The Unemployment Trap Meets the Age-Earning Profile.

The relative costs of taking employment or receiving welfare are usually understood through comparisons of a person’s social security entitlements and their wage alternative, known as replacement rates. In some situations it appears that the additional income from working is negligible, and this is said to constitute an “unemployment trap”. However, conventional replacement rates ignore the fact that age-earnings profiles slope upward through the acquisition of labour market experience. We offer a dynamic reinterpretation and compare alternative calculations for Australia in 2000. The usual and incorrect approach exaggerates significantly the likelihood of unemployment traps, but the presence of children mitigates considerably, and can even reverse, this assessment.unemployment traps, social security, age-earnings profiles, wages

Krüppel-like factors in cancer progression: three fingers on the steering wheel

Kruppel-like factors (KLFs) comprise a highly conserved family of zinc finger transcription factors, that are involved in a plethora of cellular processes, ranging from proliferation and apoptosis to differentiation, migration and pluripotency. During the last few years, evidence on their role and deregulation in different human cancers has been emerging. This review will discuss current knowledge on Kruppel-like transcription in the epithelial-mesenchymal transition (EMT), invasion and metastasis, with a focus on epithelial cancer biology and the extensive interface with pluripotency. Furthermore, as KLFs are able to mediate different outcomes, important influences of the cellular and microenvironmental context will be highlighted. Finally, we attempt to integrate diverse findings on KLF functions in EMT and stem cell biology to fit in the current model of cellular plasticity as a tool for successful metastatic dissemination

Average crack-front velocity during subcritical fracture propagation in a heterogeneous medium

We study the average velocity of crack fronts during stable interfacial fracture experiments in a heterogeneous quasibrittle material under constant loading rates and during long relaxation tests. The transparency of the material (polymethylmethacrylate) allows continuous tracking of the front position and relation of its evolution to the energy release rate. Despite significant velocity fluctuations at local scales, we show that a model of independent thermally activated sites successfully reproduces the large-scale behavior of the crack front for several loading conditions

No Effect of EVA and TPU Custom Foot Orthoses on Mechanical Asymmetries during Acute Intense Fatigue

From Crossref journal articles via Jisc Publications RouterHistory: epub 2023-03-11, issued 2023-03-11Article version: VoRPublication status: PublishedFunder: QNRF; FundRef: 10.13039/100008982; Grant(s): NPRP 4-760-3-217This study examined the impact of custom foot orthoses made of ethyl-vinyl acetate (EVA) and expanded thermoplastic polyurethane (TPU) materials, both compared to a control condition (CON; shoes only), on mechanical asymmetries during repeated treadmill sprints. Eighteen well-trained male runners executed eight, 5-s sprints (rest: 25 s) on an instrumented motorized treadmill in three footwear conditions (EVA, TPU, and CON). We evaluated the group mean asymmetry scores using the ‘symmetry angle’ (SA) formula, which assigns a score of 0% for perfect symmetry and a score of 100% for perfect asymmetry. There was no condition (all p ≥ 0.053) or time (p ≥ 0.074) main effects, nor were there any significant time × condition interactions on SA scores for any variables (p ≥ 0.640). Mean vertical, horizontal, and total forces presented mean SA values (pooled values for the three conditions) of 2.6 ± 1.9%, 2.9 ± 1.6%, and 2.4 ± 1.8%, respectively. Mean SA scores were ~1–3% for contact time (1.5 ± 0.5%), flight time (3.0 ± 0.3%), step frequency (1.1 ± 0.5%), step length (1.9 ± 0.7%), vertical stiffness (2.1 ± 0.9%), and leg stiffness (2.4 ± 1.1%). Mean SA scores were ~2–6.5% for duration of braking (4.1 ± 1.6%) and propulsive (2.4 ± 1.0%) phases, and peak braking (6.2 ± 2.9%) and propulsive (2.1 ± 1.4%) forces. In well-trained runners facing intense fatigue, wearing custom foot orthoses did not modify the observed low-to-moderate natural stride mechanical asymmetries.pubpu

Custom foot orthoses improve performance, but do not modify the biomechanical manifestation of fatigue, during repeated treadmill sprints

From PubMed via Jisc Publications RouterWe determined the effect of custom foot orthotics manufactured from ethyl-vinyl acetate (EVA) and expanded thermoplastic polyurethane (TPU) materials, both compared to a control condition (CON; shoes only) during repeated sprints on running mechanical alterations. Eighteen males performed eight, 5-s sprints with 25-s recovery on an instrumented sprint treadmill in three footwear conditions (EVA, TPU and CON). Mechanical data consisted of continuous (step-by-step) measurement of running kinetics and kinematics, which were averaged for each sprint for further analysis. Distance ran in 5 s decreased from first to last sprint (P < 0.001), yet with higher sprints 1-8 values for both EVA (P = 0.004) and TPU (P = 0.018) versus CON. Regardless of footwear condition, mean horizontal forces, step frequency, vertical and leg stiffness decreased from sprint 1 to sprint 8 (all P < 0.001). Duration of the propulsive phase was globally shorter for both EVA (P = 0.002) and TPU (P = 0.021) versus CON, while braking phase duration was similar (P = 0.919). In the horizontal direction, peak propulsive (P < 0.001), but not braking (P = 0.172), forces also decreased from sprint 1 to sprint 8, independently of conditions. Compared to shoe only, wearing EVA or TPU custom foot orthotics improved repeated treadmill sprint ability, yet provided similar fatigue-induced changes in mechanical outcomes.120inpressinpres

Kinetics of thorium and particle cycling along the U.S. GEOTRACES North Atlantic Transect

© The Author(s), 2017. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Deep Sea Research Part I: Oceanographic Research Papers 125 (2017): 106-128, doi:10.1016/j.dsr.2017.05.003.The high particle reactivity of thorium has resulted in its widespread use in tracing processes impacting marine particles and their chemical constituents. The use of thorium isotopes as tracers of particle dynamics, however, largely relies on our understanding of how the element scavenges onto particles. Here, we estimate apparent rate constants of Th adsorption (k1), Th desorption (k−1), bulk particle degradation (β-1), and bulk particle sinking speed (w) along the water column at 11 open-ocean stations occupied during the GEOTRACES North Atlantic Section (GA03). First, we provide evidence that the budgets of Th isotopes and particles at these stations appear to be generally dominated by radioactive production and decay sorption reactions, particle degradation, and particle sinking. Rate parameters are then estimated by fitting a Th and particle cycling model to data of dissolved and particulate 228,230,234Th, 228Ra, particle concentrations, and 234,238U estimates based on salinity, using a nonlinear programming technique. We find that the adsorption rate constant (k1) generally decreases with depth across the section: broadly, the time scale 1/k1 averages 1.0 yr in the upper 1000 m and (1.4–1.5) yr below. A positive relationship between k1 and particle concentration (P) is found, i.e., , k1 ∝ Pb where b ≥ 1, consistent with the notion that k1 increases with the number of surface sites available for adsorption. The rate constant ratio, K = k1/(k-1 + β-1), which measures the collective influence of rate parameters on Th scavenging, averages 0.2 for most stations and most depths. We clarify the conditions under which K/P is equivalent to the distribution coefficient, KD, test that the conditions are met at the stations, and find that decreases with P, in line with a particle concentration effect (dKD/dP < 0). In contrast to the influence of colloids as envisioned by the Brownian pumping hypothesis, we provide evidence that the particle concentration effect arises from the joint effect of P on the rate constants for thorium attachment to, and detachment from, particles.We acknowledge the U.S. National Science Foundation for providing funding for this study (grant OCE-1232578) and for U.S. GEOTRACES North Atlantic section ship time, sampling, and data analysis. The U.S. NSF also supported the generation of 230Th data (OCE-0927064 to LDEO, OCE-O092860 to WHOI, and OCE-0927754 to UMN) and 228,234Th data (OCE-0925158 to WHOI)

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer

Cell motility and invasion initiate metastasis. However, only a subpopulation of cancer cells within a tumor will ultimately become invasive. Due to this stochastic and transient nature, in an experimental setting, migrating and invading cells need to be isolated from the general population in order to study the gene expression profiles linked to these processes. This report describes microarray analysis on RNA derived from migrated or invaded subpopulations of triple negative breast cancer cells in a Transwell set-up, at two different time points during motility and invasion, pre-determined as “early” and “late” in real-time kinetic assessments. Invasion- and migration-related gene expression signatures were generated through comparison with non-invasive cells, remaining at the upper side of the Transwell membranes. Late-phase signatures of both invasion and migration indicated poor prognosis in a series of breast cancer data sets. Furthermore, evaluation of the genes constituting the prognostic invasion-related gene signature revealed Krüppel-like factor 9 (KLF9) as a putative suppressor of invasive growth in breast cancer. Next to loss in invasive vs non-invasive cell lines, KLF9 also showed significantly lower expression levels in the “early” invasive cell population, in several public expression data sets and in clinical breast cancer samples when compared to normal tissue. Overexpression of EGFP-KLF9 fusion protein significantly altered morphology and blocked invasion and growth of MDA-MB-231 cells in vitro. In addition, KLF9 expression correlated inversely with mitotic activity in clinical samples, indicating anti-proliferative effects

Spatial variation of subduction zone fluids during progressive subduction: Insights from Serpentinite Mud Volcanoes

Geological processes at subduction zones control seismicity, plutonism and volcanism, and geochemical cycling between the oceans, crust, and mantle. The down-going plate experiences metamorphism, and the associated dehydration and fluid flow alters the physical properties of the plate interface and mantle wedge, as well as controlling the composition of material descending into the mantle. Any direct study of slab evolution during subduction is inhibited by the prohibitive depths at which these processes occur. To examine these processes we use serpentinite mud volcanoes in the Mariana forearc, that permit sampling of serpentinite materials and their pore waters that ascend from the subduction channel. We present new pore water chemical data from the summit and flanks of three serpentinite mud volcanoes that were drilled during International Ocean Discovery Program Expedition 366 which are reflective of reactions within the crust and mantle during the early, shallow (<20 km) stages of subduction. We show, via thermodynamic modelling, that our new data on the evolution of pore water chemical compositions reflect mineralogical characteristics of a predominately basaltic source from the downgoing Pacific Plate. However, a component from sedimentary sources is likely, especially for those mud volcanoes near the trench. Other potential slab-derived constituents, such as lithospheric serpentinite, carbonate-rich sediments, or seamount basalts with an intraplate geochemical character, are not required to explain our results. Our results indicate that with progressive subduction the lawsonite-epidote mineral transformation boundary at ∼250 °C may help drive slab carbonate destabilisation, despite its apparent thermodynamic stability at such temperatures and projected pressures (∼300 °C and ∼0.6 GPa). New dissolved gas data also point to primary thermodynamic controls over methane/ethane production within the subduction channel as depths-to-slab increase. Our findings provide direct evidence for the progressive mineralogical and chemical evolution of a subducting oceanic plate, which liberates a progressively evolving fluid phase into the subduction channel