increased in Korea. FBC (Fluidized Bed Combustor) technology has been selected and utilized as one of the alternatives because of combustible content in sludge, on-going process development to maintain the best combustion efficiency, and good heat recovery for energy utilization. In this paper, the process and combustion characteristics of commercially operating FBC incineration plants with the capacity ranging from 50 – 150 tons of sludge per day were investigated by comparing emission data from 4 different plants. Concentrations of hazardous gaseous pollutants (HAPs) such as fine particulate matter, heavy metals, and dioxin from sludge combustion before and after air pollution control devices were measured and analyzed at commercial operating conditions of one typical incinerator. Most of emission data at stack showed under the environmental regulatory limits. Mercury and some heavy metals emission have been reduced significantly as co-beneficial effect since the air pollution control configuration was well arranged and installed to control the regulatory gases such as NOx, SO2, particulates, and dioxin. Sludge, especially generated from industrial plants, contained measurable amounts of acidic materials and heavy metals including Hg. Therefore, such metal emission should receive an attention by monitoring them and further mass balance study for better understanding their fates in the process must proceed in future