Ideal operators and relative Godun sets

In this paper we study ideals in Banach spaces through ideal operators. We provide characterisation of recently introduced notion of almost isometric ideal which is a version of Principle of Local Reexivity for a subspace of a Banach space. Studying ideals through ideal operators give us better insight in to the properties of these subspaces vis-a-vis properties of the space itself. We provide a few applications of our characterisation theorem.The National Board for Higher Mathematics (NBHM) of India. (No.2/40(2)/2014/R&D-II/6252).peerReviewe

Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than electrical current, optical CIs (oCIs) provide more spectral information promising a fundamental improvement of hearing restoration by cochlear implants. Here, we turned to computer modelling for predicting the outcome of optogenetic hearing restoration by future oCIs in humans. We combined three-dimensional reconstruction of the human cochlea with ray-tracing simulation of emission from LED or laser-coupled waveguide emitters of the oCI. Irradiance was read out at the somata of SGNs. The irradiance values reached with waveguides were about 14 times higher than with LEDs, at the same radiant flux of the emitter. Moreover, waveguides outperformed LEDs regarding spectral selectivity. oCIs with either emitter type showed greater spectral selectivity when compared to eCI. In addition, modeling the effects of the source-to-SGN distance, orientation of the sources and impact of scar tissue further informs the development of optogenetic hearing restoration

Global Services Sourcing: Issues of Cost and Quality

Global Services Sourcing (GSS) is not an original concept. What is original about it is the media attention it seems to be getting. We have adopted the “then and now” philosophy in developing this report. We start by talking to the pioneers of global services sourcing, companies like General Electric, Nortel Networks and Citibank. The key learning from talking to these companies who have been sourcing their processes for more than a decade is that the long held view - “went for cost, stayed for quality” about moving processes outside the company (in some cases outside the country) is too simplistic. Rather we found that “went for cost and quality, stayed for continued quality at competitive costs” is more in line with the strategy that that these companies employed. Next, our in depth questionnaire tries to capture the “now” of the global services sourcing industry. Since the pioneers had shone the arc light on quality we developed specific quality related questions. The results validated the pioneers’ views: 67% of the respondents said that actual cost savings from services sourcing have been anywhere from 5% - 50% (onshore and/or offshored). 82% of the respondents said that going into the global services sourcing arrangement they look for quality of processes to increase by 2 – 10% (onshore and/or offshored). 70% of the respondents said that the quality of outsourced business processes has increased (quality increase of 5% -10%) or increased significantly (quality increase of 10% - 25%). The top three drivers of outsourcing were: cost savings, increasing capacity, ability to take advantage of offshore labor (through captive centers). The most difficult phase of outsourcing was transition or handoff of business processes from the company to its outsourcing partner. The top risk factors in outsourcing were: loss of institutional knowledge, poor communication with vendor, mismatch of firm cultures. Of the companies that are engaged in services sourcing, 79% of respondents were using an offshore based provider. Perhaps in a sign of maturing of global services sourcing 62% chose to offshore their services to at least one country in addition to India, the current offshoring destination of choice. As far as country risk factors, legal risks (laws comparable to international standards - data security, intellectual property rights) followed by political risks were identified as the top areas of concern. The lesson for countries competing for offshored business and FDI inflows in services is that the robustness and fairness of the legal system is a major factor for companies especially in the face of concerns about loss of institutional knowledge. The overall satisfaction level with outsourcing was high at 68% but a sizeable chunk of respondents – 26% were either unsatisfied or very unsatisfied with their outsourcing arrangements. Almost all of these unsatisfied firms have been outsourcing for 12 months or less, reinforcing the literature about thinking of outsourcing being a long term investment rather than a short term win

Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction

Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse model of DMD. Utrophin is subject to miRNA mediated repression by several miRNAs including let-7c. Inhibition of utrophin: let-7c interaction is predicted to 'repress the repression' and increase utrophin expression. We developed and tested the ability of an oligonucleotide, composed of 2'-O-methyl modified bases on a phosphorothioate backbone, to anneal to the utrophin 3'UTR and prevent let-7c miRNA binding, thereby upregulating utrophin expression and improving the dystrophic phenotype in vivo. Suppression of utrophin: let-7c interaction using bi-weekly intraperitoneal injections of let7 site blocking oligonucleotides (SBOs) for 1 month in the mdx mouse model for DMD, led to increased utrophin expression along with improved muscle histology, decreased fibrosis and increased specific force. The functional improvement of dystrophic muscle achieved using let7-SBOs suggests a novel utrophin upregulation-based therapeutic strategy for DMD