Linear Polarization Features in the Quiet-Sun Photosphere: Structure and Dynamics

We present detailed characteristics of linear polarization features (LPFs) in the quiet-Sun photosphere from high resolution observations obtained with Sunrise/IMaX. We explore differently treated data with various noise levels in linear polarization signals, from which structure and dynamics of the LPFs are studied. Physical properties of the detected LPFs are also obtained from the results of Stokes inversions. The number of LPFs, as well as their sizes and polarization signals, are found to be strongly dependent on the noise level, and on the spatial resolution. While the linear polarization with signal-to-noise ratio $\geq4.5$ covers about 26% of the entire area in the least noisy data in our study (with a noise level of $1.7\times10^{-4}$ in the unit of Stokes $I$ continuum), the detected (spatially resolved) LPFs cover about 10% of the area at any given time, with an occurrence rate on the order of $8\times10^{-3}$ s$^{-1}$ arcsec$^{-2}$. The LPFs were found to be short lived (in the range of $30-300$ s), relatively small structures (radii of $\approx0.1-1.5$ arcsec), highly inclined, posing hG fields, and move with an average horizontal speed of 1.2 km s$^{-1}$. The LPFs were observed (almost) equally on both upflow and downflow regions, with intensity contrast always larger than that of the the average quiet-Sun.Comment: 20 pages, 9 figures, Accepted for publication in the Solar Physics journa

Lyophilised Biopolymer-Clay Hydrogels for Drug Delivery

Clays have previously demonstrated potential as drug delivery carriers for the extended release of a variety of drugs. The objective of this study was to develop and characterise drug-containing clays in combination with natural hydrogels for the preparation of lyophilised xerogels. Sulfathiazole (STH) (a hydrophobic model drug) was intercalated within the interlayer spaces of Laponite® RDS (LAP RDS) or refined montmorillonite (MMT) and then mixed with either carageenen 812 (CAR 812) or hydrohydroxy ethyl cellulose (HEC) hydrogels prior to lyophilisation. The resulting xerogels were characterised visually, using differential scanning calorimetry (DSC) and with scanning electron microscopy (SEM). Optimal geo-polymeric wafers contained 1.5% W/W CAR 812 with 2% LAP RDSand 1% W/W intercalated STH. DSC and SEM results indicated the amorphous form of STH was intercalated inLAP RDS within theleafy structure of CAR 812. This xerogel hydrated up to1700% within 40 minutes and released the STH by Higuchikinetic model. Keywords: Polymer; Clay, Intercalation, Xerogel, Wound delivery, Amorphous, Physicochemical characterisation, Polymers, hydrogel, drug delivery, lyophilised wafer

Ciprofloxacin-loaded calcium alginate wafers prepared by freeze-drying technique for potential healing of chronic diabetic foot ulcers

Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i.e., porosity, in vitro swelling index, water absorption (Aw), equilibrium water content (EWC), water vapor transmission rate (WVTR), evaporative water loss (EWL), moisture content, in vitro drug release and kinetics, antimicrobial activity, and cell viability (MTT assay) were investigated. The wafers were soft, of uniform texture and thickness, and pliable in nature. Wafers showed ideal wound dressing characteristics in terms of fluid handling properties due to high porosity (SEM). XRD confirmed crystalline nature of the dressings and FTIR showed hydrogen bond formation between CA and CIP. The dressings showed initial fast release followed by sustained drug release which can inhibit and prevent re-infection caused by both Gram-positive and Gram-negative bacteria. The dressings also showed biocompatibility (> 85% cell viability over 72 h) with human adult keratinocytes. Therefore, it will be a potential medicated dressing for patients with DFUs infected with drug-resistant bacteria

Conceptualizing and measuring strategy implementation – a multi-dimensional view

Through quantitative methodological approaches for studying the strategic management and planning process, analysis of data from 208 senior managers involved in strategy processes within ten UK industrial sectors provides evidence on the measurement properties of a multi-dimensional instrument that assesses ten dimensions of strategy implementation. Using exploratory factor analysis, results indicate the sub-constructs (the ten dimensions) are uni-dimensional factors with acceptable reliability and validity; whilst using three additional measures, and correlation and hierarchical regression analysis, the nomological validity for the multi-dimensional strategy implementation construct was established. Relative importance of ten strategy implementation dimensions (activities) for practicing managers is highlighted, with the mutually and combinative effects drawing conclusion that senior management involvement leads the way among the ten key identified activities vital for successful strategy implementation

Development of stable polymeric lyophilised wafers for mucosal drug delivery using thermal annealing (DSC, freeze-drying)

Purpose: The aim was to develop an optimum freeze-drying cycle incorporating annealing to produce wafers from gels comprising κ-carrageenan, poloxamer 407 and PEG 600 with ibuprofen as a model drug. The effects of the annealing process and ibuprofen concentration on water content and mechanical properties of the wafers were also investigated