Antiviral activity of organic molecules having sulfonamide moiety: An insight of recent research

Sulfonamide derivatives are well known for their antibacterial activity as manifested by ‘Sulfa Drugs’, for example, sulfamethoxazole etc. In addition, they are associated with a large number of pharmacological activities such as anti-microbial, anti-inflammatory, anti-cancer, anti-oxidant, anti-viral etc. This work has emphasized their application as antiviral agents such as HIV (human immunodeficiency virus), HCV (hepatitis C virus) etc. We have presented here a number of sulfonamide derivatives exhibiting remarkable antiviral potential

Genetic diversity studies in common bean (Phaseolus vulgaris L.) using molecular markers

Molecular characterization of thirteen common bean genotypes was done with random amplified polymorphic DNA (RAPD) markers. Initially, 15 primers were screened out of which only seven were selected which generated a total of 65 amplification products out of which 63 bands (96.62%) were polymorphic indicating fair amount of polymorphism. The genotypes shared 43% genetic similarity among themselves. Cluster analysis delineated the genotypes into three groups with seven, five and one genotype in cluster-I, II and III, respectively. The maximum similarity index (82.35) based dice similarity coefficient was obtained between SKUA-R-21 and SKUA-R-19, while it was minimum (27.72) between genotypes PBG-29 and SKUA-R-01.Key words: Genetic divergence, common bean, random amplified polymorphic DNA (RAPD)

Reform Movements In India And Sri Lanka: A Comparative Study

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Are Topological Charge Fluctuations in QCD Instanton Dominated?

We consider a recent proposal by Horv\'ath {\em et al.} to address the question whether topological charge fluctuations in QCD are instanton dominated via the response of fermions using lattice fermions with exact chiral symmetry, the overlap fermions. Considering several volumes and lattice spacings we find strong evidence for chirality of a finite density of low-lying eigenvectors of the overlap-Dirac operator in the regions where these modes are peaked. This result suggests instanton dominance of topological charge fluctuations in quenched QCD.Comment: LaTeX, 15 pages, 8 postscript figures, minor improvements, version to appear in PR

Measurement of hybrid content of heavy quarkonia using lattice NRQCD

Using lowest-order lattice NRQCD to create heavy meson propagators and applying the spin-dependent interaction, $c_B^{} \frac{-g}{2m_q}\vec\sigma\cdot\vec{B}$, at varying intermediate time slices, we compute the off-diagonal matrix element of the Hamiltonian for the quarkonium-hybrid two-state system. Thus far, we have results for one set of quenched lattices with an interpolation in quark mass to match the bottomonium spectrum. After diagonalization of the two-state Hamiltonian, we find the ground state of the $\Upsilon$ to show a $0.0035(1)c_B^2$ (with $c_B^2 \sim 1.5-3.1$) probability admixture of hybrid, $|b\bar{b}g>$.Comment: 11 pages, 4 figures, to appear in Phys Rev

Passively Q-switched fiber lasers using a multi-walled carbon nanotube polymer composite based saturable absorber

We demonstrate a simple, compact and low cost Q-switched fiber lasers based on Erbium-doped fiber (EDF) and Thulium-doped fiber (TDF) to operate at 1534.5 nm and 1846.4 nm, respectively by exploiting a multi-walled carbon nanotubes (MWCNTs) polymer composite film based saturable absorber (SA). The composite is prepared by mixing the MWCNTs homogeneous solution into a dilute polyvinyl alcohol polymer solution before it is left to dry at room temperature to produce thin film. Then the film is sandwiched between two FC/PC fiber connectors and integrated into the laser cavity for Q-switching pulse generation. The EDF laser generates a stable pulse train with repetition rates ranging from 38.11 kHz to 48.22 kHz by varying the 980 nm pump power from 39.0 mW to 65.3 mW. At the 65.3 mW pump power, the pulse width and pulse energy were 5.3 μs and 99.75 nJ, respectively. The TDF laser generates a stable pulse train with 10.38 kHz repetition rate, 17.52 μs pulse width and 11.34 nJ pulse energy at 121.1 mW 800 nm pump power. A higher performance Q switching is expected to be achieved in both fiber lasers with the optimization of the SA and laser cavity

Numerical study of O(a) improved Wilson quark action on anisotropic lattice

The $O(a)$ improved Wilson quark action on the anisotropic lattice is investigated. We carry out numerical simulations in the quenched approximation at three values of lattice spacing ($a_{\sigma}^{-1}=1$--2 GeV) with the anisotropy $\xi=a_{\sigma}/a_{\tau}=4$, where $a_{\sigma}$ and $a_{\tau}$ are the spatial and the temporal lattice spacings, respectively. The bare anisotropy $\gamma_F$ in the quark field action is numerically tuned by the dispersion relation of mesons so that the renormalized fermionic anisotropy coincides with that of gauge field. This calibration of bare anisotropy is performed to the level of 1 % statistical accuracy in the quark mass region below the charm quark mass. The systematic uncertainty in the calibration is estimated by comparing the results from different types of dispersion relations, which results in 3 % on our coarsest lattice and tends to vanish in the continuum limit. In the chiral limit, there is an additional systematic uncertainty of 1 % from the chiral extrapolation. Taking the central value $\gamma_F=\gamma_F^*$ from the result of the calibration, we compute the light hadron spectrum. Our hadron spectrum is consistent with the result by UKQCD Collaboration on the isotropic lattice. We also study the response of the hadron spectrum to the change of anisotropic parameter, $\gamma_F \to \gamma_F^* + \delta\gamma_F$. We find that the change of $\gamma_F$ by 2 % induces a change of 1 % in the spectrum for physical quark masses. Thus the systematic uncertainty on the anisotropic lattice, as well as the statistical one, is under control.Comment: 27 pages, 25 eps figures, LaTe

A lattice NRQCD calculation of the B0−Bˉ0B^0-\bar{B}^0 mixing parameter B_B

We present a lattice calculation of the B meson B-parameter B_B using the NRQCD action. The heavy quark mass dependence is explicitly studied over a mass range between m_b and 4m_b with the $O(1/m_Q)$ and $O(1/m_Q^2)$ actions. We find that the ratios of lattice matrix elements $/^2$ and $/^2$, which contribute to B_B through mixing, have significant $1/m_Q$ dependence while that of the leading operator $/^2$ has little $1/m_Q$ effect. The combined result for B_B(m_b) has small but non-zero mass dependence, and the B_B(m_b) becomes smaller by 10% with the 1/m_Q correction compared to the static result. Our result in the quenched approximation at \beta=5.9 is B_{B_d}(5 GeV) = 0.75(3)(12), where the first error is statistical and the second is a systematic uncertainty.Comment: 20 pages, 11 figures, uses REVTeX, typos correcte

Scaling of the B and D meson spectrum in lattice QCD

We give results for the $B$ and the $D$ meson spectrum using NRQCD on the lattice in the quenched approximation. The masses of radially and orbitally excited states are calculated as well as $S$-wave hyperfine and $P$-wave fine structure. Radially excited $P$-states are observed for the first time. Radial and orbital excitation energies match well to experiment, as does the strange-non-strange $S$-wave splitting. We compare the light and heavy quark mass dependence of various splittings to experiment. Our $B$-results cover a range in lattice spacings of more than a factor of two. Our $D$-results are from a single lattice spacing and we compare them to numbers in the literature from finer lattices using other methods. We see no significant dependence of physical results on the lattice spacing. PACS: 11.15.Ha 12.38.Gc 14.40.Lb 14.40.NdComment: 78 pages, 29 tables, 30 figures Revised version. Minor corrections to spelling and wordin

Charmonium Spectrum from Quenched Anisotropic Lattice QCD

We present a detailed study of the charmonium spectrum using anisotropic lattice QCD. We first derive a tree-level improved clover quark action on the anisotropic lattice for arbitrary quark mass. The heavy quark mass dependences of the improvement coefficients, i.e. the ratio of the hopping parameters $\zeta=K_t/K_s$ and the clover coefficients $c_{s,t}$, are examined at the tree level. We then compute the charmonium spectrum in the quenched approximation employing $\xi = a_s/a_t = 3$ anisotropic lattices. Simulations are made with the standard anisotropic gauge action and the anisotropic clover quark action at four lattice spacings in the range $a_s$=0.07-0.2 fm. The clover coefficients $c_{s,t}$ are estimated from tree-level tadpole improvement. On the other hand, for the ratio of the hopping parameters $\zeta$, we adopt both the tree-level tadpole-improved value and a non-perturbative one. We calculate the spectrum of S- and P-states and their excitations. The results largely depend on the scale input even in the continuum limit, showing a quenching effect. When the lattice spacing is determined from the $1P-1S$ splitting, the deviation from the experimental value is estimated to be $\sim$30% for the S-state hyperfine splitting and $\sim$20% for the P-state fine structure. Our results are consistent with previous results at $\xi = 2$ obtained by Chen when the lattice spacing is determined from the Sommer scale $r_0$. We also address the problem with the hyperfine splitting that different choices of the clover coefficients lead to disagreeing results in the continuum limit.Comment: 43 pages, 49 eps figures, revtex; minor changes, version to appear in Physical Review