The development and application of a new tool to assess the adequacy of the content and timing of antenatal care

Abstract Background: Current measures of antenatal care use are limited to initiation of care and number of visits. This study aimed to describe the development and application of a tool to assess the adequacy of the content and timing of antenatal care. Methods: The Content and Timing of care in Pregnancy (CTP) tool was developed based on clinical relevance for ongoing antenatal care and recommendations in national and international guidelines. The tool reflects minimal care recommended in every pregnancy, regardless of parity or risk status. CTP measures timing of initiation of care, content of care (number of blood pressure readings, blood tests and ultrasound scans) and whether the interventions were received at an appropriate time. Antenatal care trajectories for 333 pregnant women were then described using a standard tool (the APNCU index), that measures the quantity of care only, and the new CTP tool. Both tools categorise care into 4 categories, from ‘Inadequate’ (both tools) to ‘Adequate plus’ (APNCU) or ‘Appropriate’ (CTP). Participants recorded the timing and content of their antenatal care prospectively using diaries. Analysis included an examination of similarities and differences in categorisation of care episodes between the tools. Results: According to the CTP tool, the care trajectory of 10,2% of the women was classified as inadequate, 8,4% as intermediate, 36% as sufficient and 45,3% as appropriate. The assessment of quality of care differed significantly between the two tools. Seventeen care trajectories classified as ‘Adequate’ or ‘Adequate plus’ by the APNCU were deemed ‘Inadequate’ by the CTP. This suggests that, despite a high number of visits, these women did not receive the minimal recommended content and timing of care. Conclusions: The CTP tool provides a more detailed assessment of the adequacy of antenatal care than the current standard index. However, guidelines for the content of antenatal care vary, and the tool does not at the moment grade over-use of interventions as ‘Inappropriate’. Further work needs to be done to refine the content items prior to larger scale testing of the impact of the new measure

Inadequate prenatal care and its association with adverse pregnancy outcomes: A comparison of indices

<p>Abstract</p> <p>Background</p> <p>The objectives of this study were to determine rates of prenatal care utilization in Winnipeg, Manitoba, Canada from 1991 to 2000; to compare two indices of prenatal care utilization in identifying the proportion of the population receiving inadequate prenatal care; to determine the association between inadequate prenatal care and adverse pregnancy outcomes (preterm birth, low birth weight [LBW], and small-for-gestational age [SGA]), using each of the indices; and, to assess whether or not, and to what extent, gestational age modifies this association.</p> <p>Methods</p> <p>We conducted a population-based study of women having a hospital-based singleton live birth from 1991 to 2000 (N = 80,989). Data sources consisted of a linked mother-baby database and a physician claims file maintained by Manitoba Health. Rates of inadequate prenatal care were calculated using two indices, the R-GINDEX and the APNCU. Logistic regression analysis was used to determine the association between inadequate prenatal care and adverse pregnancy outcomes. Stratified analysis was then used to determine whether the association between inadequate prenatal care and LBW or SGA differed by gestational age.</p> <p>Results</p> <p>Rates of inadequate/no prenatal care ranged from 8.3% using APNCU to 8.9% using R-GINDEX. The association between inadequate prenatal care and preterm birth and LBW varied depending on the index used, with adjusted odds ratios (AOR) ranging from 1.0 to 1.3. In contrast, both indices revealed the same strength of association of inadequate prenatal care with SGA (AOR 1.4). Both indices demonstrated heterogeneity (non-uniformity) across gestational age strata, indicating the presence of effect modification by gestational age.</p> <p>Conclusion</p> <p>Selection of a prenatal care utilization index requires careful consideration of its methodological underpinnings and limitations. The two indices compared in this study revealed different patterns of utilization of prenatal care, and should not be used interchangeably. Use of these indices to study the association between utilization of prenatal care and pregnancy outcomes affected by the duration of pregnancy should be approached cautiously.</p

Qualidade e eqüidade na assistência à gestante: um estudo de base populacional no Sul do Brasil

This population-based study aimed to evaluate prenatal coverage according to family income in a municipality (county) in Southern Brazil. Data were collected using a questionnaire with mothers in the first 24 hours postpartum. Prenatal coverage, first prenatal consultation in the first trimester, six or more consultations, breast and colposcopic examination, routine prenatal laboratory tests according to the protocol of the Program for Humanization of Prenatal and Delivery Care (PHPN), and prenatal ultrasound increased proportionally with family income, and all were more frequent in women from the highest income quartile (p < 0.001). Despite these results, the prevalence of low birth weight did not show a statistically significant difference between the quartiles. The local health service appeared not to be very effective, since only 26.8% of the women were classified as having received adequate prenatal care according to the PHPN criteria, and care was unequal, since quality of care for women in the lowest income quartile was inferior to that of women in the highest quartile.Estudo de base populacional com objetivo de avaliar a cobertura da assistência pré-natal, de acordo com a renda familiar, em município do Sul do Brasil. As informações foram coletadas por questionário, com as mães nas primeiras 24 horas após o parto. Observase que a cobertura pré-natal, o inicio das consultas no primeiro trimestre, a realização de seis consultas ou mais, a execução do exame das mamas e do exame especular, a realização dos exames de laboratório da rotina pré-natal do Programa de Humanização no Pré-natal e Nascimento (PHPN) e a realização da ultra-sonografia, aumentam com a melhoria da renda familiar, sendo mais realizados nas gestantes do quartil de maior renda (p < 0,001). Apesar destes resultados, a prevalência de baixo peso ao nascer não apresentou diferença estatística significante entre os diferentes quartis. O serviço local de saúde mostrou-se pouco efetivo porque apenas 26,8% dos pré-natais foram classificados como adequados, segundo parâmetros do PHPN, e desigual porque as pacientes do menor quartil de renda tiveram o acompanhamento da sua gestação com qualidade inferior à das pacientes do quarto quartil

Data treatment for LC-MS untargeted analysis

Liquid chromatography-mass spectrometry (LC-MS) untargeted experiments require complex chemometrics strategies to extract information from the experimental data. Here we discuss “data preprocessing”, the set of procedures performed on the raw data to produce a data matrix which will be the starting point for the subsequent statistical analysis. Data preprocessing is a crucial step on the path to knowledge extraction, which should be carefully controlled and optimized in order to maximize the output of any untargeted metabolomics investigatio