Northern Saw-whet Owls: Rare or Overlooked? An Example from the Central Platte Valley

Assessing the population status for species requires accurate measures of local or regional numbers. For many species, standardized protocols exist for estimating local numbers through visual counts (e.g., Breeding Bird Survey routes, Christmas Bird Count circles, and point count protocols used by the US Forest Service). For many raptor species, monitoring populations at migratory bottlenecks such as the Goshute Mountains, NV, Hawk Mountain, PA, and Cape May, NJ, provide yearly indices of population health. Unfortunately, most monitoring protocols overlook a suite of small crepuscular or nocturnal species. Project Owlnet (www.projectowlnet.org) is a volunteer-based network of banding stations focusing on Northern Saw-whet Owl (Aegolius acadicus) migration in the eastern part of the United States and Canada. Information collected by Project Owlnet volunteer groups reveals that this small owl appears to be far more common than previously thought

Optimizing human pulmonary perfusion measurement using an in silico model of arterial spin labeling magnetic resonance imaging.

Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is an imaging methodology that uses blood as an endogenous contrast agent to quantify flow. One limitation of this method of capillary blood quantification when applied in the lung is the contribution of signals from non-capillary blood. Intensity thresholding is one approach that has been proposed for minimizing the non-capillary blood signal. This method has been tested in previous in silico modeling studies; however, it has only been tested under a restricted set of physiological conditions (supine posture and a cardiac output of 5 L/min). This study presents an in silico approach that extends previous intensity thresholding analysis to estimate the optimal "per-slice" intensity threshold value using the individual components of the simulated ASL signal (signal arising independently from capillary blood as well as pulmonary arterial and pulmonary venous blood). The aim of this study was to assess whether the threshold value should vary with slice location, posture, or cardiac output. We applied an in silico modeling approach to predict the blood flow distribution and the corresponding ASL quantification of pulmonary perfusion in multiple sagittal imaging slices. There was a significant increase in ASL signal and heterogeneity (COV = 0.90 to COV = 1.65) of ASL signals when slice location changed from lateral to medial. Heterogeneity of the ASL signal within a slice was significantly lower (P = 0.03) in prone (COV = 1.08) compared to in the supine posture (COV = 1.17). Increasing stroke volume resulted in an increase in ASL signal and conversely an increase in heart rate resulted in a decrease in ASL signal. However, when cardiac output was increased via an increase in both stroke volume and heart rate, ASL signal remained relatively constant. Despite these differences, we conclude that a threshold value of 35% provides optimal removal of large vessel signal independent of slice location, posture, and cardiac output

Inhibition of Lithium-Sensitive Phosphatase BPNT-1 Causes Selective Neuronal Dysfunction in C. elegans

Lithium has been a mainstay for the treatment of bipolar disorder, yet the molecular mechanisms underlying its action remain enigmatic. Bisphosphate 3′-nucleotidase (BPNT-1) is a lithium-sensitive phosphatase that catalyzes the breakdown of cytosolic 3′-phosphoadenosine 5′-phosphate (PAP), a byproduct of sulfation reactions utilizing the universal sulfate group donor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) [1–3]. Loss of BPNT-1 leads to the toxic accumulation of PAP in yeast and non-neuronal cell types in mice [4, 5]. Intriguingly, BPNT-1 is expressed throughout the mammalian brain [4], and it has been hypothesized that inhibition of BPNT-1 could contribute to the effects of lithium on behavior [5]. Here, we show that loss of BPNT-1 in Caenorhabditis elegans results in the selective dysfunction of two neurons, the bilaterally symmetric pair of ASJ chemosensory neurons. As a result, BPNT-1 mutants are defective in behaviors dependent on the ASJ neurons, such as dauer exit and pathogen avoidance. Acute treatment with lithium also causes dysfunction of the ASJ neurons, and we show that this effect is reversible and mediated specifically through inhibition of BPNT-1. Finally, we show that the selective effect of lithium on the nervous system is due in part to the limited expression of the cytosolic sulfotransferase SSU-1 in the ASJ neuron pair. Our data suggest that lithium, through inhibition of BPNT-1 in the nervous system, can cause selective toxicity to specific neurons, resulting in corresponding effects on behavior of C. elegans.National Institutes of Health (U.S.) (Grant GM084477

Use of administrative claims data for comparative effectiveness research of rheumatoid arthritis treatments

Observational studies, particularly those using large administrative claims databases, have become increasingly popular sources of comparative effectiveness or comparative safety research. Studies using claims data often face challenges and criticisms due to the lack of certain clinical information, such as lifestyle risk factors, disease severity, and questionable accuracy of disease diagnoses. A novel, claims-based algorithm to evaluate the clinical effectiveness of rheumatoid arthritis medications has been developed and its performance seems promising, although further validation is needed

Orbital-selective confinement effect of Ru 4d4d orbitals in SrRuO3_3 ultrathin film

The electronic structure of SrRuO$_3$ thin film with thickness from 50 to 1 unit cell (u.c.) is investigated via the resonant inelastic x-ray scattering (RIXS) technique at the O K-edge to unravel the intriguing interplay of orbital and charge degrees of freedom. We found that orbital-selective quantum confinement effect (QCE) induces the splitting of Ru $4d$ orbitals. At the same time, we observed a clear suppression of the electron-hole continuum across the metal-to-insulator transition (MIT) occurring at the 4 u.c. sample. From these two clear observations we conclude that QCE gives rise to a Mott insulating phase in ultrathin SrRuO$_3$ films. Our interpretation of the RIXS spectra is supported by the configuration interaction calculations of RuO$_6$ clusters.Comment: 7 pages, 7 figure

Spectroscopic Confirmation of Multiple Red Galaxy-Galaxy Mergers in MS1054-03 (z=0.83)

We present follow-up spectroscopy of the galaxy cluster MS1054-03 (z=0.83) confirming that at least six of the nine merging galaxy pairs identified by van Dokkum et al. (1999) are indeed bound systems: they have projected separations of R_s<10 kpc and relative line-of sight velocities of dv<165 km/s. For the remaining three pairs, we were unable to obtain redshifts of both constituent galaxies. To identify a more objective sample of merging systems, we select bound red galaxy pairs (R_s<=30 kpc, dv<=300 km/s) from our sample of 121 confirmed cluster members: galaxies in bound red pairs make up 15.7+/-3.6% of the cluster population. The (B-K_s) color-magnitude diagram shows that the pair galaxies are as red as the E/S0 members and have a homogeneous stellar population. The red pair galaxies span a large range in luminosity and internal velocity dispersion to include some of the brightest, most massive members (L>L*, sigma>200 km/s); these bound galaxy pairs must evolve into E/S0 members by z~0.7. These results combined with MS1054's high merger fraction and reservoir of likely future mergers indicates that most, if not all, of its early-type members evolved from (passive) galaxy-galaxy mergers at z<~1.Comment: accepted by ApJ Letters; high resolution version of Fig. 2 available at http://www.exp-astro.phys.ethz.ch/tran/outgoing/ms1054mgrs.ps.g

Bisphosphonates and risk of atrial fibrillation: a meta-analysis

Abstract Introduction Bisphosphonates are the most commonly used drugs for the prevention and treatment of osteoporosis. Although a recent FDA review of the results of clinical trials reported no clear link between bisphosphonates and serious or non-serious atrial fibrillation (AF), some epidemiologic studies have suggested an association between AF and bisphosphonates. Methods We conducted a meta-analysis of non-experimental studies to evaluate the risk of AF associated with bisphosphonates. Studies were identified by searching MEDLINE and EMBASE using a combination of the Medical Subject Headings and keywords. Our search was limited to English language articles. The pooled estimates of odds ratios (OR) as a measure of effect size were calculated using a random effects model. Results Seven eligible studies with 266,761 patients were identified: three cohort, three case-control, and one self-controlled case series. Bisphosphonate exposure was not associated with an increased risk of AF [pooled multivariate OR 1.04, 95% confidence interval (CI) 0.92-1.16] after adjusting for known risk factors. Moderate heterogeneity was noted (I-squared score = 62.8%). Stratified analyses by study design, cohort versus case-control studies, yielded similar results. Egger's and Begg's tests did not suggest an evidence of publication bias (P = 0.90, 1.00 respectively). No clear asymmetry was observed in the funnel plot analysis. Few studies compared risk between bisphosphonates or by dosing. Conclusions Our study did not find an association between bisphosphonate exposure and AF. This finding is consistent with the FDA's statement