Self-Assembly of Coordination Polymers

近年来，配位聚合物的自组装研究备受关注。它们在非线性光学、分子磁体、气体吸附、荧光等新型材料以及分子识别、多相催化等领域显示出诱人的应用前景。其中，热点课题—手性配位聚合物自发拆分现象的研究不但对于探讨生命同手性起源具有重要意义，而且在手性识别和不对称催化领域有着潜在的应用价值。本文首次合成了两种含有21螺旋链结构的配位聚合物[Ag(pyta)]n(1)和[Ag(prta)]n(2)。晶体结构分析结果表明，1和2中的银离子都是扭曲的四面体配位，pyta-和prta-均贡献出其N-O-S配位原子，其配位模式都是在文献中罕见的。所不同的是pyta-为四齿配体，化合物1为二维结构，产物是外消旋的配位...Self－assembly of coordination polymers has attracted much attention because of their remarkable applications to various fields such as nonlinear optical (NLO) materials, molecular magnets, gas absorption, fluorescent materials, as well as heterogeneous catalysis. Recently, the spontaneous resolution of chiral coordination polymers has become one of the hottest topics discussed by scientists from d...学位：理学硕士院系专业：化学化工学院化学系_无机化学学号：20012500

Assessment of CFTR function in homozygous R117H-7T subjects

Background: R117H is a frequent missense mutation included in most CFTR mutation panels. However knowledge about the residual function of R117H-CFTR channels in cystic fibrosis-affected organs, e.g. airways, intestines and sweat glands is presently lacking. Methods: We evaluated clinical CF symptoms and assessed CFTR function by sweat tests, nasal potential difference and intestinal current measurements in 2 homozygous R117H individuals (7T variant). Results: The CFTR activity in airways and intestine was within the normal range. However both individuals presented with a borderline sweat test and the male patient was infertile. Conclusions: The lack of impact of the R117H mutation on chloride secretion in intestine and nose contrasts with the similar to 80% loss of CFTR activity reported in patch clamp studies. Apparently CFTR activity is not rate-limiting for chloride secretion in both tissues at levels >20% of normal, or compensatory factors may operate that are absent in heterologous host cells in vitro. (C) 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved