Effect of shir-e-khesht (billinaster drop) consumption by the neonates or their mothers on the neonatal icter

زمینه و هدف: زردی یکی از مشکلات شایع دوران نوزادی است که برای درمان آن از نور درمانی، دارو درمانی، تعویض خون و یا طب سنتی استفاده می کنند. در طب سنتی ایران از ماده ای به نام شیر خشت، (استخراج شده از گیاهان جنس Cotoneaster) جهت درمان زردی نوزادی استفاده می گردد. هدف این تحقیق تعیین تاثیر مصرف شیر خشت (قطره بیلی ناستر) توسط نوزاد یا مادر در بهبودی زردی نوزادان تحت فتوتراپی بود. روش بررسی: در این مطالعه کارآزمایی بالینی 120 نوزاد مبتلا به زردی مراجعه کننده به بخش اطفال بیمارستان هاجر شهرکرد بر اساس روش در دسترس انتخاب و به ترتیب مراجعه در 4 گروه قرار داده شدند. در گروه اول مادر شیر خشت، در گروه دوم مادر و نوزاد هر دو شیرخشت، در گروه سوم نوزاد شیرخشت و درگروه چهارم نوزاد فقط پلاسبو (آب مقطر) دریافت کرد. فتوتراپی در شرایط یکسان برای تمام نوزادان انجام شد. آزمایشات لازم جهت رد نمودن عامل پاتولوژیک زردی انجام گرفت. داده ها به کمک آزمون های آماری کای دو، آنالیز واریانس مشاهدات تکرار شده، آنالیز واریانس، دانت و کروسکال والیس بین گروه ها مقایسه شد. یافته ها: میــزان بیلی روبین طی مطالعه در هر 4 گروه کاهش معنی داری داشت (05/0

Markov Chain Selection Hyper-heuristic for the Optimisation of Constrained Magic Squares

UKCI 2015: UK Workshop on Computational Intelligence, University of Exeter, UK, 7-9 September 2015A square matrix of size n × n, containing each of the numbers (1, . . . , n2) in which every row, column and both diagonals has the same total is referred to as a magic square. The problem can be formulated as an optimisation problem where the task is to minimise the deviation from the magic square constraints and is tackled here by using hyper-heuristics. Hyper-heuristics have recently attracted the attention of the artificial intelligence, operations research, engineering and computer science communities where the aim is to design and develop high level strategies as general solvers which are applicable to a range of different problem domains. There are two main types of hyper-heuristics in the literature: methodologies to select and to generate heuristics and both types of approaches search the space of heuristics rather than solutions. In this study, we describe a Markov chain selection hyper-heuristic as an effective solution methodology for optimising constrained magic squares. The empirical results show that the proposed hyper-heuristic is able to outperform the current state-of-the-art method

Thermal Activation of Dry Sliding Friction at The Nano-scale

Molecular dynamic (MD) simulations are applied to investigate the dependency of the kinetic friction coefficient on the temperature at the nano-scale. The system is comprised of an aluminum spherical particle consisting of 32000 atoms in an FCC lattice sliding on a stack of several layers of graphene, and the simulations have done using LAMMPS. The interaction potential is charge-optimized many-body (COMB3) potential and a Langevin thermostat keep the system at a nearly constant temperature. With an assumption of linear viscous friction, $F_{fr}= - \gamma v$, the kinetic friction coefficient $\gamma$ is derived and plotted at different temperatures in the interval of $T \in [1, 600] K$. As a result, by increasing temperature, the kinetic friction coefficient is decreased. Consequently, while the friction is assumed as a linear viscous model, the results are similar to the thermal activation in atomic-scale friction. That is, (1) by increasing sliding velocity friction force will be increased and (2) by increasing temperature, kinetic friction coefficient decreases.Comment: 7 pages, 5 figure

Effect of silymarin in the prevention of Cisplatin nephrotoxicity, a clinical trial study.

BACKGROUND Reno-protective effect of Silymarin was studied in some studies mainly on rats. In some of these studies, Silymarin was shown to have positive effects on preventing or decreasing severity of Cisplatin nephrotoxicity. OBJECTIVE The aim of this study was to evaluate the protective effect of Silymarin on Cisplatin nephrotoxicity in adult patients with malignancy. MATERIALS AND METHODS In this clinical trial study, 60 patients with malignancy, candidate of Cisplatin treatment were randomly enrolled in two equal groups. In patients of case group, Silymarin tablet 140 mg/bid was administrated seven days before Cisplatin administration together with Cisplatin, and in control group, Cisplatin was prescribed. Blood Urea Nitrogen (BUN) and serum Creatinine (Cr) were checked at the same day and 3 and 7 days after administration of Cisplatin. RESULTS Mean age of the patients in case and control groups were 51.1±14.3 y and 51.1±13.7 y respectively (p=0.99). There was no significant difference based on BUN and serum Cr in the beginning of study and three days after administration of Cisplatin in two groups of patients; however, after two weeks, BUN and serum Cr were significantly lower in the case group compared to the control group. Also, in the case group, BUN and serum Cr decreased and in the control group, they increased after two weeks after Cisplatin administration. CONCLUSION This study showed that Silymarin can decrease Cisplatin nephrotoxicity, so because of safety profile and minor adverse effect of Silymarin, we can use it as prophylaxis against Cisplatin nephrotoxicity in various Cisplatin-contained chemotherapy regimens

The effect of zinc sulphate syrup on children's respiratory tract infections

BACKGROUND AND OBJECTIVE: After Iron, zinc is the second most abundant trace element in the body that is present in all organs, tissues and body fluids. It is a necessary component for maintaining immunological integrity antioxidant activity, and has critical role in the control and prevention of infection. The aim of this study was to investigate the effect of zinc sulphate syrup in treatment of children with respiratory tract infection. METHODS: In this randomized clinical trial study, one hundred and twenty four children with respiratory infection (62 in case and 62 in control group) from pediatric ward of Hajar hospital of Sharekord university enrolled. Both groups received standard treatment. In addition to, zinc sulphate syrup was given to case group and placebo to control group. Respiratory rate, bed and cough and fever duration were compared between the case and control groups (IRCT: 201103025951N1). FINDINGS: The mean duration of fever in the case group was 2.6±0.82 days and in the control group 4±1.5 days (p<0.001). The mean of bed duration in the case group was 4.7±1.5 days and in the control group 5±1.8 days (p=0.42). The mean of cough duration in the case and control groups was 3.4±1.3 and 4.7±1.6 days respectively (p=0.09). Respiratory rate in the case group was 28.3±4.3 and in the control 28.1±4.9 (p=0.77). CONCLUSION: The study showed that zinc supplementation has a beneficial effect in decreasing the fever duration in children with respiratory infection. But there was no significant effect on respiratory rate, duration of bed and cough

Knowledge, attitude and practice about breast cancer screening and related factors among women referred to health care centers in Boroujen in 2005

زمینه و هدف: سرطان پستان شایع ترین سرطان در زنان است. به طوری 16 کل سرطان ها را در ایران به خود اختصاص می دهد و در ایالات متحده آمریکا چهارمین علت مرگ زنان به شمار می آید. از آنجایی که روش های غربالگری از جمله بهترین روش های تشخیص زودرس سرطان پستان می باشند که انجام آنها به طور چشمگیری از شیوع سرطان پیشگیری می کند، لذا این مطالعه به منظور بررسی آگاهی، نگرش و عملکرد زنان مراجعه کننده به مراکز بهداشتی درمانی شهر بروجن نسبت به روشهای غربالگری سرطان پستان انجام گردید. روش بررسی: در یک مطالعه توصیفی - تحلیلی تعداد 400 زن بالای 20 سال از طریق نمونه گیری آسان انتخاب شدند. اطلاعات با استفاده از یک پرسشنامه که شامل مشخصات دموگرافیک و سؤالات آگاهی، نگرش و عملکرد بود جمع آوری گردید. این اطلاعات توسط آزمون های رگرسیون لوجستیک و آزمون کای دو مورد تجزیه و تحلیل قرارگرفت. یافته ها: نتایج نشان داد 8/37 افراد از خودآزمائی، 8/7 از معاینه فیزیکی و 6 افراد از ماموگرافی آگاهی داشتند. نگرش کلی در مورد روشهای غربالگری 6/15 منفی 7/67 در حد متوسط و 7/16 مثبت بود. 1/47 افراد به انجام خودآزمائی، 2/71 به معاینه فیزیکی و 9/68 به انجام ماموگرافی تمایل داشتند. 5/4 افراد خودآزمائی را بطور مرتب و ماهیانه انجام می دادند. در 3/16 افراد معاینه فیزیکی توسط پزشک و کارکنان بهداشتی انجام شده بود که فقط 4 به منظور غربالگری صورت گرفته بود. 3/4 افراد ماموگرافی غربالگری انجام داده بودند. مهمترین عامل مؤثر بر خودآزمائی، سابقه وجود بیماری خوش خیم پستان در فرد بود (05/0

Comparison of N-acetylcysteine, ascorbic acid, and normal saline effect in prevention of contrast-induced nephropathy

BACKGROUND: Considering the crucial role of appropriate preventative strategies in reducing the rate of contrast-induced nephropathy (CIN) occurrence and its related morbidity and mortality, the effect of N-acetylcysteine (NAC), ascorbic acid (AA), and normal saline (NS) was investigated in the patient's undergone coronary angiography. METHODS: In this clinical trial, 120 patients scheduled for elective coronary angiography with serum creatinine (Cr) level > 1.5 mg/dl or glomerular filtration rate (GFR) >= 60 selected by convenience method. Selected patients were allocated in three treatment groups randomly to receive oral NAC (600 mg/twice daily) plus NS (100 ml/hour) (Group A), oral AA (250 mg/twice daily) plus NS (100 ml/hour) (Group B) and NS (100 ml/hour) (Group C), respectively. The occurrence of CIN was evaluated based on serum Cr and GFR in three studied groups, before and after angiography procedure. The analysis of variance and paired t-test were used for data analysis by SPSS. RESULTS: The serum Cr increased and GFR decreased significantly during the intervention in three groups (P 0.050). CONCLUSION: The study showed that nor the addition of NAC neither the addition of AA to sodium chloride infusion has more beneficial effect than hydration with sodium chloride, in the prevention of CIN

The effect of teaching using, problem base learning and lecture on behavior, attitude and learning of nursing (BSc) students

Background and aim: Problem base learning results in the clarification of the words and concepts, the definition of the concepts, problem analysis, providing a systematic method to describe the situation during analysis process, the determination of learning objectives, getting more knowledge according to learning requirements and merging of the new knowledge with solutions. Regarding the progress of nursing science across the world and the importance of promotion in nursing education using new educational methods, the aim of this research was to determine the effect of teaching using both problem base learning and lecture on behavior, attitude and learning of nursing (BSc) students at Shahre-Kord university of medical science. Methods: This research was a semi-experimental study involved 40 of nursing (at 4th semester) students at Shahre-Kord university of medical sciences who were learning the internal course (surgery 2). They were selected using conventional sampling method and divided into two equal groups of case and control, using random sampling method. The problem base learning and lecture methods were used to teach individuals of case and control groups, respectively. At the end of the course, using a questionnaire, behavior, attitude, and learning of the students were assessed. Using T and Manvitni tests, the data was analyzed. Results: The students were 95% female and single. The mean of age in both groups was 22/04±1 years. There was no significant difference between the two groups in terms of the three former semester average scores, using t-test. The mean of learning in the case and control was 68.24±6.8 and 44.98±9.8, respectively. The mean of attitude in the case and control was 123.3±21 and 96.8±8 and the mean of behavior in the two groups was 69.5±2.5 and 63±3.1, respectively (p<0.001). There was significant statistical difference (p<0.05) in the two categories of evaluation and application between the two groups studied (p<0.05). There was also slight difference in the level of understanding between these two groups. Conclusion: Based on the results, teaching by problem base learning is more useful than lecture in modification and improvement of learning and attitude of the students studied. The results of this research is offered and recommended to the educational officials to substitute this method for the traditional ones

A hybrid ANN-GA model to prediction of bivariate binary responses: Application to joint prediction of occurrence of heart block and death in patients with myocardial infarction

Background: In medical studies, when the joint prediction about occurrence of two events should be anticipated, a statistical bivariate model is used. Due to the limitations of usual statistical models, other methods such as Artificial Neural Network (ANN) and hybrid models could be used. In this paper, we propose a hybrid Artificial Neural Network-Genetic Algorithm (ANN-GA) model to prediction the occurrence of heart block and death in myocardial infarction (MI) patients simultaneously. Methods: For fitting and comparing the models, 263 new patients with definite diagnosis of MI hospitalized in Cardiology Ward of Hajar Hospital, Shahrekord, Iran, from March, 2014 to March, 2016 were enrolled. Occurrence of heart block and death were employed as bivariate binary outcomes. Bivariate Logistic Regression (BLR), ANN and hybrid ANN-GA models were fitted to data. Prediction accuracy was used to compare the models. The codes were written in Matlab 2013a and Zelig package in R3.2.2. Results: The prediction accuracy of BLR, ANN and hybrid ANN-GA models was obtained 77.7%, 83.69% and 93.85% for the training and 78.48%, 84.81% and 96.2% for the test data, respectively. In both training and test data set, hybrid ANN-GA model had better accuracy. Conclusions: ANN model could be a suitable alternative for modeling and predicting bivariate binary responses when the presuppositions of statistical models are not met in actual data. In addition, using optimization methods, such as hybrid ANN-GA model, could improve precision of ANN model. © 2016, Health Hamadan University of Medical Sciences. All rights reserved