Optical Polarization of 52 Radio-Loud QSOs and BL Lac Objects

Polarization measurements are presented for 52 radio-loud QSOs and BL Lac objects. For 9 highly polarized (p >3%) AGN, these are the first published polarization measurements. Of these 9, 7 are highly-polarized QSOs (HPQs), one is a BL Lac object and another is a likely BL Lac object. Polarization variability is confirmed for some of these new and previously known highly-polarized AGN. While 6 of the HPQs have flat radio spectra are almost certainly blazars, PKS 1452-217 is probably a new member of the rare class of radio-loud QSOs that show high polarization by scattering, and is therefore important for testing orientation Unified Schemes. In competition for the highest redshift HPQ are the well-observed QSO PKS 0438-43 at z = 2.85, with maximum p = 4.7%, and PKS 0046-315 at z = 2.72, for which we find p = 13%.Comment: 6 pages. Astronomical Journal, in pres

Visualizing and quantitating the spatiotemporal regulation of Ras/ERK signaling by dual-specificity mitogen-activated protein phosphatases (MKPs)

The spatiotemporal regulation of the Ras/ERK pathway is critical in determining the physiological and pathophysiological outcome of signaling. Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (DUSPs or MKPs) are key regulators of pathway activity and may also localize ERK to distinct subcellular locations. Here we present methods largely based on the use of high content microscopy to both visualize and quantitate the subcellular distribution of activated (p-ERK) and total ERK in populations of mouse embryonic fibroblasts derived from mice lacking DUSP5, a nuclear ERK-specific MKP. Such methods in combination with rescue experiments using adenoviral vectors encoding wild-type and mutant forms of DUSP5 have allowed us to visualize specific defects in ERK regulation in these cells thus confirming the role of this phosphatase as both a nuclear regulator of ERK activity and localization.</p

Evolution of the Dust Coma in Comet 67P/Churyumov-Gerasimenko Before 2009 Perihelion

Comet 67P/Churyumov-Gerasimenko is the main target of ESA's Rosetta mission and will be encountered in May 2014. As the spacecraft shall be in orbit the comet nucleus before and after release of the lander {\it Philae}, it is necessary necessary to know the conditions in the coma. Study the dust environment, including the dust production rate and its variations along its preperihelion orbit. The comet was observed during its approach to the Sun on four epochs between early-June 2008 and mid-January 2009, over a large range of heliocentric distances that will be covered by the mission in 2014. An anomalous enhancement of the coma dust density was measured towards the comet nucleus. The scalelength of this enhancement increased with decreasing heliocentric distance of the comet. This is interpreted as a result of an unusually slow expansion of the dust coma. Assuming a spherical symmetric coma, the average amount of dust as well as its ejection velocity have been derived. The latter increases exponentially with decreasing heliocentric distance (\rh), ranging from about 1 m/s at 3 AU to about 25-35 m/s at 1.4 AU. Based on these results we describe the dust environment at those nucleocentric distances at which the spacecraft will presumably be in orbit. Astronomy and Astrophysics, in pressComment: 5 pages, 4 figure

Combined BIMA and OVRO observations of comet C/1999 S4 (LINEAR)

We present results from an observing campaign of the molecular content of the coma of comet C/1999 S4 (LINEAR) carried out jointly with the millimeter-arrays of the Berkeley-Illinois-Maryland Association (BIMA) and the Owens Valley Radio Observatory (OVRO). Using the BIMA array in autocorrelation (`single-dish') mode, we detected weak HCN J=1-0 emission from comet C/1999 S4 (LINEAR) at 14 +- 4 mK km/s averaged over the 143" beam. The three days over which emission was detected, 2000 July 21.9-24.2, immediately precede the reported full breakup of the nucleus of this comet. During this same period, we find an upper limit for HCN 1-0 of 144 mJy/beam km/s (203 mK km/s) in the 9"x12" synthesized beam of combined observations of BIMA and OVRO in cross-correlation (`imaging') mode. Together with reported values of HCN 1-0 emission in the 28" IRAM 30-meter beam, our data probe the spatial distribution of the HCN emission from radii of 1300 to 19,000 km. Using literature results of HCN excitation in cometary comae, we find that the relative line fluxes in the 12"x9", 28" and 143" beams are consistent with expectations for a nuclear source of HCN and expansion of the volatile gases and evaporating icy grains following a Haser model.Comment: 18 pages, 3 figures. Uses aastex. AJ in pres

Historic Light Curve and Long-term Optical Variation of BL Lacertae 2200+420

In this paper, historical optical(UBVRI) data and newly observed data from the Yunnan Observatory of China(about100 years) are presented for BL Lacertae. Maximum variations in UBVRI: 5.12, 5.31, 4.73, 2.59, and 2.54 and color indices of U-B = -0.11 +/- 0.20, B-V= 1.0 +/- 0.11, V-R= 0.73 +/- 0.19, V-I= 1.42 +/- 0.25, R-I= 0.82 +/- 0.11, and B-I= 2.44 +/- 0.29 have been obtained from the literature; The Jurkevich method is used to investigate the existence of periods in the B band light curve, and a long-term period of 14 years is found. The 0.6 and 0.88 year periods reported by Webb et al.(1988) are confirmed. In addition, a close relation between B-I and B is found, suggesting that the spectra flattens when the source brightens.Comment: 21 pages, 6 figures, 2 table, aasms4.sty, to be published in ApJ, Vol. 507, 199

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is de-regulated in a variety of cancers due to mutations in receptor tyrosine kinases (RTKs), negative regulators of RAS (such as NF1) and core pathway components themselves (RAS, BRAF, CRAF, MEK1 or MEK2). This has driven the development of a variety of pharmaceutical agents to inhibit RAF-MEK1/2-ERK1/2 signalling in cancer and both RAF and MEK inhibitors are now approved and used in the clinic. There is now much interest in targeting at the level of ERK1/2 for a variety of reasons. First, since the pathway is linear from RAF-to-MEK-to-ERK then ERK1/2 are validated as targets per se. Second, innate resistance to RAF or MEK inhibitors involves relief of negative feedback and pathway re-activation with all signalling going through ERK1/2, validating the use of ERK inhibitors with RAF or MEK inhibitors as an up-front combination. Third, long-term acquired resistance to RAF or MEK inhibitors involves a variety of mechanisms (KRAS or BRAF amplification, MEK mutation, etc.) which re-instate ERK activity, validating the use of ERK inhibitors to forestall acquired resistance to RAF or MEK inhibitors. The first potent highly selective ERK1/2 inhibitors have now been developed and are entering clinical trials. They have one of three discrete mechanisms of action - catalytic, "dual mechanism" or covalent - which could have profound consequences for how cells respond and adapt. In this review we describe the validation of ERK1/2 as anti-cancer drug targets, consider the mechanism of action of new ERK1/2 inhibitors and how this may impact on their efficacy, anticipate factors that will determine how tumour cells respond and adapt to ERK1/2 inhibitors and consider ERK1/2 inhibitor drug combinations

Ammonia and other parent molecules in comet 10P/Tempel 2 from Herschel/HIFI and ground-based radio observations

The Jupiter-family comet 10P/Tempel 2 was observed during its 2010 return with the Herschel Space Observatory. We present here the observation of the (J, K) = (1, 0)-(0, 0) transition of ammonia at 572 GHz in this comet with the Heterodyne Instrument for the Far Infrared (HIFI) of Herschel. We also report on radio observations of other molecules (HCN, CH3OH, H2S and CS) obtained during the 1999 return of the comet with the CSO telescope and the JCMT, and during its 2010 return with the IRAM 30-m telescope. Molecular abundances relative to water are 0.09%, 1.8%, 0.4%, and 0.08% for HCN, CH3OH, H2S, and CS, respectively. An abundance of 0.5% for NH3 is obtained, which is similar to the values measured in other comets. The hyperfine structure of the ammonia line is resolved for the first time in an astronomical source. Strong anisotropy in the outgassing is present in all observations from 1999 to 2010 and is modelled to derive the production rates.Comment: 6 pages and 8 figures. Accepted for publication in Astronomy & Astrophysic

Exploring the feasibility of using Participatory Action Research (PAR) as a mechanism for school culture change to improve mental health

Adolescence is a key time to prevent or reduce poor mental health outcomes. Supportive school environments play an important role in this, and the concept of health-promoting schools have been supported globally. Participatory action research (PAR) combines theory, practice, action, and reflection by developing practical solutions to address concerns and issues within communities. Running four PAR groups across three secondary schools, we explored the feasibility of using the approach as a mechanism for bringing about culture change and improving mental health. We undertook interviews and focus groups with students (n = 24), school staff (n = 11), facilitators (n = 3), and parents/carers (n = 2). Findings are organised under five key headings: 1) Establishing PAR groups, and the PAR cycle; 2) PAR group impact; 3) Facilitators of PAR success; 4) Barriers to PAR success; 5) Future recommendations. This study demonstrated the feasibility of PAR as a tool to improve school culture. Students participating in PAR were engaged, passionate, and motivated to influence and transform school culture to improve mental health. Future research should aim to trial the PAR approach on a larger scale, to determine whether the barriers and facilitators of PAR success identified here are relevant and transferable to schools in other contexts, and to measure the impact of such initiatives on mental health outcomes