Cremation practices and the creation of monument complexes: the Neolithic cremation cemetery at Forteviot, Strathearn, Perth & Kinross, Scotland, and its comparanda

Around the beginning of the 3rd millennium cal bc a cremation cemetery was established at Forteviot, central Scotland. This place went on to become one of the largest monument complexes identified in Mainland Scotland, with the construction of a palisaded enclosure, timber structures, and a series of henge monuments and other enclosures. The cemetery was established between 3080 and 2900 cal bc, probably in the 30th century cal bc, which is contemporary with the cremation cemetery at Stonehenge. Nine discrete deposits of cremated bone, representing the remains of at least 18 people, were identified. In most instances they were placed within cut features and, in one case, a series of cremation deposits was associated with a broken standing stone. This paper includes the first detailed assessment of the cremated remains at Forteviot and the features associated with the cemetery, and explores how the establishment of this cemetery may have been both a catalyst and inspiration for the elaborate monument building and prolonged acts of remembrance that occurred at this location over a period of almost 1000 years. The paper also outlines the parallels for Forteviot across Britain and, for the first time, draws together the dating evidence (including Bayesian modelling) for this major category of evidence for considering the nature of late 4th/early 3rd millennium cal bc society. The results and discussion have wide implications and resonances for contemplating the establishment and evolution of monument complexes in prehistoric Britain and beyond

Cremation practices and the creation of monument complexes: the Neolithic cremation cemetery at Forteviot, Strathearn, Perth & Kinross, Scotland, and its comparanda

Around the beginning of the 3rd millennium cal bc a cremation cemetery was established at Forteviot, central Scotland. This place went on to become one of the largest monument complexes identified in Mainland Scotland, with the construction of a palisaded enclosure, timber structures, and a series of henge monuments and other enclosures. The cemetery was established between 3080 and 2900 cal bc, probably in the 30th century cal bc, which is contemporary with the cremation cemetery at Stonehenge. Nine discrete deposits of cremated bone, representing the remains of at least 18 people, were identified. In most instances they were placed within cut features and, in one case, a series of cremation deposits was associated with a broken standing stone. This paper includes the first detailed assessment of the cremated remains at Forteviot and the features associated with the cemetery, and explores how the establishment of this cemetery may have been both a catalyst and inspiration for the elaborate monument building and prolonged acts of remembrance that occurred at this location over a period of almost 1000 years. The paper also outlines the parallels for Forteviot across Britain and, for the first time, draws together the dating evidence (including Bayesian modelling) for this major category of evidence for considering the nature of late 4th/early 3rd millennium cal bc society. The results and discussion have wide implications and resonances for contemplating the establishment and evolution of monument complexes in prehistoric Britain and beyond

Who tolerates tax increases? : Age and gender in the raising of Japanese consumption taxes

日本の政党は、国の借金増大という喫緊の課題に直面し、歳出削減や増税に対する一般の人々の支持を取り付けようと懸命になっている。本論文では、1985年から2015年にかけて実施された世論調査の結果を用いながら、消費税への人々の支持が費用および便益の認識に左右されているということを示す。具体的には、公共財（特に社会保障プログラム）に資金を供給するために税金が必要だと回答者が考えていれば、消費税への支持率は高くなる。また、高齢者は納税の便益をすぐに受けられる立場にあるため、増税に対する許容度は年齢とともに上昇する。しかし女性は男性に比べて許容度は低くなっており、これは消費税の引き上げによる価格上昇に対して女性の方がより敏感であるからだと考えられる。Facing alarming public debt, Japanese political parties struggle to muster public support for painful expenditure cuts and tax increases. Using public opinion surveys between 1985 and 2015, we show that public support for consumption taxes is conditional on perceptions of costs and benefits. Approval is higher when respondents believe that taxes are necessary to fund public goods, particularly social insurance programs. We also find that tolerance for tax hikes increases with age, as the elderly are closer to receiving the benefits of tax payments, but lower for women, likely because they are more sensitive to price increases imposed by the consumption tax.特集　社会規範と世論の形

Are Gestational Age, Birth Weight, and Birth Length Indicators of Favorable Fetal Growth Conditions? A Structural Equation Analysis of Filipino Infants

The fetal origin hypothesis emphasizes the life-long health impacts of prenatal conditions. Birth weight, birth length, and gestational age are indicators of the fetal environment. However, these variables often have missing data and are subject to random and systematic errors caused by delays in measurement, differences in measurement instruments, and human error. With data from the Cebu (Philippines) Longitudinal Health and Nutrition Survey, we use structural equation models (SEMs), to explore random and systematic errors in these birth outcome measures, to analyze how maternal characteristics relate to birth outcomes, and to take account of missing data. We assess whether birth weight, birth length, and gestational age are influenced by a single latent variable that we call Favorable Fetal Growth Conditions (FFGC) and if so, which variable is most closely related to FFGC. We find that a model with FFGC as a latent variable fits as well as a less parsimonious model that has birth weight, birth length, and gestational age as distinct individual variables. We also demonstrate that birth weight is more reliably measured than is gestational age. FFGC were significantly influenced by taller maternal stature, better nutritional stores indexed by maternal arm fat and muscle area during pregnancy, higher birth order, avoidance of smoking and maternal age 20-35 years. Effects of maternal characteristics on newborn weight, length and gestational age were largely indirect, operating through FFCG

Cremation Practices and the Creation of Monument Complexes : The Neolithic Cremation Cemetery at Forteviot, Strathearn, Perth & Kinross, Scotland, and its comparanda

This paper is the result of the hard work and contribution of many people. In particular we would like to thank the substantial contributions made to this paper by Alison Sheridan, Stephany Leach and Derek Hamilton; they also kindly read over and commented on earlier versions of this paper, but all errors remain our own. The excavations at Forteviot were the work of dozens of students from Glasgow and Aberdeen Universities and local volunteers. Dupplin Estate kindly allowed us to work at Forteviot. Fieldwork and post-excavation analysis was largely funded by Historic Environment Scotland (then Historic Scotland), and we very much benefited from the support of colleagues within the SERF Project – Ewan Campbell, Steve Driscoll and Tessa Poller. Figures 1 and 2 were prepared by Lorraine McEwan, while Figures 3 and 16 were drawn by Alison Sandison. Figures 11 to 15 were prepared by Derek Hamilton, while the drawings in Figures 7 and 8 were undertaken by Marion O’Neil. Historic Environment Scotland have provided grant aid for the publication and illustration of this paper.Peer reviewedPublisher PD

Identification of a Homology-Independent Linchpin Domain Controlling Mouse and Bank Vole Prion Protein Conversion

Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrPSc, onto the cell-expressed conformer, PrPC. Here we study the conversion of PrPC to PrPSc using a recombinant mouse PrPSc conformer (mouse protein-only recPrPSc) as a unique tool that can convert bank vole but not mouse PrPC substrates in vitro. Thus, its templating ability is not dependent on sequence homology with the substrate. In the present study, we used chimeric bank vole/mouse PrPC substrates to systematically determine the domain that allows for conversion by Mo protein-only recPrPSc. Our results show that that either the presence of the bank vole amino acid residues E227 and S230 or the absence of the second N-linked glycan are sufficient to allow PrPC substrates to be converted by Mo protein-only recPrPSc and several native infectious prion strains. We propose that residues 227 and 230 and the second glycan are part of a C-terminal domain that acts as a linchpin for bank vole and mouse prion conversion

High intensity aerobic exercise training improves deficits of cardiovascular autonomic function in a rat model of type 1 diabetes mellitus with moderate hyperglycemia

© 2016 Kenneth N. Grisé et al. Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1 diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a relatable insulin-treated model of T1DM would induce deficits in cardiovascular (CV) autonomic function more reflective of clinical results and if exercise training could prevent those deficits. Sixty-four rats were divided into four groups: sedentary control (C), sedentary T1DM (D), control exercise (CX), or T1DM exercise (DX). Diabetes was induced via multiple low-dose injections of streptozotocin and blood glucose was maintained at moderate hyperglycemia (9-17 mM) through insulin supplementation. Exercise training consisted of daily treadmill running for 10 weeks. Compared to C, D had blunted baroreflex sensitivity, increased vascular sympathetic tone, increased serum neuropeptide Y (NPY), and decreased intrinsic heart rate. In contrast, DX differed from D in all measures of CAN (except NPY), including heart rate variability. These findings demonstrate that this T1DM model elicits deficits and exercise-mediated improvements to CV autonomic function which are reflective of clinical T1DM

Bridging the GUI gap with reactive values and relations

There are at present two ways to write GUIs for functional code. One is to use standard GUI toolkits, with all the benefits they bring in terms of feature completeness, choice of platform, conformance to platform-specific look-and-feel, long-term viability, etc. However, such GUI APIs mandate an imperative programming style for the GUI and related parts of the application. Alternatively, we can use a functional GUI toolkit. The GUI can then be written in a functional style, but at the cost of foregoing many advantages of standard toolkits that often will be of critical importance. This paper introduces a light-weight framework structured around the notions of reactive values and reactive relations . It allows standard toolkits to be used from functional code written in a functional style. We thus bridge the gap between the two worlds, bringing the advantages of both to the developer. Our framework is available on Hackage and has been been validated through the development of non-trivial applications in a commercial context, and with different standard GUI toolkits

Correlation between Quantitative PCR and Culture-Based Methods for Measuring Enterococcus spp. over Various Temporal Scales at Three California Marine Beaches

ABSTRACT Several studies have examined how fecal indicator bacteria (FIB) measurements compare between quantitative PCR (qPCR) and the culture methods it is intended to replace. Here, we extend those studies by examining the stability of that relationship within a beach, as affected by time of day and seasonal variations in source. Enterococcus spp. were quantified at three southern California beaches in the morning and afternoon using two qPCR assays, membrane filtration, and defined-substrate testing. While qPCR and culture-based measurements were consistently and significantly correlated, strength of the correlation varied both among and within beaches. Correlations were higher in the morning (0.45 < ρ < 0.74 [ P < 0.002]) than in the afternoon (0.18 < ρ < 0.45 [ P < 0.021]) and higher when the fecal contamination was concentrated (0.38 < ρ < 0.83 [ P < 0.001]) than when it was diffuse (0.19 < ρ < 0.34 [ P < 0.003]). The ratios of culture-based and qPCR results (CFU or most probable number [MPN] per calibrator cell equivalents [CCE]) also varied spatially and temporally. Ratios ranged between 0.04 and 0.85 CFU or MPN per CCE and were lowest at the beach affected by diffuse pollution. Patterns in the ratios over the course of the day were dissimilar across beaches, increasing with time at one beach and decreasing at another. The spatial and temporal variability we observed indicate that the empirical relationship between culture-based and qPCR results is not universal, even within a beach