Development of Nickel Catalyzed Cross-Coupling Methodologies

In this work, we have addressed some of the issues surrounding catalytic crosscoupling reactions by using a nickel terpyridine catalyst, [Ni(tpy)(py)(CH3CN)2](PF6)2 in the Buchwald-Hartwig amination reaction and a functionalized variant, [(2,2\u27:6\u27,2\u27\u27- terpyridine-4\u27-benzoic acid)Ni(II)]Cl2 on SiO2, in Suzuki coupling. These processes are unique in the approaches taken to achieve reactivity. In the Buchwald-Hartwig amination reaction, we used photoredox dual catalytic methods to achieve a sustainable approach to generate secondary and tertiary amines. This report is unique in many ways; most importantly, this method uses N-centered radicals to generate new C-N bonds. This report is also the first report to show generation of secondary and tertiary amines in the same reaction scaffold. For the Suzuki reaction, we developed a heterogeneous nickel catalyst by immobilization of a nickel terpyridine analogue on a solid oxide support. By doing so, we created a recyclable catalyst that can operate up to five reactions before suffering deactivation. The approach is more effective than homogeneous reactions, as the catalyst is easily reclaimed and simplifies both purification and analysis. We further developed this process by immobilizing the molecular catalyst using Atomic Layer Deposition. This approach allows for a physical barrier to be added to the catalyst motif that increases practical stability. Indeed, the immobilization worked effectively, allowing more than six reactions without any catalyst deactivation in aqueous solvents. After immobilization, activity was observed towards heteroaryl substrates, a useful moiety in pharmaceutical drug targets

Successful use of Onyx® for transcatheter arterial embolization of a scrotal arteriovenous malformation refractory to traditional embolic agents

AbstractA scrotal arteriovenous malformation (AVM) is a rare condition representing an abnormal connection between the arterial and venous systems of vessels supplying the scrotum. Scrotal AVMs are usually treated via transcatheter embolization, surgical extirpation, or a combination of the two approaches. A 41-year-old man developed a life-threatening hemorrhage from a scrotal AVM. After hemodynamic stability was attained, multiple transcatheter embolization procedures were performed (over the course of several months) to eliminate blood flow through the AVM. Traditional embolic agents including microcoils, Embospheres®, and Gelfoam® were used, with only temporary reduction of blood flow through the AVM. Onyx®, a liquid embolic agent, was used successfully as an adjunct treatment to achieve blood flow cessation. Onyx® demonstrates efficacy in the treatment of scrotal AVMs, and is a viable alternative to traditional embolic agents

Concert recording 2016-04-23c

[Track 01]. Unfamiliar territory. Local spirits ; [Track 02]. As night falls ; [Track 03]. Shortcuts / Michael Markowski -- [Track 04]. Phantastes / James Greeson -- [Track 05]. Escapades. Closing in ; [Track 06]. Reflections ; [Track 07]. Joyride / John Williams -- [Track 08]. Sultana / John Mackey

Concert recording 2014-02-11

[Track 01]. Alto sax sonata. Moderate-lively-moderate ; [Track 02]. Slow waltz ; [Track 03]. Quick fast / Robert Baksa -- [Track 04]. Allemande from Partita in A minor / J.S. Bach -- [Track 05]. Sonatina / William Schmidt

Concert recording 2016-02-28

[Track 01]. Bagatellen. Elegie ; [Track 02]. Scherzo ; [Track 03]. Aria ; [Track 04]. Gigue / Erwin Dressel -- [Track 05]. Sonata. Allegro, ma non troppo ; [Track 06]. Sarabande ; Allegro / Wolfgang Jacobi -- [Track 07]. Flirtations. Sweet nothings ; [Track 08]. These soft shoes ; [Track 09]. Showtune / Michael Markowski -- [Track 10]. Sonata. Allegro ; [Track 11]. Andantino cantabile ; [Track 12]. Allegro vivace / Lawson Lunde

Concert recording 2015-11-22a

[Track 01]. Saxophone quartet. Elegie ; [Track 02]. Finale / Paul Reade -- [Track 03]. Gallumphery from Diversions in denim / Carl Anton Wirth -- [Track 04]. Shepherd\u27s hey / Percy Grainger -- [Track 05]. He is good and handsome / Pierre Passereau -- [Track 06]. Chorale prelude and fugue / J.S. Bach ; arranged by Laycock -- [Track 07]. Fugue in D / Michael Hanna -- [Track 08]. Explorations / Ryan Key -- [Track 09]. Fugato in F / René Borel -- [Track 10]. Finale from Quartett, opus 109 / Alexander Glazunov

Concert recording 2014-04-06

[Track 01]. Rigaudon de Dardanus / Jean-Philippe Rameau ; arranged by Corroyez -- [Track 02]. What shall we do with a drunken sailor? / Sea Chantey ; arranged by Worley -- [Track 03]. Quartette / Caryl Florio -- [Track 04]. Diversions in denim. Excursion ; [Track 05]. Idlewood ; [Track 06]. Gallumphery ; [Track 07]. Lornsome ; [Track 08]. Shindig / Carl Anton Wirth -- [Track 09]. Finale from Brandenburg concerto no. 3 / J.S. Bach ; arranged by Laycock -- [Track 10]. Portals / Carl Anton Wirth -- [Track 11]. Moderato ; [Track 12]. Allegro / Erland von Koch

Assessing simulation ecosystem processes for climate variability research at Glacier National Park

Glacier National Park served as a test site for ecosystem analyses that involved a suite of integrated models embedded within a geographic information system. The goal of the exercise was to provide managers with maps that could illustrate probable shifts in vegetation, net primary production (NPP), and hydrologic responses associated with two selected climatic scenarios. The climatic scenarios were (a) a recent 12-yr record of weather data, and (b) a reconstituted set that sequentially introduced in repeated 3-yr intervals wetter–cooler, drier–warmer, and typical conditions. To extrapolate the implications of changes in ecosystem processes and resulting growth and distribution of vegetation and snowpack, the model incorporated geographic data. With underlying digital elevation maps, soil depth and texture, extrapolated climate, and current information on vegetation types and satellite-derived estimates of leaf area indices, simulations were extended to envision how the park might look after 120 yr. The predictions of change included underlying processes affecting the availability of water and nitrogen. Considerable field data were acquired to compare with model predictions under current climatic conditions. In general, the integrated landscape models of ecosystem processes had good agreement with measured NPP, snowpack, and streamflow, but the exercise revealed the difficulty and necessity of averaging point measurements across landscapes to achieve comparable results with modeled values. Under the extremely variable climate scenario significant changes in vegetation composition and growth as well as hydrologic responses were predicted across the park. In particular, a general rise in both the upper and lower limits of treeline was predicted. These shifts would probably occur along with a variety of disturbances (fire, insect, and disease outbreaks) as predictions of physiological stress (water, nutrients, light) altered competitive relations and hydrologic responses. The use of integrated landscape models applied in this exercise should provide managers with insights into the underlying processes important in maintaining community structure, and at the same time, locate where changes on the landscape are most likely to occur

Concert recording 2016-04-17

[Track 01]. Ballade no. 2 in F major op. 38 / Frédéric Chopin -- [Track 02]. Sonata. Allegro moderato / Bruce Broughton -- [Track 03]. La catedral / Augustin Barrios-Mangoré -- [Track 04]. Largo al factotum from Il barbiere di Siviglia / Gioachino Rossini -- [Track 05]. First sonata for flute and piano. Allegro moderato / Bohuslav Martinu -- [Track 06]. The odyssey, according to Penelope. Afternoon in the park ; Toddling waltz / Kevin Bobo -- [Track 07]. Flirtations : 3 songs for solo alto saxophone / Michael Markowski -- [Track 08]. Depuis le jour from Louise / Gustave Charpentier -- [Track 09]. New Orleans / Eugene Bozza

Concert recording 2013-11-16b

[Track 01]. Brushstrokes on a simple field / Jeff Payne ; edited by Jacob Lee -- [Track 02]. Song among hills ; [Track 03]. Mythos unbound ; [Track 04]. Sketches on an autumn day / Jeff Payne