2,460 research outputs found
The next frontier: Fostering innovation by improving health data access and utilization
Beneath most lively policy debates sit dry-as-dust theoretical and methodological discussions. Current disputes over the EU Adaptive Pathways initiative and the proposed US 21st Century Cures Act may ultimately rest on addressing arcane issues of data curation, standardization, and utilization. Improved extraction of inform ation on the safety and effectiveness of drugs-in-use must parallel adjustments in evidence requirements at the time of licensing. To do otherwise may compromise safety and efïŹcacy in the name of fostering innovation
The formation of bulges, discs and two-component galaxies in the CANDELS Survey at z < 3
We examine a sample of 1495 galaxies in the CANDELS fields to determine the evolution of two-component galaxies, including bulges and discs, within massive galaxies at the epoch 1 < z < 3 when the Hubble sequence forms. We fit all of our galaxiesâ light profiles with a single Sersic fit, as well as with a combination of exponential and Sersic profiles. The latter is done in order to describe a galaxy with an inner and an outer component, or bulge and disc component. We develop and use three classification methods (visual, F-test and the residual flux fraction) to separate our sample into one-component galaxies (disc/spheroids-like galaxies) and two-component galaxies (galaxies formed by an âinner partâ or bulge and an âouter partâ or disc). We then compare the results from using these three different ways to classify our galaxies. We find that the fraction of galaxies selected as two-component galaxies increases on average 50 per cent from the lowest mass bin to the most massive galaxies, and decreases with redshift by a factor of 4 from z = 1 to 3. We find that single Sersic âdisc-likeâ galaxies have the highest relative number densities at all redshifts, and that two-component galaxies have the greatest increase and become at par with Sersic discs by z = 1. We also find that the systems we classify as two-component galaxies have an increase in the sizes of their outer components, or âdiscsâ, by about a factor of 3 from z = 3 to 1.5, while the inner components or âbulgesâ stay roughly the same size. This suggests that these systems are growing from the inside out, whilst the bulges or protobulges are in place early in the history of these galaxies. This is also seen to a lesser degree in the growth of single âdisc-likeâ galaxies versus âspheroid-likeâ galaxies over the same epoch
The mass evolution of the first galaxies: stellar mass functions and star formation rates at in the CANDELS GOODS-South field
We measure new estimates for the galaxy stellar mass function and star
formation rates for samples of galaxies at using data in
the CANDELS GOODS South field. The deep near-infrared observations allow us to
construct the stellar mass function at directly for the first time.
We estimate stellar masses for our sample by fitting the observed spectral
energy distributions with synthetic stellar populations, including nebular line
and continuum emission. The observed UV luminosity functions for the samples
are consistent with previous observations, however we find that the observed
- M relation has a shallow slope more consistent with a constant
mass to light ratio and a normalisation which evolves with redshift. Our
stellar mass functions have steep low-mass slopes (),
steeper than previously observed at these redshifts and closer to that of the
UV luminosity function. Integrating our new mass functions, we find the
observed stellar mass density evolves from at to at . Finally, combining the measured UV continuum
slopes () with their rest-frame UV luminosities, we calculate dust
corrected star-formation rates (SFR) for our sample. We find the specific
star-formation rate for a fixed stellar mass increases with redshift whilst the
global SFR density falls rapidly over this period. Our new SFR density
estimates are higher than previously observed at this redshift.Comment: 28 pages, 23 figures, 2 appendices. Accepted for publication in
MNRAS, August 7 201
Evaluating the potential for the environmentally sustainable control of foot and mouth disease in Sub-Saharan Africa
Strategies to control transboundary diseases have in the past generated unintended negative consequences for both the environment and local human populations. Integrating perspectives from across disciplines, including livestock, veterinary and conservation sectors, is necessary for identifying disease control strategies that optimise environmental goods and services at the wildlife-livestock interface. Prompted by the recent development of a global strategy for the control and elimination of foot-and-mouth disease (FMD), this paper seeks insight into the consequences of, and rational options for potential FMD control measures in relation to environmental, conservation and human poverty considerations in Africa. We suggest a more environmentally nuanced process of FMD control that safe-guards the integrity of wild populations and the ecosystem dynamics on which human livelihoods depend while simultaneously improving socio-economic conditions of rural people. In particular, we outline five major issues that need to be considered: 1) improved understanding of the different FMD viral strains and how they circulate between domestic and wildlife populations; 2) an appreciation for the economic value of wildlife for many African countries whose presence might preclude the country from ever achieving an FMD-free status; 3) exploring ways in which livestock production can be improved without compromising wildlife such as implementing commodity-based trading schemes; 4) introducing a participatory approach involving local farmers and the national veterinary services in the control of FMD; and 5) finally the possibility that transfrontier conservation might offer new hope of integrating decision-making at the wildlife-livestock interface
Survey of Parasites In Threatened Stocks of Coho Salmon (Oncorhynchus kisutch) In Oregon By Examination of Wet Tissues and Histology
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