Courseware in academic library user education: A literature review from the GAELS Joint Electronic Library Project

The use of courseware for information skills teaching in academic libraries has been growing for a number of years. In order to create effective courseware packages to support joint electronic library activity at Glasgow and Strathclyde Universities, the GAELS project conducted a literature review of the subject. This review discovered a range of factors common to successful library courseware implementations, such as the need for practitioners to feel a sense of ownership of the medium, a need for courseware customization to local information environments, and an emphasis on training packages for large bodies of undergraduates. However, we also noted underdeveloped aspects worthy of further attention, such as treatment of pedagogic issues in library computer‐aided learning (CAL) implementations and use of hypertextual learning materials for more advanced information skills training. We describe how these findings shaped the packages produced by the project and suggest ways forward for similar types of implementation

Human Rights in Latin America: Human Rights in Cuba

In 1959, Fidel Castro established a Cuban socialist state closely aligned with the Soviet Union. The Soviet Union\u27s collapse brought an end to Soviet economic support which, combined with the U.S. embargo, created an economic crisis in the early 1990s. The Cuban government\u27s instability and desire to maintain control overrides the individual rights of its citizens. These events are the background for the lack of fundamental human rights in Cuba today

Policy Recommendations for Meeting the Grand Challenge to Create Social Responses to a Changing Environment

This brief was created forSocial Innovation for America’s Renewal, a policy conference organized by the Center for Social Development in collaboration with the American Academy of Social Work & Social Welfare, which is leading theGrand Challenges for Social Work initiative to champion social progress. The conference site includes links to speeches, presentations, and a full list of the policy briefs

Company-commissioned independent inquiries: A case for applied research

This paper calls for deeper research on company-commissioned independent inquiries (CCIIs). Over the past 10 years, CCIIs have been occasionally used to respond to complex stakeholder issues in the context of resource extraction. These are typically high-stakes environments: there is a need to make good decisions in a complex situation, where the available facts are contested, and where human rights risks are present. Our preliminary review suggests that there is much to understand about these innovative processes from the perspective of conflict management, community relations and organisational learning. This paper considers seven international CCIIs commissioned by global mining companies and describes them - both in terms of the methodologies used and the resulting outcomes. Perspectives from across the stakeholder spectrum are required to understand what principles, methodologies or conditions could have contributed to better outcomes for the parties involved. Ensuring that principles can be applied in different contexts, across a range of issues, is pivotal to these inquiry processes being activated with integrity

Increased pCO2 changes the lipid production in important aquacultural feedstock algae Isochrysis galbana, but not in Tetraselmis suecica

Increased anthropogenic CO2 emissions are leading to an increase in CO2 uptake by the world's oceans and seas, resulting in ocean acidification with a decrease in global ocean water pH by as much as 0.3–0.4 units by the year 2100. The direct effects of changing pCO2 on important microalgal feedstocks are not as well understood. Few studies have focused on lipid composition changes in specific algal species in response to ocean acidification and yet microalgae are an indispensable food source for various marine species, including juvenile shellfish. Isochrysis galbana and Tetraselmis suecica are widely used in aquaculture as feeds for mussels and other shellfish. The total lipid contents and concentrations of I. galbana and T. suecica were investigated when grown under present day (400 ppm) and ocean acidification conditions (1000 ppm) to elucidate the impact of increasing pCO2 on an important algae feedstock. Total lipids, long-chain alkenones (LCAs) and alkenoates decreased at 1000 ppm in I. galbana. I. galbana produces higher lipids than T. suecica, and is perhaps as a result more impacted by the change in carbon available for lipid production under higher pCO2. I. galbana is an important feedstock, more easily assimilated for growth in juvenile shellfish and reductions in lipid composition may prove problematic for the growth of future shellfish aquaculture. Our findings suggest that higher pCO2 impacts on algal lipid growth are species specific and warrant further study. It is therefore vital to examine the impact of high CO2 on algal lipid production, especially those commercial shellfish feed varieties to predict future impacts on commercial aquaculture

The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility.

BackgroundThe p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 and the ESCRT adaptor Alix, respectively, and are critical for efficient budding of virus particles from the plasma membrane. L domain-2 is thought to be functionally redundant to PTAP. To identify possible other functions of L domain-2, we examined this motif in dominant viruses that emerged in a group of 14 women who had detectable levels of HIV-1 in both plasma and genital tract despite a history of current or previous antiretroviral therapy.ResultsRemarkably, variants possessing mutations or rare polymorphisms in the highly conserved L domain-2 were identified in seven of these women. A mutation in a conserved residue (S40A) that does not reduce Gag interaction with Alix and therefore did not reduce budding efficiency was further investigated. This mutation causes a simultaneous change in the Pol reading frame but exhibits little deficiency in Gag processing and virion maturation. Whether introduced into the HIV-1 NL4-3 strain genome or a model protease (PR) precursor, S40A reduced production of mature PR. This same mutation also led to high level detection of two extended forms of PR that were fairly stable compared to the WT in the presence of IDV at various concentrations; one of the extended forms was effective in trans processing even at micromolar IDV.ConclusionsOur results indicate that L domain-2, considered redundant in vitro, can undergo mutations in vivo that significantly alter PR function. These may contribute fitness benefits in both the absence and presence of PR inhibitor

Risk and Performance Analyses Supporting Closure of WMA C at the Hanford Site in Southeast Washington

The Office of River Protection under the U.S. Department of Energy (DOE) is pursuing closure of the Single-Shell Tank (SST) Waste Management Area 0NMA) C as stipulated by the Hanford Federal Facility Agreement and Consent Order (HFFACO) under federalrequirements and work tasks will be done under the State-approved closure plans and permits. An initial step in meeting the regulatory requirements is to develop a baseline risk assessment representing current conditions based on available characterization data and information collected at the WMA C location. The baseline risk assessment will be supporting a Resource Conservation and Recovery Act of 1976 (RCRA) Field Investigation (RFI)/Corrective Measures Study (CMS) for WMA closure and RCRA corrective action. Complying with the HFFACO conditions also involves developing a long-term closure Performance Assessment (PA) that evaluates human health and environmental impacts resulting from radionuclide inventories in residual wastes remaining in WMA C tanks and ancillary equipment. This PAis being developed to meet the requirements necessary for closure authorization under DOE Order 435.1 and Washington State Hazardous Waste Management Act. To meet the HFFACO conditions, the long-term closure risk analysis will include an evaluation of human health and environmental impacts from hazardous chemical inventories along with other performance Comprehensive Environmental Response, Compensation, and Liability Act Appropriate and Applicable Requirements (CERCLA ARARs) in residualwastes left in WMA C facilities after retrieval and removal. This closure risk analysis is needed to needed to comply with the requirements for permitted closure. Progress to date in developing a baseline risk assessment of WMA C has involved aspects of an evaluation of soil characterization and groundwater monitoring data collected as a part of the RFI/CMS and RCRA monitoring. Developing the long-term performance assessment aspects has involved the construction of detailed numericalmodels of WMA C using the Subsurface Transport Over Multiple Phases (STOMP(C)) computer code, the development of a technical approach for abstraction of a range of representative STOMP(C) simulations into a system-level modelbased on the GoldSim0 system-levelmodelsoftware. The STOMP(C)-based models will be used to evaluate local-scale impacts and closed facility performance over a sufficient range of simulations to allow for development of the system-level model of the WMA C. The GoldSim0-based system-level model will be used to evaluate overall sensitivity of modeled parameters and the estimate the uncertainty in potentialfuture impacts from a closed WMA C facility