The cosmic evolution of radio-AGN feedback to z=1

This paper presents the first measurement of the radio luminosity function of 'jet-mode' (radiatively-inefficient) radio-AGN out to z=1, in order to investigate the cosmic evolution of radio-AGN feedback. Eight radio source samples are combined to produce a catalogue of 211 radio-loud AGN with 0.5<z<1.0, which are spectroscopically classified into jet-mode and radiative-mode (radiatively-efficient) AGN classes. Comparing with large samples of local radio-AGN from the Sloan Digital Sky Survey, the cosmic evolution of the radio luminosity function of each radio-AGN class is independently derived. Radiative-mode radio-AGN show an order of magnitude increase in space density out to z~1 at all luminosities, consistent with these AGN being fuelled by cold gas. In contrast, the space density of jet-mode radio-AGN decreases with increasing redshift at low radio luminosities (L_1.4 < 1e24 W/Hz) but increases at higher radio luminosities. Simple models are developed to explain the observed evolution. In the best-fitting models, the characteristic space density of jet-mode AGN declines with redshift in accordance with the declining space density of massive quiescent galaxies, which fuel them via cooling of gas in their hot haloes. A time delay of 1.5-2 Gyr may be present between the quenching of star formation and the onset of jet-mode radio-AGN activity. The behaviour at higher radio luminosities can be explained either by an increasing characteristic luminosity of jet-mode radio-AGN activity with redshift (roughly as (1+z) cubed) or if the jet-mode radio-AGN population also includes some contribution of cold-gas-fuelled sources seen at a time when their accretion rate was low. Higher redshifts measurements would distinguish between these possibilities.Comment: Accepted for publication in MNRA

Structural Causes of Right Bundle Branch Block—Time for a Closer Look?

Right bundle branch block is an electrocardiographic phenomenon with specific criteria

The effectiveness and safety of antifibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis

Introduction: The Antifibrinolytic Trialists Collaboration aims to increase knowledge about the effectiveness and safety of antifibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article presents the statistical analysis plan for an IPD meta-analysis of the effects of antifibrinolytics for acute intracranial haemorrhage. Methods: The protocol for the IPD meta-analysis has been registered with PROSPERO (CRD42016052155). We will conduct an individual patient data meta-analysis of randomised controlled trials with 1000 patients or more assessing the effects of antifibrinolytics in acute intracranial haemorrhage. We will assess the effect on two co-primary outcomes: 1) death in hospital at end of trial follow-up, and 2) death in hospital or dependency at end of trial follow-up. The co-primary outcomes will be limited to patients treated within three hours of injury or stroke onset. We will report treatment effects using odds ratios and 95% confidence intervals. We use logistic regression models to examine how the effect of antifibrinolytics vary by time to treatment, severity of intracranial bleeding, and age. We will also examine the effect of antifibrinolytics on secondary outcomes including death, dependency, vascular occlusive events, seizures, and neurological outcomes. Secondary outcomes will be assessed in all patients irrespective of time of treatment. All analyses will be conducted on an intention-to-treat basis. Conclusions: This IPD meta-analysis will examine important clinical questions about the effects of antifibrinolytic treatment in patients with intracranial haemorrhage that cannot be answered using aggregate data. With IPD we can examine how effects vary by time to treatment, bleeding severity, and age, to gain better understanding of the balance of benefit and harms on which to base recommendations for practice

Mineralogy of some soils from the Amazonia Sedimentary Basin.

ABSTRACT: The Amazonia Forest is an important biome that possesses great diversity of fauna and flora, which can play a significant role in several science areas, specially, the gene reserve for the future of humankind. Nevertheless, it is a very poorly understood environment, particularly the basis of this ecosystem, its soils. This study was conducted to gain insight in the mineralogy of important soils classes of the Amazonia sedimentary basin. The soils in the upland position in the landscape are developed from tertiary sediments belonging to the Alter do Chão series and those in the floodplain position are derived from quaternary, more specifically, Holocene´s sediments. Sand, silt and clay fractions were separated and X-ray diffraction analysis was conducted. Very simple mineralogy composed basically of quartz in the coarser fractions and kaolinite, goethite and anatase for the finer fraction was found for the Oxisol, the Ultisol and the Entisol from an upland toposequence but differences in kaolinite crystallography could be noticed among them. Gibbsite was virtually absent, in spite of the advanced degree of development of most of these soils. More distinctive mineralogy was revealed for the soils developed in the more recent sediments with quartz and feldspars in the sand and silt fractions and a suite of 2:1 minerals also appearing in their clay fraction, besides kaolinite and goethite. In one upland soil petroplinthite is the main feature and its mineralogy reflected its environment of formation which is usually associated with level to gently sloping areas with fluctuating water table

The origin of the Guitar pulsar

Among a sample of 140 OB associations and clusters, we want to identify probable parent associations for the Guitar pulsar (PSR B2224+65) which would then also constrain its age. For this purpose, we are using an Euler-Cauchy technique treating the vertical component of the galactic potential to calculate the trajectories of the pulsar and each association into the past. To include errors we use Monte-Carlo simulations varying the initial parameters within their error intervals. The whole range of possible pulsar radial velocities is taken into account during the simulations. We find that the Guitar pulsar most probably originated from the Cygnus OB3 association ~0.8 Myr ago inferring a current radial velocity of v_r~-30 km/s, consistent with the inclination of its bow shock.Comment: 4 pages, 1 figure, 3 table

Adverse effects of biologic anti-inflammatory agents on the respiratory system : a review

The therapy of autoimmune rheumatological conditions has undergone significant changes with the introduction of biologic antiinflammatory agents including cytokine antagonists and agents that interfere with the function of T and B cells or those that inhibit intracellular enzymes such as Janus kinase (JAK). Although useful to control inflammation, these agents may be associated with drug-induced lung disease, which may be difficult to differentiate from pulmonary disorders caused by the underlying autoimmune diseases. This review aims to provide a description of lung disease, both infectious and non-infectious, that may be induced by the administration of biologic anti-inflammatory agents with emphasis on inhibitors of tumour necrosis factor, interleukin-1, interleukin-6 and JAK.https://journals.co.za/journal/m.ajtccmam2022Internal Medicin

Making big steps in trajectories

We consider the solution of initial value problems within the context of hybrid systems and emphasise the use of high precision approximations (in software for exact real arithmetic). We propose a novel algorithm for the computation of trajectories up to the area where discontinuous jumps appear, applicable for holomorphic flow functions. Examples with a prototypical implementation illustrate that the algorithm might provide results with higher precision than well-known ODE solvers at a similar computation time