SERUM GLUCOCORTICOID-INDUCIBLE KINASE-1(SGK1) LEVELS IN PATIENTS WITH PSORIATIC ARTHRITIS

WOS: 000435456000097

The relationship of serum vitamin D receptor levels with disease activity and clinical parameters in patients with ankylosing spondylitis

Objectives: The aim of this study was to investigate the relationship between serum vitamin D receptor (SVDR) levels and disease activity parameters in patients with ankylosing spondylitis (AS). Patients and methods: Between July 2016 and January 2017, a total of 62 patients (51 males, 11 females; mean age 36.5 +/- 12.8 years; range, 23 to 49 years) with AS and 32 healthy volunteers (25 males, 7 females; mean age 41.57 +/- 13.6 years; range, 26 to 48 years) were included in the study. The SVDR levels were measured using the enzyme-linked immunosorbent assay. Erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) levels were recorded. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores were used to assess disease activity. Results: Although there was no significant difference between the patient and control groups (p=0.66), SVDR levels were significantly elevated in patients with active AS (BASDAI score >= 4) (p=0.01). The SVDR levels significantly increased in AS patients with peripheral joint involvement and enthesitis (p=0.01, p=0.05, respectively). The SVDR levels significantly elevated in patients treated with non-steroidal anti-inflammatory drugs, compared to those treated with biological agents and control group (p=0.01, p=0.03, respectively). The SVDR levels were positively correlated with the BASDAI, CRP and ESR in the patient group (p=0.01, r=0.751; p=0.01, r=0.75; p=0.01, r=0.81, respectively). Conclusion: Our study results suggest that serum SVDR levels are associated with the disease activity and clinical parameters in patients with AS. Based on these findings, SVDR level may be used as a marker of disease activity in AS

The role of vitamin D receptor gene polymorphisms in the pathogenesis of Behcet's disease: A case-control study in Turkish population

Background Behcet's disease (BD) is an inflammatory disorder characterized by oral aphthous lesions, uveitis, and genital ulcerations. The vitamin D receptor (VDR) has a crucial role in the pathogenesis of this disease because it mediates the functions of vitamin D in the immune system. Alterations of VDR expression related to polymorphic alleles of the VDR gene may play a pathogenic role in BD and BD's clinical presentations. Methods 150 BD patients and 150 healthy controls were included and genotyping was carried out by polymerase chain reaction/restriction fragment length polymorphism. Results Significant differences between patients and controls in rs1544410, rs2228570, and rs731236 genotypes were observed (respectively, p = 0.04, p = 0.007, p = 0.012). The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045). Conclusion VDR gene polymorphisms may possibly have a role in the pathogenesis of BD through their effects on VDR expression and may be associated with the increased risk of several clinical findings

Chronic inhibition of tumor necrosis factor-alpha with infliximab improves myocardial deformation in parallel with aortic elasticity in rheumatoid arthritis

Conclusion: Myocardial deformation is impaired in RA patients and is related to aortic stiffness. Chronic inhibition of TNF alpha improves LV deformation in association with aortic elasticity

Effect of Long-Term TNF-alpha Inhibition with Infliximab on Left Ventricular Torsion in Patients with Rheumatoid Arthritis

Conclusions: RA is characterized by increased LVtor. Long term TNF-alpha inhibition improves LV longitudinal and radial systolic deformation and decreases LVtor

Effect of Long-Term TNF-alpha Inhibition with Infliximab on Left Ventricular Torsion in Patients with Rheumatoid Arthritis

Conclusions: RA is characterized by increased LVtor. Long term TNF-alpha inhibition improves LV longitudinal and radial systolic deformation and decreases LVtor