A Wholistic Model of Apologetics for Equipping the Youth

Problem While available studies indicate that biblical world view among young adults decreases in years of secular education Adventist education system in Germany is struggling to address the needs of the young adults. The question arises what kind of needs can be identified why they leave faith and church behind and how the Church may counteract this process and provide valuable assistance. The urgency of this question emerges in considering the high rate of de-conversion among Adventist youth. Method This study analyzes various studies and statistical reports regarding the condition of the spiritual life of young adults in both the secular and Christian community, focusing especially on their unmet needs. To examine the target group of young German Adventists between 16 and 31 years of age specific data has been conducted by a questionnaire about the apologetic abilities among this group. Results The results of the study show that almost all de-conversions (96%) come about until the age of 35 and that among Adventist youth the de-conversion rate is around 50%. The underlying reasons of de-conversion are categorized in intellectual, emotional and spiritual aspects. Conclusions In a time of multitudes of contradicting world views and concepts, apologetics can be used to strengthen biblical world view among young Adventist adults. A systematic approach of apologetics needs to be comprehensive to meet the needs of young people in secular environments. Such an implementation of apologetics with components of intellect, affection, and spirituality can counteract the process of de-conversion by fostering a solid basis of faith, namely a biblical world view. It presents an effective instrument to educate the youth and can empower young people in well-founded and well-justified faith so they are able to defend their faith for themselves and others

Cerebral Infarction in an Elderly Patient with Coronavirus Disease

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Seed yield and quality of pepper plants grown under salt stress

The effect of salinity on seed yield and quality of pepper plants were evaluated. Plants were grown in five salt levels (electrical conductivity, EC): 1.0, 1.5, 2.0, 4.0 to 6.0 dSm-1 in glasshouse. Seed yield was assessed by seed weight/fruit, seed weight/plant and individual seed weight. Seed quality was measured by germination, mean germination time, seedling growth and germination percentages after cold (10°C, 7 days, 25°C 10 days) accelerated ageing (45°C, 48 h) and high temperature germination (35°C, 14 days) tests. Results indicate that seed yield per fruit greatly reduced from 1990 mg at control to 460 mg at 4 dSm-1 but individual seed weight did not change until 1.5 dSm-1 EC. Seed quality concerning all criteria maintained high up to 2.0 dSm-1 EC while seed germination and vigour were significantly reduced at 4.0 dSm-1 EC. Pepper plants did not yield seeds at 6 dS-1 EC. It can be concluded that pepper seed yield reduced significantly at even very low salinity (1 dSm-1), however, quality began to decline after 2.0 dSm-1 EC.Key words: Pepper, fruit yield, seed quality, salinity

Production and Characterization of Peptide Antibodies to the C-Terminal of Frameshifted Calreticulin Associated with Myeloproliferative Diseases

Myeloproliferative Neoplasms (MPNs) constitute a group of rare blood cancers that are characterized by mutations in bone marrow stem cells leading to the overproduction of erythrocytes, leukocytes, and thrombocytes. Mutations in calreticulin (CRT) genes may initiate MPNs, causing a novel variable polybasic stretch terminating in a common C-terminal sequence in the frameshifted CRT (CRTfs) proteins. Peptide antibodies to the mutated C-terminal are important reagents for research in the molecular mechanisms of MPNs and for the development of new diagnostic assays and therapies. In this study, eight peptide antibodies targeting the C-terminal of CRTfs were produced and characterised by modified enzyme-linked immunosorbent assays using resin-bound peptides. The antibodies reacted to two epitopes: CREACLQGWTE for SSI-HYB 385-01, 385-02, 385-03, 385-04, 385-07, 385-08, and 385-09 and CLQGWT for SSI-HYB 385-06. For the majority of antibodies, the residues Cys1, Trp9, and Glu11 were essential for reactivity. SSI-HYB 385-06, with the highest affinity, recognised recombinant CRTfs produced in yeast and the MARIMO cell line expressing CRTfs when examined in Western immunoblotting. Moreover, SSI-HYB 385-06 occasionally reacted to CRTfs from MPN patients when analysed by flow cytometry. The characterized antibodies may be used to understand the role of CRTfs in the pathogenesis of MPNs and to design and develop new diagnostic assays and therapeutic targets. Keywords: calreticulin; epitope mapping; frameshift mutations; myeloproliferative neoplasms; peptide antibodies

An investigation of the effects of emotion coaching on 4-5 age group children in terms of various dimensions

Araştırmada, öğretmenin uygulamış olduğu duygu koçluğunun okul öncesi dönem çocuklarının duygu düzenleme ve sosyal becerileri ile istenmeyen davranışları üzerine etkilerinin incelenmesi amaçlanmıştır. Araştırma karma yöntem modeline uygun olarak planlanmış ve yürütülmüştür. Araştırmada bulunan deney ve kontrol grupları, amaçlı örneklem yöntemi ile belirlenmiştir. Bu araştırmanın çalışma grubu, 2021-2022 eğitim-öğretim yılında Bursa İli Nilüfer ilçesinde Milli Eğitim Bakanlığı’na bağlı resmi anaokulu bünyesinde eğitime devam eden 15 çocuk deney grubu, 15 çocuk kontrol grubu ve bu öğrencilerin öğretmenlerinden oluşmaktadır. Çalışmanın nicel boyutunda çocukların sosyal beceri düzeylerini belirlemek amacı ile “Sosyal Beceri Geliştirme Sistemi Derecelendirme Ölçeği”, duygu düzenleme beceri düzeylerini belirlemek amacı ile “Okul Öncesi Duygu Düzenleme Ölçeği” kullanılmıştır. Aynı zamanda nitel boyutu için çocukların ve ebeveynlerinin demografik bilgilerine ulaşmak amacı ile araştırmacının hazırlamış olduğu “Kişisel Bilgi Formu”, öğretmenler ile görüşmek adına “Görüşme Formu” ve araştırmacı tarafından sınıf içi süreci gözlemlemek adına “Araştırmacı Gözlem Formu” uygulanmıştır. Verilerin düzenlenmesinde Microsoft Excel 2016 programı, verilerin analizinde Microsoft SPSS 28.0 programı kullanılmıştır. Araştırmadan elde edilen verilerin analizi için, Bağımsız Örneklem t-Testi, Mann-Whitney U, Bağımlı Örneklem t-Testi ve Wilcoxon İşaretli Sıralar Testi kullanılmıştır. Deney ve kontrol grupları ön test puan ortalamaları arasında istatiksel olarak anlamlı bir fark olmadığı ve yapılan ön gözlemler ve ön görüşmeler sonucunda öğretmenlerin sınıf içi uygulamalarının ve davranışlarının da benzer olduğu bulunurken son test puan ortalamaları arasında deney grubu lehine anlamlı farklılık bulunmuştur. Aynı zamanda son görüşmeler sonucunda elde edilen nitel verilerden doğrultusunda öğretmenlerin sınıf içi uygulamalarının ve davranışlarının da farklılaştığı deney grubu öğretmenin kendini alanında daha yetkin hissettiği, sınıf ortamında yaşanan sosyal duygusal sorunların azaldığı ve yaşanan problem durumlarında duygu koçluğu yaklaşımı uygulamasını aktif olarak kullanıldığı sonucuna ulaşılmıştır. Bu sonuçlar doğrultusunda, öğretmenin duygu koçluğu yaklaşımı uygulamasının, çocukların sosyal becerileri ve duygu düzenleme becerilerini geliştirmede etkili olduğu sonucuna varılmakla beraber istenmeyen davranışları azaltmada da olumlu etkisinin olduğu anlaşılmakta ve öğretmen davranışları üzerinde anlamlı ölçüde etkisi olduğu görülmektedir.In the study, it was aimed to examine the effects of emotion coaching applied by the teacher on the emotion regulation and social skills of preschool children and their unwanted behaviors. The research was planned and conducted in accordance with the mixed method model. Experimental and control groups in the study were determined by purposive sampling method. The study group of this research consists of 15 experimental groups, 15 control groups and teachers of these students who continue their education in the official kindergarten affiliated to the Ministry of National Education in Bursa Province Nilüfer district in the 2021-2022 academic year. In the quantitative aspect of the study, the "Social Skills Development System Rating Scale" was used to determine the social skill levels of the children, and the "Preschool Emotion Regulation Scale" was used to determine the emotion regulation skill levels. At the same time, the "Personal Information Form" prepared by the researc her to reachthe demographic information of the children and their parents for the qualitative dimension, the "Interview Form" to meet with the teachers, and the "Researcher Observation Form" to observe the classroom process were applied by the researcher. Microsoft Excel 2016 program was used to organize the data, and Microsoft SPSS 28.0 program was used to analyze the data. Independent Sample t-Test, Mann-Whitney U, Dependent Sample t-Test and Wilcoxon Signed Rank Test were used to analyze the data obtained from the study. While it was found that there was no statistically significant difference between the pre-test mean scores of the experimental and control groups, and as a result of the pre-observations and pre-interviews, the in-class practices and behaviors of the teachers were similar. At the same time, in line with the qualitative data obtained as a result of the last interviews, it was concluded that the classroom practices and behaviors of the teachers differed, the experimental group teacher felt more competent in his field, the social emotional problems experienced in the classroom environment decreased and the application of emotion coaching approach was actively used in the problem situations. In line with these results, it is concluded that the teacher's emotion coaching approach is effective in improving children's social skills and emotion regulation skills, but it also has a positive effect on reducing unwanted behaviors and has a significant effect on teacher behaviors

HİZMET KALİTESİNİN SERVQUAL MODELİ İLE ÖLÇÜLMESİ: AİLE SAĞLIĞI MERKEZLERİ ÜZERİNE BİR ARAŞTIRMA

Sağlık kuruluşlarında hizmetlerin kalitesi, çoğu yönetici için teşhisten tedaviye hizmet sunumunu olanaklı hale getiren teknik unsurların kalitesi anlamına gelmektedir. Ancak hasta bakış açısıyla hizmet kalitesi, sağlık hizmeti sunanların anlayışından farklı olarak, hizmetin teknik yönü kadar, sağlık kuruluşunun fiziksel olanakları, atmosferi, personelin yaklaşımı gibi unsurları kapsamaktadır. Bu çalışmada, Denizli ilindeki on adet aile sağlığı merkezindeki hastalardan 180 kişiden anketteki önermeleri 5'li Likert ölçeğine göre değerlendirmeleri istenmiştir. Elde edilen verilere göre, aile sağlığı merkezinin algılanan ve beklenen hizmet kalitesi düzeyleri ve hizmet kalitesi boyutlarının servqual skorları hesaplanmıştır. Servqual skorları; fiziksel özellikler, güvenilirlik, heveslilik, güven ve empati için sırasıyla -1.20, -0.77, -0.90, -0.84 ve -1.05 bulunmuştur