Some Acoustical Considerations in the Design of the Contemporary Organ Case

This paper discusses the historical roots, placement, shape, and materials and methods in the construction of the contemporary organ case. James W. Kibbie explores the acoustical considerations of its design and how these are reflected in the finished product

‘You have to change, the curriculum stays the same’: decoloniality and curricular justice in South African higher education

This article reports on a study that focuses on students from rural areas of South Africa and their experiences of higher education. These students have attracted little attention in widening participation research in South Africa, despite being one of the most marginalised groups. The article, drawing on the experiences of student co-researchers and using the concepts of decoloniality and curricular justice as a theoretical framework, argues for greater acknowledgement of epistemic reciprocity in curriculum development as a way to ensure more socially just curricula. Findings illustrate the importance that students attribute to being able to relate to curricula that reflect their experiences, curricula that they rarely experience in higher education. Students report feelings of marginalisation, lack of recognition of the importance of knowledge and skills developed in their communities and their relevance to higher education together with the challenges they face accessing and engaging with the curriculum.</p

A legal analysis of Australian criminal cases involving defendants with autism spectrum disorder charged with online sexual offending

This paper examines how the symptomology of the small number of individuals with autism spectrum disorder (ASD) charged with online sexual offenses in Australia is established during legal arguments and conceived by the judiciary to impact legal liability and offending behavior. This study aims to provide empirical support for the proposition that judicial discourses regarding the connection between ASD and online sexual offending, including conduct related to child exploitation material (CEM), have little bearing on overall questions of criminal liability or the use of alternative penal dispositions. It does so by exploring a sample of nine recent Australian criminal cases, involving ten rulings, that examine how evidence of ASD is raised in legal arguments in ways that suggest a diagnosed condition may have contributed significantly to the alleged wrongdoing. We conclude by suggesting current Australian judicial practice requires more sensitivity to the impact of clinical factors associated with ASD in shaping alternative supervisory and non-custodial dispositions for individuals convicted of online sexual offenses. Previous article in issu

Exploration of Endothelial Cell Directed Innate Immunity in Leprosy

As an initial point of contact with circulating innate immune precursor cells, the endothelium is poised to deliver instructive signals that influence innate immune cell activation and differentiation. In an attempt to study the endothelial innate immune interaction during an inflammatory state we developed a novel bioassay that identified activated endothelium by its capacity to trigger macrophage inflammatory protein 1 beta (MIP1b from primary monocytes. After screening a small molecule library consisting of 642 compounds, we identified two structurally unique chemical families that were able to specifically activate the endothelium. Structure-function analysis combined with transcriptional profiling identified inflammatory gene networks induced exclusively by the active compounds and allowed us to further identify important regulators of endothelial activation.With the discovery of these unique endothelial activators we sought to further characterize the CD209 positive macrophage populations arising from this interaction. As seen in human leprosy, a stark spatial distribution of CD209 positive macrophage (MF) subsets islinked to the fate of the host and pathogen. We recapitulated divergent CD209 positive MF subsets through primary cell co-culture phenotypic screens, identifying perturbations that licensed the endothelial microenvironment to skew monocytes towards the CD209 positive and CD163 negative MF; subset that is equipped for host defense. Transcriptional profiling of endothelial cells polarized by these structurally diverse activators revealed a subset of mutually regulated genes, and integration with the transcriptome profiles from leprosy lesions led to the discovery that jagged1 (JAG1) expression strongly correlates with the spatial distribution of CD209 positive MF; subsets at the site of disease. These findings suggest that soluble JAG1 may facilitate antimycobacterial human innate immune responses

Currently Mandated Myopia of Rule 10b-5: Pay No Attention to That Manager behind the Mutual Fund Curtain, The

This Article examines the current state of the Rule 10b-5 right of action following a constricting trilogy of Supreme Court cases that have rendered it a myopic remnant of the right previously endorsed by the United States Securities and Exchange Commission (the “SEC”) and hundreds of courts over a span of numerous decades. The Roberts Court’s pronouncement in Janus Capital Group, Inc. v. First Derivative Traders has generated an immense amount of criticism and a slew of conflicting lower court decisions. By effectively abolishing most private Rule 10b-5 claims against secondary actors, including lawyers, accountants, credit rating agencies, underwriters and securities analysts, and by mistakenly including mutual fund investment managers in the class of ordinary secondary actors, the Court has chosen a short-sighted, ill-reasoned standard that ignores the doctrinal foundations of the Securities Exchange Act of 1934 (the 1934 Act ), as well as the practical realities and traditional bases of mutual fund law and practice

Exploration of Endothelial Cell Directed Innate Immunity in Leprosy

As an initial point of contact with circulating innate immune precursor cells, the endothelium is poised to deliver instructive signals that influence innate immune cell activation and differentiation. In an attempt to study the endothelial innate immune interaction during an inflammatory state we developed a novel bioassay that identified activated endothelium by its capacity to trigger macrophage inflammatory protein 1 beta (MIP1b from primary monocytes. After screening a small molecule library consisting of 642 compounds, we identified two structurally unique chemical families that were able to specifically activate the endothelium. Structure-function analysis combined with transcriptional profiling identified inflammatory gene networks induced exclusively by the active compounds and allowed us to further identify important regulators of endothelial activation.With the discovery of these unique endothelial activators we sought to further characterize the CD209 positive macrophage populations arising from this interaction. As seen in human leprosy, a stark spatial distribution of CD209 positive macrophage (MF) subsets islinked to the fate of the host and pathogen. We recapitulated divergent CD209 positive MF subsets through primary cell co-culture phenotypic screens, identifying perturbations that licensed the endothelial microenvironment to skew monocytes towards the CD209 positive and CD163 negative MF; subset that is equipped for host defense. Transcriptional profiling of endothelial cells polarized by these structurally diverse activators revealed a subset of mutually regulated genes, and integration with the transcriptome profiles from leprosy lesions led to the discovery that jagged1 (JAG1) expression strongly correlates with the spatial distribution of CD209 positive MF; subsets at the site of disease. These findings suggest that soluble JAG1 may facilitate antimycobacterial human innate immune responses