A Knowledge Matrix Modeling of the Intelligence Cycle

This effort models information flow through the United States Intelligence Community\u27s Intelligence Cycle using a knowledge matrix methodology. The knowledge matrix methodology takes explicit data from multiple sources and fuses that data to measure a current level of knowledge about a target, or situation. Knowledge matrices are used to develop a measure of user-needs satisfaction. User-needs satisfaction compares requested levels of knowledge to a probability of collecting that knowledge within a designated timeframe. This effort expands the work done by Captain Carl Pawling in his March 2004 thesis, Modeling and Simulation of the Military Intelligence Process, by modeling intelligence as an opportunistic, multi-source, multi-entity system of systems. The value of intelligence fusion is compared, and analyzed between three different algorithms; no fusion, a mixed forward and fuse strategy, and strict fusion strategy. These fusion algorithms are then applied to competing intelligence collection architectures in varying intelligence activity scenarios to determine which architectures will most improve the probability of satisfactory collection. Satisfactory collection is measured in terms of quantity, timeliness, and user-need satisfaction of completed intelligence reports

Stroboscopic Generation of Topological Protection

Trapped neutral atoms offer a powerful route to robust simulation of complex quantum systems. We present here a stroboscopic scheme for realization of a Hamiltonian with $n$-body interactions on a set of neutral atoms trapped in an addressable optical lattice, using only 1- and 2-body physical operations together with a dissipative mechanism that allows thermalization to finite temperature or cooling to the ground state. We demonstrate this scheme with application to the toric code Hamiltonian, ground states of which can be used to robustly store quantum information when coupled to a low temperature reservoir.Comment: 5 pages, 2 figures. Published versio

Quantum non-demolition measurements of single donor spins in semiconductors

We propose a technique for measuring the state of a single donor electron spin using a field-effect transistor induced two-dimensional electron gas and electrically detected magnetic resonance techniques. The scheme is facilitated by hyperfine coupling to the donor nucleus. We analyze the potential sensitivity and outline experimental requirements. Our measurement provides a single-shot, projective, and quantum non-demolition measurement of an electron-encoded qubit state.Comment: 8+ pages. 4 figures. Published versio

Qubits as spectrometers of dephasing noise

We present a procedure for direct characterization of the dephasing noise acting on a single qubit by making repeated measurements of the qubit coherence under suitably chosen sequences of controls. We show that this allows a numerical reconstruction of the short time noise correlation function and that it can be combined with a series of measurements under free evolution to allow a characterization of the noise correlation function over many orders of magnitude range in timescale. We also make an analysis of the robustness and reliability of the estimated correlation functions. Application to a simple model of two uncorrelated noise fluctuators using decoupling pulse sequences shows that the approach provides a useful route for experimental characterization of dephasing noise and its statistical properties in a variety of condensed phase and atomic systems.Comment: 10 pages, 3 figure

The Ursinus Weekly, February 27, 1975

Women\u27s open dorms suspended for Friday P.M. • Forum: Savitch reports • Festival of Arts includes music, crafts and dance • Union creates Hell\u27s Half Acre • 1975 interview schedule • Bloodmobile will visit U.C. campus • Football team donates gift to Varsity Club • Focus: Dean Ruth R. Harris; George P. Kinek • Editorial: Time for all or time for none • Can the Flyers repeat? • Overtime jinx • Yes we can in 1975 • Badminton: Good • Hoopla • U.C. grapplers end seasonhttps://digitalcommons.ursinus.edu/weekly/1030/thumbnail.jp

Optically active gossypol as a circular dichroism probe of interactions with serum albumins

The (+)-enantiomer of the polyphenolic binaphthyl gossypol, has been shown to be a useful CD probe of interactions with human and bovine serum albumin. (+)-Gossypol binds to albumin with same affinity as recemic (±)-gossypol, as shown by fluorescence quenching, and also displaces bilirubin from its albumin binding site. The CD characteristics of bound gossypol are different in the case of the two proteins

Investigation into the Heat of Hydration and Alkali Silica Reactivity of Sustainable Ultrahigh Strength Concrete with Foundry Sand

This study presents the hydration reactivity and alkali silica reaction (ASR) of ultrahigh strength concrete (UHSC) that has been made more sustainable by using spent foundry sand. Spent foundry sand not only is sustainable but has supplementary cementitious material (SCM) characteristics. Two series of UHSC mixtures were prepared using a nonreactive and reactive sand (in terms of ASR) to investigate both the impact of a more reactive aggregate and the use of spent foundry sand. Conduction calorimetry was used to monitor the heat of hydration maintained under isothermal conditions, while ASR was investigated using the accelerated mortar bar test (AMBT). Additionally, the compressive strengths were measured for both series of mixtures at 7, 14, and 28 days to confirm high strength requirements. The compressive strengths ranged from 85 MPa (12,345 psi) to 181.78 MPa (26,365 psi). This result demonstrates that a UHSC mixture was produced. The calorimetry results revealed a slight acceleration in the heat of hydration flow curve compared to the control from both aggregates indicating increased hydration reactivity from the addition of foundry waste. The combination of foundry sand and reactive sand was found to increase ASR reactivity with increasing additions of foundry sand up to 30% replacement

Rapid High Yield Production of Different Glycoforms of Ebola Virus Monoclonal Antibody

Fc-glycosylation of monoclonal antibodies (mAbs) has profound implications on the Fc-mediated effector functions. Alteration of this glycosylation may affect the efficiency of an antibody. However, difficulties in the production of mAbs with homogeneous N-glycosylation profiles in sufficient amounts hamper investigations of the potential biological impact of different glycan residues.Here we set out to evaluate a transient plant viral based production system for the rapid generation of different glycoforms of a monoclonal antibody. Ebola virus mAb h-13F6 was generated using magnICON expression system in Nicotiana benthamiana, a plant species developed for commercial scale production of therapeutic proteins. h-13F6 was co-expressed with a series of modified mammalian enzymes involved in the processing of complex N-glycans. Using wild type (WT) plants and the glycosylation mutant ΔXTFT that synthesizes human like biantennary N-glycans with terminal N-acetylglucosamine on each branch (GnGn structures) as expression hosts we demonstrate the generation of h-13F6 complex N-glycans with (i) bisected structures, (ii) core α1,6 fucosylation and (iii) β1,4 galactosylated oligosaccharides. In addition we emphasize the significance of precise sub Golgi localization of enzymes for engineering of IgG Fc-glycosylation.The method described here allows the efficient generation of a series of different human-like glycoforms at large homogeneity of virtually any antibody within one week after cDNA delivery to plants. This accelerates follow up functional studies and thus may contribute to study the biological role of N-glycan residues on Fcs and maximizing the clinical efficacy of therapeutic antibodies