fac-[N,N′-Bis(3-chloro-2-fluoro­benzyl­idene)ethyl­enediamine]bromido­tri­carbonyl­rhenium(I)

In the title compound, [ReBr(C16H12Cl2F2N2)(CO)3], the Re atom is in a slightly distorted octa­hedral coordination environment with the three carbonyl ligands having a fac configuration. The diimine ligand is equatorial and is bonded to the Re centre in an N,N′-bidentate chelating fashion, with a bite angle of 77.7 (2)°. The dihedral angle between the two benzene rings is 88.7 (6)°. In the crystal structure, there are F⋯O [2.856 (9) Å], Cl⋯C [3.150 (8) Å] and O⋯C [2.984 (10) Å] contacts which are shorter than the sum of the van der Waals radii for these atoms. In addition, symmetry-related mol­ecules are linked via inter­molecular C—H⋯O, C—H⋯Br and the F⋯O inter­actions into one-dimensional chains extending along the a axis. The crystal structure is further stabilized by inter­molecular π–π inter­actions [centroid–centroid distance = 3.571 (5) Å]

Does group prenatal care improve pregnancy outcomes?

It may decrease preterm births, especially among higher-risk women--minority women, women of low socioeconomic status, and adolescents (strength of recommendation [SOR]: B, 1 randomized, controlled trial [RCT] and 1 matched cohort study)

CHARACTERISATION OF STRUCTURAL PLASTICITY OF THE VISUAL CORTEX IN PRMT8 NULL MICE?

Ph.DDOCTOR OF PHILOSOPH

Masters to Doctorate: Impact of the Transition on One Occupational Therapy Program

Within the field of occupational therapy, the issue of transitioning from an entry-level master\u27s degree to an entry-level doctorate degree is under debate. As such, it is important to investigate the impact of the transition in order to help make educated decisions about the potential future of the profession.This study analyzed retrospective data collected from six cohorts at one Midwestern university to analyze the impact of the transition to an entry-level doctorate on diversity, admission and matriculation rates, and fieldwork reservations. No statistical difference in diversity between masters and doctorate level cohorts was found but it is of note that it approached significance (χ2 (1) = 3.32, p = 0.07). There was a slight decrease in number of total students that applied to the program (7.75%) and the number of fieldwork reservations (5.23%), however this was accounted for by a 60% increase in occupational therapy programs in the state the study took place. Results of this study provide preliminary data of how one university has succeeded in the transition to an entry-level doctorate and can be used to inform other programs as they consider this transition

Pregnant women as an effective target for preventive periodontal intervention

Gingivitis and periodontitis are periodontal diseases common to all populations. Gingivitis is a non-specific infection by plaque bacteria while periodontitis is a group of diseases resulting from the interplay of different host responses to specific groups of plaque bacteria

Transcriptional and Chemical Changes in Soybean Leaves in Response to Long-Term Aphid Colonization

Soybean aphids (Aphis glycines Matsumura) are specialized insects that feed on soybean (Glycine max) phloem sap. Transcriptome analyses have shown that resistant soybean plants mount a fast response that limits aphid feeding and population growth. Conversely, defense responses in susceptible plants are slower and it is hypothesized that aphids block effective defenses in the compatible interaction. Unlike other pests, aphids can colonize plants for long periods of time; yet the effect on the plant transcriptome after long-term aphid feeding has not been analyzed for any plant–aphid interaction. We analyzed the susceptible and resistant (Rag1) transcriptome response to aphid feeding in soybean plants colonized by aphids (biotype 1) for 21 days. We found a reduced resistant response and a low level of aphid growth on Rag1 plants, while susceptible plants showed a strong response consistent with pattern-triggered immunity. GO-term analyses identified chitin regulation as one of the most overrepresented classes of genes, suggesting that chitin could be one of the hemipteran-associated molecular pattern that triggers this defense response. Transcriptome analyses also indicated the phenylpropanoid pathway, specifically isoflavonoid biosynthesis, was induced in susceptible plants in response to long-term aphid feeding. Metabolite analyses corroborated this finding. Aphid-treated susceptible plants accumulated daidzein, formononetin, and genistein, although glyceollins were present at low levels in these plants. Choice experiments indicated that daidzein may have a deterrent effect on aphid feeding. Mass spectrometry imaging showed these isoflavones accumulate likely in the mesophyll cells or epidermis and are absent from the vasculature, suggesting that isoflavones are part of a non-phloem defense response that can reduce aphid feeding. While it is likely that aphid can initially block defense responses in compatible interactions, it appears that susceptible soybean plants can eventually mount an effective defense in response to long-term soybean aphid colonization

(3E,5E)-3,5-Dibenzyl­idene-1-[3-(piperidin-1-yl)propano­yl]piperidin-4-one

The asymmetric unit of the title compound, C27H30N2O2, comprises two independent mol­ecules. The dihedral angles between the phenyl rings in the two mol­ecules are 55.59 (8) and 55.39 (8)°. The piperidine rings adopt chair conformations. The crystal structure is stabilized by weak inter­molecular C—H⋯O and C—H⋯N hydrogen bonds. The crystal studied was a non-merohedral twin with a domian ratio of 0.75 (2):0.25 (2)

Stray Flux Monitoring for Reliable Detection of Rotor Faults under the Influence of Rotor Axial Air Ducts

International audienc

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.

Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to migrate out of the blood vessels. Here we show using flow cytometry that sLex expression on basophils and mast cell progenitors depends on fucosyltransferase 6 (FUT6). Using genetic association data analysis and qPCR, the cell type-specific defect was associated with single nucleotide polymorphisms (SNPs) in the FUT6 gene region (tagged by rs17855739 and rs778798), affecting coding sequence and/or expression level of the mRNA. Heterozygous individuals with one functional FUT6 gene harbor a mixed population of sLex+ and sLex- basophils, a phenomenon caused by random monoallelic expression (RME). Microfluidic assay demonstrated FUT6-deficient basophils rolling on E-selectin is severely impaired. FUT6 null alleles carriers exhibit elevated blood basophil counts and a reduced itch sensitivity against insect bites. FUT6-deficiency thus dampens the basophil-mediated allergic response in the periphery, evident also in lower IgE titers and reduced eosinophil counts