Addiction to RUNX in lymphoma

No abstract available

The detection of irreparable mutants in Neurospora

The detection of irreparable mutants in Neurospor

Using personal construct methodology to explore relationships with adolescents with autism spectrum disorder

Background: Research shows that adolescents with Autism Spectrum Disorder (ASD) experience difficulties developing friendships, and that loneliness is a significant factor contributing to higher incidence of anxiety and depression within this population. Aims: This study aimed to provide an in-depth analysis of relationships as described by adolescents with ASD, and, from these descriptions, to explore what can be inferred about the development of successful interpersonal relationships for these individuals. Methods and Procedure: Eight adolescents with ASD participated in semi-structured interviews using established personal construct theory (PCT) techniques. Outcomes and Results: PCT was found to be a helpful approach to elicit rich, qualitative data. A thematic analysis identified four themes: relationships as a source of support, perceptions of similarity and difference, valued qualities in self and others, and the development and maintenance of relationships. Conclusions and Implications: Whilst this exploratory study highlighted some commonality in terms of perceptions of family support and friendships as protective and desirable, participants differed in their ability to establish and maintain peer relationships. Participants valued personal qualities such as intelligence, humour and trust within relationships, and recognised the important role of peers and siblings in the development of social skills, a finding which has implications for the delivery of social skills training and other interventions. The study provides empirical support for the application of personal construct methodologies in ASD research and offers a potentially useful approach to therapeutic intervention

Closing the Gap Between Theory and Practice: Teacher Beliefs, Instructional Decisions and Critical Thinking

Before beginning first grade, Matthew was a child who just loved books. He could already read some familiar books and composed his own stories and poems. He read his compositions to anyone willing to listen, which included the family dog

Response of two loci to interaction treatment

Response of two loci to interaction treatmen

Differences in dose-effect curves for UV-induced reverse mutations at two different loci

Differences in dose-effect curves for UV-induced reverse mutations at two different loc

The state of fundraising within the nonprofit social service sector : a study to determine how and to what levels of success South African NPOs are managing and operating their fundraising functions

This study sought analyse the state of fundraising within the South African nonprofit social service sector at the end of the 2007/2008 financial year. The overall aim of the study was to evaluate the fundraising capacities of social service organisations, in order to ascertain whether organisations were proficient in their fundraising-related activities

Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis

The human genome displays a rich fossil record of past gamma-retrovirus infections, yet no current epidemic is evident, despite environmental exposure to viruses that infect human cells in vitro. Feline leukemia viruses (FeLVs) rank high on this list, but domestic or workplace exposure has not been associated with detectable serological responses. Non-specific inactivation of gamma-retroviruses by serum factors appears insufficient to explain these observations. To investigate further we explored the susceptibility of primary and established human cell lines to FeLV-B, the most likely zoonotic variant. Fully permissive infection was common in cancer-derived cell lines, but was also a feature of non-transformed keratinocytes and lung fibroblasts. Cells of haematopoietic origin were less generally permissive and formed discrete groups on the basis of high or low intracellular protein expression and virion release. Potent repression was observed in primary human blood mononuclear cells and a subset of leukemia cell lines. However, the early steps of reverse transcription and integration appear to be unimpaired in non-permissive cells. FeLV-B was subject to G->A hypermutation with a predominant APOBEC3G signature in partially permissive cells but was not mutated in permissive cells or in non-permissive cells that block secondary viral spread. Distinct cellular barriers that protect primary human blood cells are likely to be important in protection against zoonotic infection with FeLV