Synthesis, characterization and urease inhibitory activities of Zn(II) complexes bearing C1-symmetric ligands derived from (R)-phenylethanamine

ABSTRACT. A series of Zn(II) complexes, supported with N-substituted phenylethanamine derivatives, [LnZnCl2] (where Ln = LA ((R)-1-phenyl-N-(thiophene-2-ylmethyl)ethanamine; LB (R)-N-(5-meyhylthiophene-2-yl)methyl-1-phenylethanamine; LC ((R)-N-(furan-2-ylmeththyl)-1-phenylethanamine and LD (R)-N-((5-methylfuran-2-yl)methyl)-1-phenylethanamine) were synthesized and characterized. The urease inhibitory activities of these complexes were determined against selected urease inhibitors where [LBZnCl2] was found to be the most prominent inhibitor of Jack bean urease (J. B. urease) (IC50 = 10.39±0.78 μM), whereas the activity of Bacillus pasteurii urease (B. P. urease) was predominantly inhibited by [LAZnCl2] (IC50 = 8.68±0.7 μM). Additionally, MOE-Dock program was used to affirm the probable binding modes of these complexes into the crystal structure of J. B. urease which certainly verified the inhibitory mechanism of these novel complexes.                     KEY WORDS: Zn(II) complexes, (R)-Phenylethanamine, Urease inhibition, Molecular docking   Bull. Chem. Soc. Ethiop. 2021, 35(2), 301-314. DOI: https://dx.doi.org/10.4314/bcse.v35i2.

Callus induction via different growth regulators from cotyledon explants of indigenous chick pea (Cicer arietinum L.) cultivars KK-1 and Hassan-2K

Callus induction from cotyledon explants was studied in indigenous chick pea (Cicer arietinum L.) cultivars KK-1 and Hassan-2K on MS and B5 media containing different combinations and concentrations of growth regulators. Different MS and B5 callusing media containing varying level of 2, 4-D (2 and 4 mg/l), NAA (0.50 and 1 mg/l), BAP (5 and 10 μM) and their combinations were tested for callus induction response. Percent callus and callus fresh weight (g) were recorded after two and four weeks of culture for both genotypes. For KK-1 cultivar, the maximum callus frequency (71 and 97%) followed by (65 and 96%) were observed on 4 mg/l 2,4-D+5 μM BAP in MS and 4 mg/l 2,4-D in B5 media, respectively after two and four weeks of culture. Similarly, the highest callus fresh weight (0.411 and 0.787 g) were also recorded for MS+4 mg/l 2,4-D+5 μM BAP in contrast to B5 where the highest callus weight (0.401 and 0.693 g) was achieved on 4 mg/l 2,4-D only. In Hassan -2K, the highest callus % (68 and 96) and fresh weight (0.572 and 0.821 g) were recorded on MS+4 mg/l 2,4-D+0.50 mg/l NAA after two and four weeks of culture, respectively. In B5 medium, 2,4-D+BAP combination produced average callus induction response for both cultivars.Key words: Callus induction, chick pea cotyledons, growth regulators

Phyto-agglutinin, total proteins and amino assimilating enzymatic activity of indigeneous chickpea (Cicer arietinum L.) cultivars

Biochemical studies were carried out with in vitro micropropagated plantlets of two indigenous cultivars of chickpea (Cicer arietinum L.), KK-1 and Hassan-2K, where extract from shoots, leaves, roots, and reproductive organs were determined for human erythrocyte agglutination (by mixing the lectin containing extract 1:1 with a 2% erythrocyte suspension), protein profiling and the amino assimilating (glutamine synthetase) enzymatic activity. Both of KK-1 and Hassan-2K cultivars extract showed highly phyto-agglutination of human erythrocytes with reproductive organs and other tissues, which represents the presence of potent lectins (phyto-agglutinin). The amino assimilating enzymatic activity of green leaves of Hasan-2K was found higher (3.545 GS μmol.gfw-1.min-1) as compared to KK-1 (2.873 GS μmol.gfw-1.min-1). Protein content profile showed variation in bulk proteins of various tissues, higher (12.634 μg/gfw) and (2.987 μg/gfw) in reproductive organs of KK-1 and Hasan-2K, respectively.Key words: Chickpea, glutamine synthetase, glyco-protein, lectin, phyto-agglutinin

Anthropic tuning of the weak scale and of m_u/m_d in two-Higgs-doublet models

It is shown that in a model in which up-type and down-type fermions acquire mass from different Higgs doublets, the anthropic tuning of the Higgs mass parameters can explain the fact that the observed masses of the $d$ and $u$ quarks are nearly the same with $d$ slightly heavier. If Yukawa couplings are assumed not to "scan" (vary among domains), this would also help explain why the t quark is much heavier than the b quark. It is also pointed out that the existence of dark matter invalidates some earlier anthropic arguments against the viability of domains where the Standard Model Higgs has positive $\mu^2$, but makes other even stronger arguments possible.Comment: 31 pages, 7 figure

Vasopressin for the management of catecholamine-resistant anaphylactic shock

Severe anaesthetic anaphylaxis is relatively uncommon. Oxygen, fluids and epinephrine are considered to be the mainstay for treatment of cardiovascular collapse and current guidelines for the management of anaphylaxis list only epinephrine as a vasopressor to use in the event of a cardiovascular collapse. Recently, evidence has emerged in the support of the use of vasopressin in cardiopulmonary resuscitation, it is also recommended for the treatment of ventricular fibrillation, septic shock and post-cardiopulmonary bypass distribution shock. Currently, there is no algorithm or guideline for the management of anaphylaxis that include the use of vasopressin. We report a 24-year-old woman who developed severe anaphylactic shock at induction of anaesthesia while undergoing laparoscopic cholecystectomy. Circulation shock was refractory to epinephrine and high doses of pure alpha-agonist phenylephrine and norepinephrine. Single intravenous dose of two units of vasopressin re-established normal circulation and blood pressure

Search for a Signal on QCD Critical Point in Central Nucleus-Nucleus Collisions

We discuss that the QCD critical point could appear in central collisions in percolation cluster. We suggest using the nuclear transparency effect and the one of the light nuclear production to identify the critical point.Comment: To appear in the proceedings of the 20th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions (QM2008), Jaipur, India, February 4-10, 200

Regular ag-groupoids characterized by (∈, ∈ ∨ q k)-fuzzy ideals

In this paper, we introduce a considerable machinery which permits us to characterize a number of special (fuzzy) subsets in AG -groupoids. Generalizing the concepts of (∈, ∈ ∨q) -fuzzy bi-ideals (interior ideal), we define (∈, ∈ ∨ q k) -fuzzy bi-ideals, (∈, ∈ ∨ q k )-fuzzy left (right)-ideals and ( , ) k ? ? ?q -fuzzy interior ideals in AG -groupoids and discuss some fundamental aspects of these ideals in AG -groupoids. We further define ( ∈, ∈ ∨ q k) -fuzzy bi-ideals and (∈, ∈ ∨ q k)-fuzzy interior ideals and give some of their basic properties in AG -groupoids. In the last section, we define lower/upper parts of (∈, ∈ ∨ q k ) -fuzzy left (resp. right) ideals and investigate some characterizations of regular and intera-regular AG -groupoids in terms of the lower parts of ( ∈, ∈ ∨ q k ) -fuzzy left (resp. right) ideals and ( ∈, ∈ ∨ q k )-fuzzy bi-ideal of AG -groupoids