Giant Parotid Tumor

Malignant parotid tumors are uncommon tumors. Although pleomorphic adenoma is the commonest benign tumor of the parotid accounting for 65% of tumors but malignant tumors are also seen frequently in parotid gland. Normally these tumors are slow growing with a long history of lump in the parotid gland. The rapid growth phase in these tumors indicate malignant transformation. The involvement of facial nerve is a late symptom and denote advance stage. We are presenting a giant malignant tumor of the parotid gland measuring 22cm x 15cm in a lady of 50 years. To the best of our knowledge this is the biggest tumor reported so far in Pakistan

Challenges Faced by the Repatriates and their Subsequent Impact on Repatriates’ Satisfaction

Objective: Through decades repatriation has been the most ignored and a problematic phase of the Expatriate Management Cycle (EMC). Expatriates when returning back to their home country are referred as Repatriates and this returning phase is known as Repatriation phase of the Expatriate Management Cycle. This Repatriation phase is mainly the unplanned stage where organizational managers make the mistake. They certainly believe that the repatriates are returning back to their home and wrongly assumes that there will be no complications or challenges for these repatriates on their arrival back to home country. This strategic lack results in the immense dissatisfaction of these repatriates soon after arrival to the home county. Our aim is to provide a detailed study on the process of repatriation by identifying the challenges that are faced by the repatriates on their arrival to the home country and to oversee their subsequent impact on their job performance. Methodology: Data was collected through primary means using convenience sampling method through various organizations and of 300 respondents 186 were filtered out to be analyzed using different statistical techniques on SPSS. Result: There exist a significant negative relationship between all the identified challenges faced by the repatriates and their job satisfaction level Implication: At the end of the research some recommendations were also proposed for the organizational managers to overcome these challenges. This piece of research can not only be used by the researchers for their research work but can also be based by the organizational managers to formulate their repatriation strategies

Supramolecular homobimetallic bis-diorganotin(IV) complexes of ditopic oxygen nitrogen donor ligand:Synthesis, spectroscopic characterization, crystal structure and biological screening

Six new homobimetallic bis-diorganotin(IV) complexes: [Me2Sn](2)L (1), [Et2Sn](2)L (2), [n-Bu2Sn](2)L (3), [Ph2Sn](2)L (4), [Oct(2)Sn](2)L (5) and [n-BuClSn](2)L (6) (H (4) L=N-1', N-6'-bis(2-hydroxybenzylidene)adipodihydrazide) have been synthesized and structurally characterized by means of elemental analysis, mass spectroscopy, FT-IR, NMR (H-1, C-13{H-1}, Sn-119) and single-crystal X-ray diffraction. Spectroscopic studies indicate coordination of the ligand to the diorganotin(IV) moieties via iminolic oxygen, nitrogen and phenolic oxygen atoms generating pentacoordinated tin centers. Single-crystal X-ray analysis of (1) revealed homobimetallic nature of complex with dimethyltin moieties oriented in trans-conformation. The ligand is non-planar with each Sn atom in a distorted square pyramidal coordination geometry. Packing diagrams suggest the essential role of C-(HN)-N-aEuro broken vertical bar and C-(HO)-O-aEuro broken vertical bar interactions in generating supramolecular assembly. The ligand and complexes were screened for in vitro antimicrobial activity and cytotoxicity. Compound (4) exhibits highest cytotoxicity

The Pharm.D. in Pakistan: A Curricular Innovation in Health Systems Instruction

The Pharm.D. in Pakistan: A Curricular Innovation in Health Systems Instructio

An Empirical Examination of E-Government Virtual Services: Mediating Role of Users’ Perceived Usefulness

Government websites are the repository of information where citizens can timely access substantial and reliable information. It is normal to find antagonism between formulators and users of e-government virtual services (EGS). This study is designed to assess the quality of virtual services provided by Pakistani government websites. Data is collected from 278 university graduates using simple random sampling technique. Results of Smart PLS show that the survey respondents exhibit positive attitude towards perceived system quality (PSQ) and perceived information quality (PIQ) of the websites. They also perceive e-government websites useful and display their satisfaction to e-government virtual services. Finally, findings provide support to mediating role of users’ perceived usefulness (UPU). Policymakers and practitioners can take advantage of the findings to design more citizen centered government websites to optimize their satisfaction with mandatory services

Effect of visible range electromagnetic radiations on Escherichia coli

Background: Escherichia coli is the agent responsible for a range of clinical diseases. With emerging antimicrobial resistance, other treatment options including solar/photo-therapy are becoming increasingly common. Visible Range Radiation Therapy/Colour Therapy is an emerging technique in the field of energy/vibrational medicine that uses visible spectrum of Electromagnetic Radiations to cure different diseases. In this study, our goal was to understand the effect of Visible Range Electromagnetic Radiations on E. coli (in vitro) and therefore find out the most appropriate visible range radiation for the treatment of diseases caused by E. coli.Materials and Methods: A total of 6 non-repetitive E. coli isolates were obtained from urine samples obtained from hospitalized patients with UTI. Single colony of E. coli was inoculated in 3 ml of Lysogeny Broth (LB) and 40 μl of this E. coli suspension was poured into each of the plastic tubes which were then irradiated with six different wavelengths in the visible region (Table. 1) after 18 hours with one acting as a control. The Optical Densities of these irradiated samples were then measured. Furthermore, scanning electron microscopy (TEFCAN ZEGA3) was carried out.Results: The analysis of the microscopic and SEM images of irradiated E. coli samples with six different visible range radiations is representative of The fact that E. coli responded differently to every applied radiation in the visible region and the most profound inhibitory effects were that of 538nm Visible Range Radiation (Green) which proved to be bactericidal and 590nm Visible Range Radiation (yellow) which was bacteriostatic. The enhanced growth of E. coli with varying degrees was clearly observed in 610nm (orange), 644nm (red), 464nm (Purple) and 453nm (blue).Conclusion: It can be concluded that 538nm (Green) and 590nm (Yellow) can effectively be used for treating E. coli borne diseases.Keywords: Visible Range Radiation Therapy, E. coli, UTI, Alternative Treatment, Colour Therap

Dieth­yl[N-(3-meth­oxy-2-oxidobenzyl­idene)-N′-(oxidomethyl­ene)hydrazine-κ3 O,N,O′]tin(IV)

In the mol­ecule of the title compound, [Sn(C2H5)2(C9H8N2O3)], the Sn atom is five-coordinated in a distorted trigonal-bipyramidal configuration by two O and one N atoms of the tridentate Schiff base ligand in the equatorial plane, and by two C atoms of ethyl groups in the axial positions. In the crystal structure, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers

(2,2′-Bipyridine-κ2 N,N′){[(3-meth­oxy-2-oxidobenzyl­idene-κO 2)hydrazono]methano­lato-κ2 N 2,O}dimethyl­tin(IV)

In the crystal structure of the title compound, [Sn(CH3)2(C9H8N2O3)(C10H8N2)], the Sn atom exhibits a penta­gonal bipyramidal coordination geometry defined by two C, three N and two O atoms. The bond distances for Sn—C, Sn—N and Sn—O are in the ranges 2.097 (3)–2.098 (3), 2.298 (2)–2.623 (2) and 2.157 (2)–2.266 (2) Å, respectively. The mol­ecular structure of the monomeric compound is stabilized by three intra­molecular C—H⋯O hydrogen bonds, all involving bipyridine C—H groups

EFFECT OF VISIBLE RANGE ELECTROMAGNETIC RADIATIONS ON ESCHERICHIA COLI

Background: Escherichia coli is the agent responsible for a range of clinical diseases. With emerging antimicrobial resistance, other treatment options including solar/photo-therapy are becoming increasingly common. Visible Range Radiation Therapy/Colour Therapy is an emerging technique in the field of energy/vibrational medicine that uses visible spectrum of Electromagnetic Radiations to cure different diseases. In this study, our goal was to understand the effect of Visible Range Electromagnetic Radiations on E. coli (in vitro) and therefore find out the most appropriate visible range radiation for the treatment of diseases caused by E. coli. Materials and Methods: A total of 6 non-repetitive E. coli isolates were obtained from urine samples obtained from hospitalized patients with UTI. Single colony of E. coli was inoculated in 3 ml of Lysogeny Broth (LB) and 40 μl of this E. coli suspension was poured into each of the plastic tubes which were then irradiated with six different wavelengths in the visible region (Table. 1) after 18 hours with one acting as a control. The Optical Densities of these irradiated samples were then measured. Furthermore, scanning electron microscopy (TEFCAN ZEGA3) was carried out. Results: The analysis of the microscopic and SEM images of irradiated E. coli samples with six different visible range radiations is representative of The fact that E. coli responded differently to every applied radiation in the visible region and the most profound inhibitory effects were that of 538nm Visible Range Radiation (Green) which proved to be bactericidal and 590nm Visible Range Radiation (yellow) which was bacteriostatic. The enhanced growth of E. coli with varying degrees was clearly observed in 610nm (orange), 644nm (red), 464nm (Purple) and 453nm (blue). Conclusion: It can be concluded that 538nm (Green) and 590nm (Yellow) can effectively be used for treating E. coli borne diseases

Assessment of Growth Inhibition of Eugenol-Loaded Nano-Emulsions against Beneficial Bifidobacterium sp. along with Resistant Escherichia coli Using Flow Cytometry

The intestinal tract microbiota influences many aspects of the dietary components on colon health and during enteric infections, thus, playing a pivotal role in the colon health. Therefore, the eugenol (EU) nano-emulsion effective concentration reported in our previous study against cancer cells should be explored for safety against beneficial microbes. We evaluated the sensitivity of Bifidobacterium breve and B. adolescentis against EU-loaded nano-emulsions at 0, 300, 600 and 900 µm, which were effective against colon and liver cancer cells. Both B. breve and B. adolescentis showed comparable growth ranges to the control group at 300 and 600 µm, as evident from the plate count experimental results. However, at 900 µm, a slight growth variation was revealed with respect to the control group. The real-time inhibition determination through flow cytometry showed B. breve viable, sublethal cells (99.49 and 0.51%) and B. adolescentis (95.59 and 0.15%) at 900 µm, suggesting slight inhibition even at the highest tested concentration. Flow cytometry proved to be a suitable quantitative approach that has revealed separate live, dead, and susceptible cells upon treatment with EU nano-emulsion against Escherichia coli. Similarly, in the case of B. breve and B. adolescentis, the cells showed only live cells that qualitatively suggest EU nano-emulsion safety. To judge the viability of these sublethal populations of B. breve and B. adolescentis, Fourier transforms infrared spectroscopy was carried out, revealing no peak shift for proteins, lipids, DNA and carbohydrates at 900 µm EU nano-emulsion compared to the control. On the other hand, EU-loaded nano-emulsions (900 µm)-treated E. coli showed a clear peak shift for a membrane protein, lipids, DNA and carbohydrates. This study provides insights to utilize plant phenols as safe medicines as well as dietary supplements