Two different causes in a patient with distal symmetric axonal polyneuropathy: Churg-Strauss syndrome and multiple myeloma, coincidental or associated with each other?

WOS: 000404610500026PubMed ID: 2833204

A controlled study of sexual function in men with cannabis use disorder: A brief report

WOS: 000413430200006Background: Studies about the effects of cannabis on male sexual function have contradictory results. This contradiction is thought to depend on the subjective assessment of the patient or on the use of non-validated questionnaires. Aims: The objective of this study was to evaluate the sexual function of male patients with cannabis use disorder by a validated questionnaire and to compare them with a healthy control group. Methods: 47 male patients with cannabis use disorder and without any comorbid psychiatric disorders were included in this study. The education level and age of the patients were matched with 33 healthy male participants. In addition to the sociodemographic characteristics, the pattern of cannabis use and sexual life were also questioned. Sexual function was evaluated by International Index of Erectile Function. Results: The scores of erectile function and orgasmic function in the patient group were found significantly lower than the control group. Erectile dysfunction was significantly more frequently reported in the patient group than the control group. Sexual desire, intercourse satisfaction, and overall satisfaction scores did not differ significantly between groups. Conclusions: Our findings indicated that sexual function should be inquired in men with cannabis use disorder. These findings could be used in prevention studies focused on cannabis use disorder

Is BDNF-Val66Met polymorphism associated with psychotic experiences and psychotic disorder outcome? Evidence from a 6 years prospective population-based cohort study

WOS: 000459452000003PubMed ID: 29785763There is little research on genetic risk for the extended psychosis phenotype ranging from psychotic experiences (PEs) to psychotic disorders (PDs). In this general population-based prospective cohort study, the longitudinal associations between BDNF-Val66Met polymorphism and the different levels of the extended psychosis phenotype were investigated. Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighborhoods at baseline (n = 4011). A nested case-control study (n = 366) recruited individuals with PEs and PDs as well as individuals with no psychotic symptoms. In this subgroup, blood sampling for genetic analysis and assessment of environmental exposures were carried out, followed by clinical re-appraisal at follow-up 6 years later (n = 254). The BDNF-Val66Met polymorphism was significantly associated with the extended psychosis phenotype. The pattern of the association was that the BDNF-Val66Met polymorphism impacted in a dose-response but extra-linear fashion, with stronger impact at the PD end of the extended psychosis phenotype. Associations were still significant after adjusting for sociodemographic factors and environmental exposures including life events, childhood adversity, socioeconomic status, urbanicity, and cannabis use. The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.Turkiye Bilimsel ve Teknolojik Arastirma KurumuTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107S053, 112S476]Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Numbers: 107S053 and 112S47

Evaluation of attempted older adults suicides admitted to a University Hospital Emergency Department: Izmir study

WOS: 000417621600058PubMed ID: 29121560Introduction: Advanced age is one of the risk factors for attempting suicide. Suicide attempts are one of the reasons for elderly patients to admit emergency services. The aim of this study was to investigate the relationship between suicidal behavior and sociodemographic factors and concurrent somatic diseases. Methods: The medical records of patients aged 60 years and over who presented to the emergency department of our university hospital for attempted suicide between the dates of January 1, 2007 and December 31, 2015 were screened retrospectively. Individuals recorded as cases of suicide on the forensic case report form were identified, the data recorded at our hospital were obtained, and telephone interviews were conducted to acquire any missing data. Results: A total of 63 patients with a mean age of 65.88 years were included in the study. A large proportion of the suicide attempts occurred in the years 2014 and 2015. Overall, 23.8% of the patients had a previous history of suicide attempt. Overdose was the method in 74.6% of the suicide attempts, and 70.2% were impulsive; 63.5% of the patients had a history of psychiatric disease. The most common psychopathology was major depressive disorder. Conclusion: We found that suicide attempts were more common among older adults with a history of depression, that approximately one in four had previously attempted suicide, and that the majority of individuals attempting suicide chose to use their own medication

Autopercepção das condições bucais em uma população de idosos da cidade de Montes Claros, Minas Gerais, Brasil

O objetivo deste trabalho foi investigar a autopercepção das condições bucais em uma população de idosos não-institucionalizados da cidade de Montes Claros. A pesquisa objetivou ainda verificar a associação existente entre a autopercepção e as características sociodemográficas, necessidades odontológicas, condições sistêmicas e uso de medicações nos indivíduos pesquisados. Trata-se de um estudo descritivo transversal com uma amostra do tipo aleatória simples (n=204). A autopercepção foi avaliada através do Índice de Determinação da Saúde Bucal Geriátrica (GOHAI). De acordo com os resultados obtidos, 53,9% dos idosos eram do gênero feminino; 53,9% não eram casados; 57,8% possuíam idade entre 60 e 69 anos; 84,9% não eram brancos; 69,1% eram analfabetos; 56,4% tinham renda per capita > ½ salário mínimo; 59,8% foram ao dentista há três anos ou mais; 52,9% realizaram a última consulta no serviço público; 63,7% eram edêntulos; 67,2% usavam algum tipo de prótese; 77% necessitavam de prótese e 81,4% não possuíam alteração de tecido mole. Destes, 31,9% apresentavam doença periodontal; o CPO-D médio foi 29,39; 91,2% apresentavam alguma doença sistêmica; 78,4% usavam medicação e a maior parte (36,3%) autopercebeu a condição bucal como regular. Na análise multivariada, foi verificado que os idosos que necessitavam de algum tipo de prótese dentária e não possuíam cônjuge apresentaram maiores chances de ter uma baixa autopercepção das condições bucais. De maneira geral, percebeu-se que a maioria dos idosos possuía uma condição socioeconômica satisfatória; apresentava necessidades odontológicas normativas; tinha alguma doença sistêmica; usava medicação e autopercebeu a saúde bucal como regular ou ruim, condizente com a avaliação profissional