Javaserver page, Java servlet and JavaBean technology: Online real estate company

This project will simulate an online real estate company using JSP, Java Servlet and JavaBean technology

Wounds That Will Not Heal Pervasive Cellular Reprogramming in Cancer

There has been an explosion of articles on epithelial-mesenchymal transition and other modes of cellular reprogramming that influence the tumor microenvironment. Many controversies exist and remain to be resolved. The interest of the pathologists in the molecular and functional parallels between wound healing and the developing tumor stroma has its earliest origin in the writings of Rudolph Virchow in the 19th century. Since then, most of the focus has been primarily on the dynamics of the extracellular matrix; however, new interest has been redirected toward deciphering and understanding the enigmatic, yet elegant, plasticity of the cellular components of the proliferating epithelia and stroma and how they are reciprocally influenced. Citing several examples from breast cancer research, we will trace how these perspectives have unfolded in the pages of The American Journal of Pathology and other investigative journals during the past century, their impact, and where the field is headed

‘Uncertainty is the only certainty’ : how pragmatic sociology provides a useful theoretical framework for researching the third sector during COVID-19

This work was supported by The Rank Foundation, charity number: 276976.This research note argues that pragmatic sociology is a useful theoretical framework when researching the third sector during the uncertain times of COVID-19 and beyond. It begins by introducing pragmatic sociology, which describes how actors express their values through the ‘orders of worth’ framework, and then how they justify their practices during moments of conflict, through the process of ‘tests’. This ultimately employs complex and fragile moments in history to uncover meaning making and, by extension, individual and organisational practice. This article then demonstrates useful research questions that pragmatic sociology can offer for the third sector during this uncertain time and how this theory’s utility can be applied even after the pandemic, due to its embracement of organisational dynamism, nuance and a fresh approach to power relationships.PostprintPeer reviewe

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection.

The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). While the KSHV genome is chromatin-free in the virions, the viral DNA in latently infected cells has a chromatin structure with activating and repressive histone modifications that promote latent gene expression but suppress lytic gene expression. Here, we report a comprehensive epigenetic study of the recruitment of chromatin regulatory factors onto the KSHV genome during the pre-latency phase of KSHV infection. This demonstrates that the KSHV genome undergoes a biphasic chromatinization following de novo infection. Initially, a transcriptionally active chromatin (euchromatin), characterized by high levels of the H3K4me3 and acetylated H3K27 (H3K27ac) activating histone marks, was deposited on the viral episome and accompanied by the transient induction of a limited number of lytic genes. Interestingly, temporary expression of the RTA protein facilitated the increase of H3K4me3 and H3K27ac occupancy on the KSHV episome during de novo infection. Between 24-72 hours post-infection, as the levels of these activating histone marks declined on the KSHV genome, the levels of the repressive H3K27me3 and H2AK119ub histone marks increased concomitantly with the decline of lytic gene expression. Importantly, this transition to heterochromatin was dependent on both Polycomb Repressive Complex 1 and 2. In contrast, upon infection of human gingiva-derived epithelial cells, the KSHV genome underwent a transcription-active euchromatinization, resulting in efficient lytic gene expression. Our data demonstrate that the KSHV genome undergoes a temporally-ordered biphasic euchromatin-to-heterochromatin transition in endothelial cells, leading to latent infection, whereas KSHV preferentially adopts a transcriptionally active euchromatin in oral epithelial cells, resulting in lytic gene expression. Our results suggest that the differential epigenetic modification of the KSHV genome in distinct cell types is a potential determining factor for latent infection versus lytic replication of KSHV

The QM evolution: Behavioral quality management as a firm’s strategic resource

Firms implement various quality management (QM) practices to improve process quality. Scholars recognize that QM practices consist of both technical and behavioral oriented practices. The relationship of technical and behavioral oriented practices on performance has led to paradoxical relationships. Improving quality performance necessitates understanding the relationship between technical and behavioral orientated practices. This study empirically examines the relationship between technical and behavioral quality practices by collecting survey data from both US-based (N = 152) and China-based (N = 222) firms. The analysis uses the structural equation modeling technique, and shows that behavioral QM practices fully mediate the relationship between technical QM practices and firm performance. This implies that behavioral QM practices act as a strategic resource which helps generate a competitive advantage. The results contribute to understanding how quality management practices can lead to a competitive advantage

The Human Capital Agenda: Asset Holding and Educational Attainment Among African-American Youth

This study extends previous analyses in several ways. First, in addition to parental wealth, the relationship between children’s wealth and math and reading scores are examined. Second, we examine different mediating pathways that wealth may affect children’s math and reading scores in a single path analysis model. The advantage of path analysis over traditional regression analyses, which are typically used in this area, is that researchers can get a glimpse of relationships among variables. While the focus of regression analysis is on the associations of predictors with outcome variables, path analysis provides a larger picture of the overall structure of relationships among variables in predicting the outcome variable. Furthermore, mediation can be tested more easily and extensively in path analysis compared to regression. Third, we examine whether different forms of wealth (net worth, homeownership, and children’s savings for school) have different effects. Forth, we examine whether wealth (parental and/or children’s) effects vary across racial groups

Fibre-optic metadevice for all-optical signal modulation based on coherent absorption

Recently, coherent control of the optical response of thin films of matter in standing waves has attracted considerable attention, ranging from applications in excitation-selective spectroscopy and nonlinear optics to demonstrations of all-optical image processing. Here we show that integration of metamaterial and optical fibre technologies allows the use of coherently controlled absorption in a fully fiberized and packaged switching metadevice. With this metadevice, that controls light with light in a nanoscale plasmonic metamaterial film on an optical fibre tip, we provide proof-of-principle demonstrations of logical functions XOR, NOT and AND that are performed within a coherent fully fiberized network at wavelengths between 1530 nm and 1565 nm. The metadevice performance has been tested with optical signals equivalent to a bitrate of up to 40 Gbit/s and sub-milliwatt power levels. Since coherent absorption can operate at the single photon level and also with 100 THz bandwidth, we argue that the demonstrated all-optical switch concept has potential applications in coherent and quantum information networks.Comment: 9 pages, 6 figure

Robust nanostructures with exceptionally high electrochemical reaction activity for high temperature fuel cell electrodes

Metal nanoparticles are of significant importance for chemical and electrochemical transformations due to their high surface-to-volume ratio and possible unique catalytic properties. However, the poor thermal stability of nano-sized particles typically limits their use to low temperature conditions (<500 °C). Furthermore, for electrocatalytic applications they must be placed in simultaneous contact with percolating ionic and electronic current transport pathways. These factors have limited the application of nanoscale metal catalysts (diameter <5 nm) in solid oxide fuel cell (SOFC) electrodes. Here we overcome these challenges of thermal stability and microstructural design by stabilizing metal nanoparticles on a scaffold of Sm_(0.2)Ce_(0.8)O_(2−δ) (SDC) films with highly porous and vertically-oriented morphology, where the oxide serves as a support, as a mixed conducting transport layer for fuel electro-oxidation reactions, and as an inherently active partner in catalysis. The SDC films are grown on single crystal YSZ electrolyte substrates by means of pulsed-laser deposition, and the metals (11 μg cm^(−2) of Pt, Ni, Co, or Pd) are subsequently applied by D.C. sputtering. The resulting structures are examined by TEM, SIMS, and electron diffraction, and metal nanoparticles are found to be stabilized on the porous SDC structure even after exposure to 650 °C under humidified H_2 for 100 h. A.C. impedance spectroscopy of the metal-decorated porous SDC films reveals exceptionally high electrochemical reaction activity toward hydrogen electro-oxidation, as well as, in the particular case of Pt, coking resistance when CH_4 is supplied as the fuel. The implications of these results for scalable and high performance thin-film-based SOFCs at reduced operating temperature are discussed