Correlation of invalidation with symptom severity and health status in fibromyalgia

Objective. Invalidation is a new construct in health psychology, especially in diseases with inherently invisible symptoms such as FM. It can potentially affect both the quality of life and disease severity in patients with FM. This study aimed to investigate the correlation of illness invalidation with health status and symptom severity in FM. Methods. A total of 112 consecutive patients with FM referred to the rheumatology clinic were enrolled. Invalidation was measured by the Illness Invalidation Inventory (3*I). To measure patient status and progress of FM, the Revised Fibromyalgia Impact Questionnaire (FIQR) was used and patients' quality of life was assessed by the 12-item Short Form Health Survey (SF-12). Multiple linear regression analyses were performed and Spearman's correlations were calculated. Results. All the patients were female and aged between 18 and 61 years. No significant differences in discounting and lack of understanding between various sources of invalidation were found. The strongest correlation was observed between FIQR symptom score and discounting by work (r = 0.519, P < 0.05). Multiple linear regression analyses revealed that only discounting from the spouse significantly predicted FIQR total scores of FM patients P = 0.03 (CI 0.28, 10.64). Conclusion. Discounting correlated more strongly with SF-12 subscales and FIQR domains than did lack of understanding. The current study revealed that active negative social responses and the source of invalidation are important in predicting symptom severity and quality of life in FM. © The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved

Geothermal heat flux reveals the Iceland hotspot track underneath Greenland

Curie depths beneath Greenland are revealed by spectral analysis of data from the World Digital Magnetic Anomaly Map 2. A thermal model of the lithosphere then provides a corresponding geothermal heat flux map. This new map exhibits significantly higher frequency but lower amplitude variation than earlier heat flux maps, and provides an important boundary condition for numerical ice‐sheet models and interpretation of borehole temperature profiles. In addition, it reveals new geologically significant features. Notably, we identify a prominent quasi‐linear elevated geothermal heat flux anomaly running northwest‐southeast across Greenland. We interpret this feature to be the relic of the passage of the Iceland hotspot from 80 to 50 Ma. The expected partial melting of the lithosphere and magmatic underplating or intrusion into the lower crust is compatible with models of observed satellite gravity data and recent seismic observations. Our geological interpretation has potentially significant implications for the geodynamic evolution of Greenland