Pore-Scale Dynamics of Liquid CO\u3csub\u3e2\u3c/sub\u3e–Water Displacement in 2D Axisymmetric Porous Micromodels Under Strong Drainage and Weak Imbibition Conditions: High-Speed μPIV Measurements

Resolving pore-scale transient flow dynamics is crucial to understanding the physics underlying multiphase flow in porous media and informing large-scale predictive models. Surface properties of the porous matrix play an important role in controlling such physics, yet interfacial mechanisms remain poorly understood, in part due to a lack of direct observations. This study reports on an experimental investigation of the pore-scale flow dynamics of liquid CO2 and water in two-dimensional (2D) circular porous micromodels with different surface characteristics employing high-speed microscopic particle image velocimetry (μPIV). The design of the micromodel minimized side boundary effects due to the limited size of the domain. The high-speed μPIV technique resolved the spatial and temporal dynamics of multiphase flow of CO2 and water under reservoir-relevant conditions, for both drainage and imbibition scenarios. When CO2 displaced water in a hydrophilic micromodel (i.e., drainage), unstable capillary fingering occurred and the pore flow was dominated by successive pore-scale burst events (i.e., Haines jumps). When the same experiment was repeated in a nearly neutral wetting micromodel (i.e., weak imbibition), flow instability and fluctuations were virtually eliminated, leading to a more compact displacement pattern. Energy balance analysis indicates that the conversion efficiency between surface energy and external work is less than 30%, and that kinetic energy is a disproportionately smaller contributor to the energy budget. This is true even during a Haines jump event, which induces velocities typically two orders of magnitude higher than the bulk velocity. These novel measurements further enabled direct observations of the meniscus displacement, revealing a significant alteration of the pore filling mechanisms during drainage and imbibition. While the former typically featured burst events, which often occur only at one of the several throats connecting a pore, the latter is typically dominated by a cooperative filling mechanism involving simultaneous invasion of a pore from multiple throats. This cooperative filling mechanism leads to merging of two interfaces and releases surface energy, causing instantaneous high-speed events that are similar, yet fundamentally different from, burst events. Finally, pore-scale velocity fields were statistically analyzed to provide a quantitative measure of the role of capillary effects in these pore flows

Coherent structures in oscillatory flows within the laminar-to-turbulent transition regime for smooth and rough walls

This is an Accepted Manuscript of an article published by Taylor & Francis Group in [Journal of hydraulic research] on [2016], available online at: http://www.tandfonline.com/10.1080/00221686.2016.1174960We investigate coherent structures present in oscillatory boundary layers over smooth and rough beds for Reynolds numbers between 103 and 104, in the transition to turbulence regime. A two-camera 2D- particle image velocimetry (PIV) system was used to visualize coherent structures in an oscillatory-flow tunnel. The obtained results show that smooth-bed flow is populated by vortex-tube structures that are formed due to the Kelvin–Helmholtz instability. Three types of coherent structures are observed in the rough-wall experiments: vortices randomly distributed in space; turbulent bursts – spatial structures without a clear shape compared to vortices but with a longer life than the former; and shear layers of vortices originating due to flow separation from some of the grains on the bed. The reported study contributes to the description of coherent structures in oscillatory flows that are captured with the PIV technique, particularly a new structure in flows over rough beds in the transition to turbulence regime.Peer ReviewedPostprint (author's final draft

Characteristics of large-scale and superstructure motions in a turbulent boundary layer overlying complex roughness

The structural attributes of turbulent flow over a complex roughness topography are explored using high-frame-rate stereo particle-image velocimetry measurements in the wall-normal–spanwise plane. The roughness under consideration was replicated from a turbine blade damaged by deposition of foreign materials and contains a broad range of topographical scales arranged in a highly irregular manner. Previous results from Barros and Christensen [Observations of turbulent secondary flows in a rough-wall boundary layer. J Fluid Mech. 2014;748] revealed strong spanwise heterogeneity in the flow attributed to the formation of roughness-induced turbulent secondary flows identified by spanwise-alternating low- and high-momentum flow pathways (HMP & LMP, respectively) in the mean flow marked by enhanced Reynolds stresses and turbulent kinetic energy. Frequency spectra of streamwise velocity at fixed wall-normal location presented herein also display strong dependence on spanwise position. In particular, the roughness promotes enhanced energy content of the large-scale and smaller-scale motions (as opposed to very-large-scale ones). Depending on spanwise position, pre-multiplied spectra highlight significant modification of the energy content of the very large-scale motions (superstructures) due to roughness compared to smooth-wall flow. Of note, a shift in both TKE and RSS content to shorter streamwise scales at an LMP was noted, while less of an impact was found coincident with an HMP

Forward-Backward Correlations and Event Shapes as probes of Minimum-Bias Event Properties

Measurements of inclusive observables, such as particle multiplicities and momentum spectra, have already delivered important information on soft-inclusive ("minimum-bias") physics at the Large Hadron Collider. In order to gain a more complete understanding, however, it is necessary to include also observables that probe the structure of the studied events. We argue that forward-backward (FB) correlations and event-shape observables may be particulary useful first steps in this respect. We study the sensitivity of several different types of FB correlations and two event shape variables - transverse thrust and transverse thrust minor - to various sources of theoretical uncertainty: multiple parton interactions, parton showers, colour (re)connections, and hadronization. The power of each observable to furnish constraints on Monte Carlo models is illustrated by including comparisons between several recent, and qualitatively different, PYTHIA 6 tunes, for pp collisions at sqrt(s) = 900 GeV.Comment: 13 page

Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate

<p>Abstract</p> <p>Background</p> <p>High dietary intake of selenium or soybean isoflavones reduces prostate cancer risk. These components each affect androgen-regulated gene expression. The objective of this work was to determine the combined effects of selenium and isoflavones on androgen-regulated gene expression in rat prostate.</p> <p>Methods</p> <p>Male Noble rats were exposed from conception until 200 days of age to diets containing an adequate (0.33-0.45 mg/kg diet) or high (3.33-3.45 mg/kg) concentration of selenium as Se-methylselenocysteine and a low (10 mg/kg) or high (600 mg/kg) level of isoflavones in a 2 × 2 factorial design. Gene expression in the dorsolateral prostate was determined for the androgen receptor, for androgen-regulated genes, and for Akr1c9, whose product catalyzes the reduction of dihydrotestosterone to 5alpha-androstane-3alpha, 17beta-diol. Activity of hepatic glutathione peroxidise 1 and of prostatic 5alpha reductase were also assayed.</p> <p>Results</p> <p>There were no differences due to diet in activity of liver glutathione peroxidase activity. Total activity of 5alpha reductase in prostate was significantly lower (<it>p </it>= 0.007) in rats fed high selenium/high isoflavones than in rats consuming adequate selenium/low isoflavones. High selenium intake reduced expression of the androgen receptor, Dhcr24 (24-dehydrocholesterol reductase), and Abcc4 (ATP-binding cassette sub-family C member 4). High isoflavone intake decreased expression of Facl3 (fatty acid CoA ligase 3), Gucy1a3 (guanylate cyclase alpha 3), and Akr1c9. For Abcc4 the combination of high selenium/high isoflavones had a greater inhibitory effect than either treatment alone. The effects of selenium on gene expression were always in the direction of chemoprevention</p> <p>Conclusion</p> <p>These results suggest that combined intake of high selenium and high isoflavones may achieve a greater chemopreventive effect than either compound supplemented individually.</p

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution

International audienc

A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission

Abstract 1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model (Df(h1q21)/+) and characterized it in a broad test battery focusing on schizophrenia-related assays. Df(h1q21)/+ mice displayed increased hyperactivity in response to amphetamine challenge and increased sensitivity to the disruptive effects of amphetamine and phencyclidine hydrochloride (PCP) on prepulse inhibition. Probing of the direct dopamine (DA) pathway using the DA D1 receptor agonist SKF-81297 revealed no differences in induced locomotor activity compared to wild-type mice, but Df(h1q21)/+ mice showed increased sensitivity to the DA D2 receptor agonist quinpirole and the D1/D2 agonist apomorphine. Electrophysiological characterization of DA neuron firing in the ventral tegmental area revealed more spontaneously active DA neurons and increased firing variability in Df(h1q21)/+ mice, and decreased feedback reduction of DA neuron firing in response to amphetamine. In a range of other assays, Df(h1q21)/+ mice showed no difference from wild-type mice: gross brain morphology and basic functions such as reflexes, ASR, thermal pain sensitivity, and motor performance were unaltered. Similarly, anxiety related measures, baseline prepulse inhibition, and seizure threshold were unaltered. In addition to the central nervous system-related phenotypes, Df(h1q21)/+ mice exhibited reduced head-to tail length, which is reminiscent of the short stature reported in humans with 1q21.1 deletion. With aspects of both construct and face validity, the Df(h1q21)/+ model may be used to gain insight into schizophrenia-relevant alterations in dopaminergic transmission

An Energy-Water Corridor Along the US/Mexico Border: Changing the \u27Conversation\u27

Over the last decade, migration has become a divisive issue around the world. A large number of countries have erected barriers along their borders to prevent migration, leading to geopolitical tension. Climate change effects will likely exacerbate migration tensions, which will require bold and creative solutions to this difficult social predicament. Here we detail a plan to construct an energy-water corridor along a border that has been the focus of much attention recently: The U.S.-Mexico border. Our proposed solution helps to alleviate some of the negative effects of climate change, while providing energy and economic stimulus to an area that begs for sustainable development. The energy-water corridor will take advantage of the unique renewable energy resources along the border states and will use state-of-the-art water desalination and treatment systems to provide the resources for economic development in the region