Functionalized Polycarbonate Commercial Filters for Water Purification

Can commerercially available filtration membranes be easily functionalized in such a way to enhence the removal the charged contaminants in the water treatment process? The literature demonstrates there have been two pioneering works that demonstrated that Ultrathin Self-Assembled Nanoparticle (USANP) membranes (composed of ~5 nm diameter metallic gold nanoparticles surrounded by organic ligands) when applied to commercial membranes displayed charge sensitive rejection to molecular dyes and also have the ability to charge modify the openings in commercial filters. The rejection mechanisms in these works are proposed to be either size dependent or charged based. Recent experimental results have demonstrated that the supporting filter for these USANP membranes can be functionalized solely with highly charged molecular dye Direct Red 80 using no USANP membranes. After functionalization with direct red 80 alone, average rejection for tested molecular dyes at a concentration of 145 µM increased from 31.8 % to 85.6 % even without the addition of a USANP layer. This indicates that dyes themselves are capable of functionalizing the commercial membranes providing an additional method to enhanced rejection of charged contaminants. This poster highlights the efforts made by a Preservice and Early Career Research for Teachers (PERT) team and an Undergraduate student who was awarded an Summer Undergraduate Research Experience Award to measure the rejection results of these two different functionalization methods. Knowledge gained from these experiments may allow for enhanced rejection of charged based contaminants in polluted waters

Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.OBJECTIVE Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in type 1 diabetes is due to abnormal activity of the respiratory chain and an altered mitochondrial proteome. RESEARCH DESIGN AND METHODS Proteomic analysis using stable isotope labeling with amino acids in cell culture (SILAC) determined expression of proteins in mitochondria from dorsal root ganglia (DRG) of control, 22-week-old streptozotocin (STZ)-diabetic rats, and diabetic rats treated with insulin. Rates of oxygen consumption and complex activities in mitochondria from DRG were measured. Fluorescence imaging of axons of cultured sensory neurons determined the effect of diabetes on mitochondrial polarization status, oxidative stress, and mitochondrial matrix-specific reactive oxygen species (ROS). RESULTS Proteins associated with mitochondrial dysfunction, oxidative phosphorylation, ubiquinone biosynthesis, and the citric acid cycle were downregulated in diabetic samples. For example, cytochrome c oxidase subunit IV (COX IV; a complex IV protein) and NADH dehydrogenase Fe-S protein 3 (NDUFS3; a complex I protein) were reduced by 29 and 36% (P < 0.05), respectively, in diabetes and confirmed previous Western blot studies. Respiration and mitochondrial complex activity was significantly decreased by 15 to 32% compared with control. The axons of diabetic neurons exhibited oxidative stress and depolarized mitochondria, an aberrant adaption to oligomycin-induced mitochondrial membrane hyperpolarization, but reduced levels of intramitochondrial superoxide compared with control. CONCLUSIONS Abnormal mitochondrial function correlated with a downregulation of mitochondrial proteins, with components of the respiratory chain targeted in lumbar DRG in diabetes. The reduced activity of the respiratory chain was associated with diminished superoxide generation within the mitochondrial matrix and did not contribute to oxidative stress in axons of diabetic neurons. Alternative pathways involving polyol pathway activity appear to contribute to raised ROS in axons of diabetic neurons under high glucose concentration.This work was supported by grants from the Juvenile Diabetes Research Foundation (#1-2008-280) and the National Institutes of Health to R.T.D. (grants NS-054847 and DK-073594). E.A. was supported by a grant from the National Science and Engineering Research Council (#3311686-06) to P.F. and subsequently by a postgraduate scholarship from the Manitoba Health Research Council. S.K.R.C. and E.Z. were supported by grants to P.F. from the Canadian Institutes for Health Research (#MOP-84214) and the Juvenile Diabetes Research Foundation (#1-2008-193). D.R.S. was supported by a grant to P.F. from the Manitoba Health Research Council. This work was also funded by the St. Boniface General Hospital and Research Foundation

The Grizzly, February 2, 1979

Frat Beating Draws Administrative Fire • New Frat Gathers Steam • Holiday Thefts: Negligence or Lack of Concern? • In Memoriam • Judiciary Board Revival • Cultural Kaleidoscope • Letters to the Editor: Snack shop complaint • Roving Reporter: Greaseband opinions • Dishroom Profile: Roy Schuetz, Man or Myth? • Grease Is The Word • Nicolette Larson Debuts In Style • USGA Elections • Portrait of the Professor: Dr. Conrad E. Kruse • Raquetball Review • Bio Club Spawned • R.A. Applications Available; Ruby Seeks Editor • Gymnasts Place Third In Tourney • Bears Turning Corner • Slavin Breaks Record Mermaids Lose • Wrestlers Manhandle Mules • Badminton Drops Onehttps://digitalcommons.ursinus.edu/grizzlynews/1011/thumbnail.jp

Koinonia

Spotlight FeaturesHas Facebook Jumped the Shark?, Rick Zomer The Good, the Bad, and the Ugly of Virtual Community, David Johnstone Screenagers: How Technology is Changing the Way we Interact with Students, Tim Elmore \u27In Loco Parentis\u27 Revisited, Gene C. Fant Jr. ACSD News: From Location to Interest: ACSD Considers Move from Regional to Collaboratives Model, Edee Schulze, Connie Sjoberg, Mike Broberg, David A. Kennedy, Nicole Hoefle Thinking TheologicallyKeeping Faith: Serving Students or the Kingdom, Michael and Stephanie Santarosa Book ReviewsEncouraging Authenticity and Spirituality in Higher Education, reviewed by Jason M. Morris My Freshman Year, Heidi Johnston FeaturesThe President\u27s Corner; Editor\u27s Deskhttps://pillars.taylor.edu/acsd_koinonia/1002/thumbnail.jp

UNLV Jazz 2008 Fall Performances

Program listing performers and works performe

Antitumour and antimalarial activity of artemisinin–acridine hybrids

Artemisinin–acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2–4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle

Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trials

BACKGROUND: Randomized controlled trials play a central role in evidence-based practice, but recruitment of participants, and retention of them once in the trial, is challenging. Moreover, there is a dearth of evidence that research teams can use to inform the development of their recruitment and retention strategies. As with other healthcare initiatives, the fairest test of the effectiveness of a recruitment strategy is a trial comparing alternatives, which for recruitment would mean embedding a recruitment trial within an ongoing host trial. Systematic reviews indicate that such studies are rare. Embedded trials are largely delivered in an ad hoc way, with interventions almost always developed in isolation and tested in the context of a single host trial, limiting their ability to contribute to a body of evidence with regard to a single recruitment intervention and to researchers working in different contexts. METHODS/DESIGN: The Systematic Techniques for Assisting Recruitment to Trials (START) program is funded by the United Kingdom Medical Research Council (MRC) Methodology Research Programme to support the routine adoption of embedded trials to test standardized recruitment interventions across ongoing host trials. To achieve this aim, the program involves three interrelated work packages: (1) methodology - to develop guidelines for the design, analysis and reporting of embedded recruitment studies; (2) interventions - to develop effective and useful recruitment interventions; and (3) implementation - to recruit host trials and test interventions through embedded studies. DISCUSSION: Successful completion of the START program will provide a model for a platform for the wider trials community to use to evaluate recruitment interventions or, potentially, other types of intervention linked to trial conduct. It will also increase the evidence base for two types of recruitment intervention. TRIAL REGISTRATION: The START protocol covers the methodology for embedded trials. Each embedded trial is registered separately or as a substudy of the host trial

Student Employment: Linking College and the Workplace

The focus of National Student Employment Association (formerly the National Association of Student Employment Administrators, or NASEA) publications has always been on students in transition. From the freshman moving from high school to higher education, to the senior attempting the transition to professional employment and financial independence, we always have explored how students can better accomplish these linking experiences. Student employment is a hybrid, serving as a bridge between work and school, and ultimately, a link between school and full-time work. Student employment links elements of financial aid, career development, academic learning, experiential education, and personal development. Student employment, in all of these ways, is a bridge, moving the student from point A to point B. Because of this variety, any publication on student employment must necessarily speak to diverse themes. We have organized this publication in four sections: an introduction followed by three themed sections.https://digitalcommons.brockport.edu/bookshelf/1000/thumbnail.jp

The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial.

BACKGROUND: Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to participate. Improving readability, ease of comprehension and presentation may assist with improved participant recruitment. The Systematic Techniques for Assisting Recruitment to Trials (MRC START) study aimed to develop and evaluate interventions to improve trial recruitment. This study aimed to assess the effectiveness of an optimised participant information brochure and cover letter developed by MRC START regarding response and participant recruitment rates. METHODS: We conducted a study within a trial (SWAT) embedded in the EarlyCDT Lung Cancer Scotland (ECLS) trial that aimed to assess the effectiveness of a new test in reducing the incidence of patients with late-stage lung cancer at diagnosis compared with standard care. Potential participants approached for ECLS were randomised to receive the original participant information brochure and accompanying letter (control group) or optimised versions of these materials which had undergone user testing and a process of re-writing, re-organisation and professional graphic design (intervention group). The primary outcome was the number of patients recruited to ECLS. The secondary outcome was the proportion of patients expressing an interest in participating in ECLS. RESULTS: In total, 2262 patients were randomised, 1136 of whom were sent the intervention materials and 1126 of whom were sent the control materials. The proportion of patients enrolled and randomised into ECLS was 180 of 1136 (15.8%) in the intervention group and 176 of 1126 (15.6%) in the control group (OR = 1.016, 95% CI, 0.660 to 1.564). The proportion of patients who positively responded to the invitation was 224 of 1136 (19.7%) in the intervention group and 205 of 1126 (18.2%) in the control group (OR = 1.103, 95% CI, 0.778 to 1.565). CONCLUSIONS: Optimised patient information materials made little difference to the proportion of patients positively responding to a trial invitation or to the proportion subsequently randomised to the host trial. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01925625 . Registered on 15 August 2015. Study Within A Trial, SWAT-23. Registered on 12 April 2016