12,635 research outputs found
Surface-hopping dynamics and decoherence with quantum equilibrium structure
In open quantum systems decoherence occurs through interaction of a quantum
subsystem with its environment. The computation of expectation values requires
a knowledge of the quantum dynamics of operators and sampling from initial
states of the density matrix describing the subsystem and bath. We consider
situations where the quantum evolution can be approximated by quantum-classical
Liouville dynamics and examine the circumstances under which the evolution can
be reduced to surface-hopping dynamics, where the evolution consists of
trajectory segments evolving exclusively on single adiabatic surfaces, with
probabilistic hops between these surfaces. The justification for the reduction
depends on the validity of a Markovian approximation on a bath averaged memory
kernel that accounts for quantum coherence in the system. We show that such a
reduction is often possible when initial sampling is from either the quantum or
classical bath initial distributions. If the average is taken only over the
quantum dispersion that broadens the classical distribution, then such a
reduction is not always possible.Comment: 11, pages, 8 figure
Three Dimensional Structure and Energy Balance of a Coronal Mass Ejection
The Ultraviolet Coronagraph Spectrometer (UVCS) observed Doppler shifted
material of a partial Halo Coronal Mass Ejection (CME) on December 13 2001. The
observed ratio of [O V]/O V] is a reliable density diagnostic important for
assessing the state of the plasma. Earlier UVCS observations of CMEs found
evidence that the ejected plasma is heated long after the eruption. We have
investigated the heating rates, which represent a significant fraction of the
CME energy budget. The parameterized heating and radiative and adiabatic
cooling have been used to evaluate the temperature evolution of the CME
material with a time dependent ionization state model. The functional form of a
flux rope model for interplanetary magnetic clouds was also used to
parameterize the heating. We find that continuous heating is required to match
the UVCS observations. To match the O VI-bright knots, a higher heating rate is
required such that the heating energy is greater than the kinetic energy. The
temperatures for the knots bright in Ly and C III emission indicate
that smaller heating rates are required for those regions. In the context of
the flux rope model, about 75% of the magnetic energy must go into heat in
order to match the O VI observations. We derive tighter constraints on the
heating than earlier analyses, and we show that thermal conduction with the
Spitzer conductivity is not sufficient to account for the heating at large
heights.Comment: 40 pages, 16 figures, accepted for publication in ApJ For associated
mpeg file, please see https://www.cora.nwra.com/~jylee/mpg/f5.mp
Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation
The proteome contains hundreds of proteins that in theory could be excellent therapeutic targets for the treatment of human diseases. However, many of these proteins are from functional classes that have never been validated as viable candidates for the development of small molecule inhibitors. Thus, to exploit fully the potential of the Human Genome Project to advance human medicine, there is a need to develop generic methods of inhibiting protein activity that do not rely on the target protein’s function. We previously demonstrated that a normally stable protein, methionine aminopeptidase-2 or MetAP-2, could be artificially targeted to an Skp1-Cullin-F-box (SCF) ubiquitin ligase complex for ubiquitination and degradation through a chimeric bridging molecule or Protac (proteolysis targeting chimeric molecule). This Protac consisted of an SCFß-TRCP-binding phosphopeptide derived from I{kappa}B{alpha} linked to ovalicin, which covalently binds MetAP-2. In this study, we employed this approach to target two different proteins, the estrogen (ER) and androgen (AR) receptors, which have been implicated in the progression of breast and prostate cancer, respectively. We show here that an estradiol-based Protac can enforce the ubiquitination and degradation of the {alpha} isoform of ER in vitro, and a dihydroxytestosterone-based Protac introduced into cells promotes the rapid disappearance of AR in a proteasome-dependent manner. Future improvements to this technology may yield a general approach to treat a number of human diseases, including cancer
Novel SOFC Anodes for the Direct Electrochemical Oxidation of Hydrocarbon
This paper describes recent developments in solid-oxide fuel cells (SOFC) that use Cu-based cermets as the anode for direct oxidation of hydrocarbon fuels, including liquids such as gasoline, to generate electrical power without the need for first reforming that fuel to H2. Cu-YSZ cermets were found to be stable in hydrocarbon environments, but exhibited low performance for direct oxidation. Reasonable power densities could only be achieved with the addition of a catalytic oxide, like ceria, with the Cu cermet. Electrochemical oxidation studies demonstrated that the initial products for reaction depend on the catalytic oxide. Finally, the effect of sulfur impurities in the fuel is discussed
Far-ultraviolet Emission-line Morphologies of the Supernova Remnant G65.3+5.7
We present the first far-ultraviolet (FUV) emission-line morphologies of the
whole region of the supernova remnant (SNR) G65.3+5.7 using the FIMS/SPEAR
data. The morphologies of the C IV {\lambda}{\lambda}1548, 1551, He II
{\lambda}1640, and O III] {\lambda}{\lambda}1661, 1666 lines appear to be
closely related to the optical and/or soft X-ray images obtained in previous
studies. Dramatic differences between the C IV morphology and the optical [O
III] {\lambda}5007 image provide clues to a large resonant-scattering region
and a foreground dust cloud. The FUV morphologies also reveal the overall
distribution of various shocks in different evolutionary phases and an
evolutionary asymmetry between the east and the southwest sides in terms of
Galactic coordinates, possibly due to a Galactic density gradient in the global
scale. The relative X-ray luminosity of G65.3+5.7 to C IV luminosity is
considerably lower than those of the Cygnus Loop and the Vela SNRs. This
implies that G65.3+5.7 has almost evolved into the radiative stage in the
global sense and supports the previous proposal that G65.3+5.7 has lost its
bright X-ray shell and become a member of mixed-morphology SNRs as it has
evolved beyond the adiabatic stage.Comment: 6 pages, 3 figures, accepted for publication in The Ap
SOFC Anodes Based on Infiltration of La\u3csub\u3e0.3\u3c/sub\u3eSr\u3csub\u3e0.7\u3c/sub\u3eTiO\u3csub\u3e3\u3c/sub\u3e
Composites formed by infiltration of 45 wt % La0.3Sr0.7TiO3 (LST) into 65% porous yttria-stabilized zirconia (YSZ) were examined for application as solid oxide fuel cell (SOFC) anodes. Although LST does not react with YSZ, the structure of the LST deposits was strongly affected by the calcination temperature. At 1373 K, the LST formed loosely packed, 0.1 µm particles that filled the YSZ pores. The conductivity of this composite depended strongly on the pretreatment conditions but was greater than 0.4 S/cm after heating to 1173 K in humidified (3% H2O)H2. Following calcination at 1573 K, the LST had sintered significantly, decreasing the conductivity of the composite by a factor of approximately 5. The addition of a catalyst was critical for achieving reasonable electrochemical performance, with the addition of 0.5 wt % Pd and 5 wt % ceria increasing the power density of otherwise identical cells from less than 20 to 780 mW/cm2 for operation in humidified (3% H2O)H2 at 1073 K. Electrodes prepared from LST deposits calcined at 1373 K were found to exhibit a much better performance than those prepared from LST deposits calcined at 1573 K, demonstrating that the structure of the composite is critical for achieving high performance
- …