Shades of Grey: Ethical Dilemmas

No abstract available

Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum.

Study of the distribution of the p21 ras oncogene product as demonstrated by monoclonal antibody Y13-259 shows this protein to be apparently present in all epithelial populations of both premalignant and malignant tumours and throughout the normal foetal and adult epithelial crypt population in the colorectum. Metastatic tumour in liver shows a similar staining pattern which is less intense however than in the surrounding normal hepatocytes. Our results suggest that the presence of this protein is a widespread feature of normal cellular metabolism in certain cell types and is not restricted to those actively involved in cellular proliferation. It appears, furthermore, that neither cells at different stages of carcinogenesis nor those representing variants of a malignant phenotype can be identified using this particular antibody

The orbital poles of Milky Way satellite galaxies: a rotationally supported disc-of-satellites

Available proper motion measurements of Milky Way (MW) satellite galaxies are used to calculate their orbital poles and projected uncertainties. These are compared to a set of recent cold dark-matter (CDM) simulations, tailored specifically to solve the MW satellite problem. We show that the CDM satellite orbital poles are fully consistent with being drawn from a random distribution, while the MW satellite orbital poles indicate that the disc-of-satellites of the Milky Way is rotationally supported. Furthermore, the bootstrapping analysis of the spatial distribution of theoretical CDM satellites also shows that they are consistent with being randomly drawn. The theoretical CDM satellite population thus shows a significantly different orbital and spatial distribution than the MW satellites, most probably indicating that the majority of the latter are of tidal origin rather than being DM dominated sub-structures. A statistic is presented that can be used to test a possible correlation of satellite galaxy orbits with their spatial distribution.Comment: Accepted for publication in Ap

The energy budget in Rayleigh-Benard convection

It is shown using three series of Rayleigh number simulations of varying aspect ratio AR and Prandtl number Pr that the normalized dissipation at the wall, while significantly greater than 1, approaches a constant dependent upon AR and Pr. It is also found that the peak velocity, not the mean square velocity, obeys the experimental scaling of Ra^{0.5}. The scaling of the mean square velocity is closer to Ra^{0.46}, which is shown to be consistent with experimental measurements and the numerical results for the scaling of Nu and the temperature if there are strong correlations between the velocity and temperature.Comment: 5 pages, 3 figures, new version 13 Mar, 200

Time-Varying Gravitomagnetism

Time-varying gravitomagnetic fields are considered within the linear post-Newtonian approach to general relativity. A simple model is developed in which the gravitomagnetic field of a localized mass-energy current varies linearly with time. The implications of this temporal variation of the source for the precession of test gyroscopes and the motion of null rays are briefly discussed.Comment: 10 pages; v2: slightly expanded version accepted for publication in Class. Quantum Gra

Differentially rotating disks of dust: Arbitrary rotation law

In this paper, solutions to the Ernst equation are investigated that depend on two real analytic functions defined on the interval [0,1]. These solutions are introduced by a suitable limiting process of Backlund transformations applied to seed solutions of the Weyl class. It turns out that this class of solutions contains the general relativistic gravitational field of an arbitrary differentially rotating disk of dust, for which a continuous transition to some Newtonian disk exists. It will be shown how for given boundary conditions (i. e. proper surface mass density or angular velocity of the disk) the gravitational field can be approximated in terms of the above solutions. Furthermore, particular examples will be discussed, including disks with a realistic profile for the angular velocity and more exotic disks possessing two spatially separated ergoregions.Comment: 23 pages, 3 figures, submitted to 'General Relativity and Gravitation