Genomic Organization of the Human Arpp Gene

A novel ankyrin-repeated protein, Arpp, is specifically expressed in skeletal and cardiac muscles. Arpp protein is homologous, in its amino acid sequences (52.7% identity), to Carp protein which is proposed to be a putative genetic marker for cardiac hypertrophy. In this study, we isolated the human Arpp gene by screening a human genomic library and analyzed the genomic structure and its 5' flanking region. The Arpp gene was found to encompass a sequence of 11 kb and to consist of 9 exons. The translational initiation site and the stop codon were found to be located at exon 1 and exon 9, respectively. Each exon from 5 to 8 was found to encode 1 of the 4 ankyrin-like domains, respectively. The 2.7 kb upstream of exon 1 was sequenced. The TATA box was identified 29 bp upstream of the transcriptional start site, and multiple putative regulatory elements including the E box and upstream stimulating factor-1 were distributed within the proximal promoter regions. Since these elements were also found in the promoter region of the mouse Arpp gene, they may play an important role in the transcriptional regulation of both human and murine Arpp genes

Association of remnant-like lipoprotein particles cholesterol with "oketsu" syndrome

Increasing evidence suggests that remnant-like lipoprotein particles cholesterol (RLP-C) is an independent cardio-vascular disease (CVD) risk factor. High levels of RLP-C exhibit findings similar to those of "oketsu" syndrome on blood rheology studies and scanning electron micrographs. We measured levels of RLP-C in plasma samples and "oketsu" scores obtained in 199 randomly selected subjects. The coefficient of correlation between levels of RLP-C and "oketsu" score was highly significant (r=0.581, P<0.0001). This finding suggests that presence of excess RLP-C in the blood resembles closely "oketsu" syndrome which we have shown to be an independent risk factor for CVD. レムナント様リポ蛋白コレステロール(RLP-C)が独立した心血管疾患(CVD)の危険因子であることが明らかになりつつある。RLP-Cが高値であると,血流動態上も電子顕微鏡像上でも瘀血病態と類似している。我々は無作為に選んだ199例より得られた血漿RLP-C値と瘀血スコアを測定した。RLP-C値と瘀血スコアの間には有意な相関が認められた(r=0.581,P<0.0001)。このことより,CVDに対する独立危険因子である高RLP-C血症が瘀血病態と酷似していることを示唆する結果となった

Enhancement of Tritium Release Rate from Ceramic Breeders with Impregnated Catalytic Additives

In most current designs of D-T fusion reactor blankets employing ceramic breeder materials， the use of a helium sweep gas containing O.1％of hydrogen is contemplated to extract tritium efficiently via isotopic exchange reactions． However， at lower temperatures， the release process of tritium from the breeders is rather slow. For this reason， there is still a need to develop techniques that contribute to the enhancement of the recovery of bred tritium． In order to obtain an improved recovery of tritium from a blanket over wide ranges of temperature， the effect of catalytically active metal additives on the heterogeneous isotope exchange reactions at the breeder-sweep gas interface was examined， Platinum and palladium were deposited on solid breeder material pebbles（Li_4SiO_4）by the incipient wet impregnation method． Cold experiments with hydrogen and predeuterated water were performed using packed bed reactors and gas chromatographic analysis systems． Out of pile tritium release experiments were also conducted． using ceramic breeders irradiated in a research reactor． The experimental results reveal that the addition of catalytic additive metals is very effective to increase the tritium release rate from ceramic breeder materials especially at comparatively lower temperatures

触媒金属を担持させたセラミック増殖材からのトリチウム放出率の増加

In most current designs of D-T fusion reactor blankets employing ceramic breeder materials， the use of a helium sweep gas containing O.1％of hydrogen is contemplated to extract tritium efficiently via isotopic exchange reactions． However， at lower temperatures， the release process of tritium from the breeders is rather slow. For this reason， there is still a need to develop techniques that contribute to the enhancement of the recovery of bred tritium． In order to obtain an improved recovery of tritium from a blanket over wide ranges of temperature， the effect of catalytically active metal additives on the heterogeneous isotope exchange reactions at the breeder-sweep gas interface was examined， Platinum and palladium were deposited on solid breeder material pebbles（Li_4SiO_4）by the incipient wet impregnation method． Cold experiments with hydrogen and predeuterated water were performed using packed bed reactors and gas chromatographic analysis systems． Out of pile tritium release experiments were also conducted． using ceramic breeders irradiated in a research reactor． The experimental results reveal that the addition of catalytic additive metals is very effective to increase the tritium release rate from ceramic breeder materials especially at comparatively lower temperatures

Low energy radioactivity BG model in Super-Kamiokande detector from SK-IV data

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Follow-up of GWTC-2 gravitational wave events with neutrinos from the Super-Kamiokande detector

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