Measuring Population Transmission Potential for HIV: An Alternative Metric of Transmission Risk in Men who have Sex with Men (MSM) in the US

Background Various metrics for HIV burden and treatment success [e.g. HIV prevalence, community viral load (CVL), population viral load (PVL), percent of HIV-positive persons with undetectable viral load] have important public health limitations for understanding disparities. Methods and Findings Using data from an ongoing HIV incidence cohort of black and white men who have sex with men (MSM), we propose a new metric to measure the prevalence of those at risk of transmitting HIV and illustrate its value. …See full text for complete abstract

Analysis of the 5'UTR of HCV genotype 3 grown in vitro in human B cells, T cells, and macrophages

<p>Abstract</p> <p>Background</p> <p>Previously, we have reported the isolation and molecular characterization of human Hepatitis C virus genotype 1 (HCV-1) from infected patients. We are now reporting an analysis of HCV obtained from patients infected with HCV genotype 3 (HCV-3) as diagnosed by clinical laboratories.</p> <p>Results</p> <p>HCV was cultured <it>in vitro </it>using our system. HCV RNA was isolated from patients' blood and from HCV cultured in various cell types for up to three months. The 5'UTR of these isolates were used for comparisons. Results revealed a number of sequence changes as compared to the serum RNA. The HCV RNA produced efficiently by infected macrophages, B-cells, and T-cells had sequences similar to HCV-1, which suggests that selection of the variants was performed at the level of macrophages. Virus with sequences similar to HCV-1 replicated better in macrophages than HCV having a 5'UTR similar to HCV-3.</p> <p>Conclusions</p> <p>Although HCV-3 replicates in cell types such as B-cells, T-cells, and macrophages, it may require a different primary cell type for the same purpose. Therefore, in our opinion, HCV-3 does not replicate efficiently in macrophages, and patients infected with HCV-3 may contain a population of HCV-1 in their blood.</p

Collisional damping rates for plasma waves

The distinction between the plasma dynamics dominated by collisional transport versus collective processes has never been rigorously addressed until recently. A recent paper [Yoon et al., Phys. Rev. E 93, 033203 (2016)] formulates for the first time, a unified kinetic theory in which collective processes and collisional dynamics are systematically incorporated from first principles. One of the outcomes of such a formalism is the rigorous derivation of collisional damping rates for Langmuir and ion-acoustic waves, which can be contrasted to the heuristic customary approach. However, the results are given only in formal mathematical expressions. The present Brief Communication numerically evaluates the rigorous collisional damping rates by considering the case of plasma particles with Maxwellian velocity distribution function so as to assess the consequence of the rigorous formalism in a quantitative manner. Comparison with the heuristic ("Spitzer") formula shows that the accurate damping rates are much lower in magnitude than the conventional expression, which implies that the traditional approach over-estimates the importance of attenuation of plasma waves by collisional relaxation process. Such a finding may have a wide applicability ranging from laboratory to space and astrophysical plasmas.Comment: 5 pages, 2 figures; Published in Physics of Plasmas, volume/Issue 23/6. Publisher: AIP Publishing LLC. Date: Jun 1, 2016. URL: http://aip.scitation.org/doi/10.1063/1.4953802 Rights managed by AIP Publishing LL

New Constraints on Neutralino Dark Matter in the Supersymmetric Standard Model

We investigate the prospects for neutralino dark matter within the Supersymmetric Standard Model (SSM) including the constraints from universal soft supersymmetry breaking and radiative breaking of the electroweak symmetry. The latter is enforced by using the one-loop Higgs effective potential which automatically gives the one-loop corrected Higgs boson masses. We perform an exhaustive search of the allowed five-dimensional parameter space and find that the neutralino relic abundance $\Omega_\chi h^2_0$ depends most strongly on the ratio $\xi_0\equiv m_0/m_{1/2}$. For $\xi_0\gg1$ the relic abundance is almost always much too large, whereas for $\xi_0\ll1$ the opposite occurs. For $\xi_0\sim1$ there are wide ranges of the remaining parameters for which $\Omega_\chi\sim1$. We also determine that m_{\tilde q}\gsim250\GeV and m_{\tilde l}\gsim100\GeV are necessary in order to possibly achieve $\Omega_\chi\sim1$. These lower bounds are much weaker than the corresponding ones derived previously when radiative breaking was {\it not} enforced.Comment: 12 pages plus 6 figures (not included), CERN-TH.6584/92, CTP-TAMU-56/92, UAHEP921

Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population

AbstractBackgroundInsulin resistance heightens the risk for type 2 diabetes mellitus and cardiovascular disease. Amelioration of insulin resistance may reduce this risk. The thiazolidinedone class of insulin sensitizers improves insulin action in individuals with insulin-resistant diabetes and nondiabetic individuals. However, there are few reports on the time of onset of such effects independent of reversal of glucotoxicity.ObjectiveThe goal of our study was to test whether the thiazolidinedione pioglitazone has prominent early metabolic effects that can be detected in an obese, nondiabetic, insulin-resistant population.MethodsWe conducted a randomized, double-blind, placebo-controlled, parallel-group trial in men with nondiabetic insulin resistance using a hyperinsulinemic euglycemic clamp technique (at low and high doses of insulin at 10 and 40 mU/m2/min, respectively). The patients were given 30 mg daily oral pioglitazone or placebo for 28 days. Patients underwent a baseline clamp before initiation of treatment, and again at 14 and 28 days of treatment.ResultsCompared with placebo, under high-dose hyperinsulinemia, pioglitazone led to significant increases in glucose disposal rates (GDR) of 1.29 mg/kg/min (90% CI, 0.43–2.15; 39%; P=0.008) that were detectable at 2 weeks of treatment and persisted at 4 weeks of treatment. Under low-dose hyperinsulinemia, significant increases in GDR of 0.40 mg/kg/min (90% CI, 0.17–0.62; 95%; P=0.003) were observed at 4 weeks of treatment. These responses were accompanied by robust suppression of free fatty acids under hyperinsulinemic conditions, and by significant increases in circulating basal total adiponectin at 2 and 4 weeks of treatment.ConclusionsSignificant changes in insulin action across multiple insulin-sensitive tissues can be detected within 2 weeks of initiation of insulin-sensitizing therapy with pioglitazone in obese patients with nondiabetic insulin resistance. ClinicalTrials.gov identifier: NCT01115712

Quantum transport through a DNA wire in a dissipative environment

Electronic transport through DNA wires in the presence of a strong dissipative environment is investigated. We show that new bath-induced electronic states are formed within the bandgap. These states show up in the linear conductance spectrum as a temperature dependent background and lead to a crossover from tunneling to thermal activated behavior with increasing temperature. Depending on the strength of the electron-bath coupling, the conductance at the Fermi level can show a weak exponential or even an algebraic length dependence. Our results suggest a new environmental-induced transport mechanism. This might be relevant for the understanding of molecular conduction experiments in liquid solution, like those recently performed on poly(GC) oligomers in a water buffer (B. Xu et al., Nano Lett 4, 1105 (2004)).Comment: 5 pages, 3 figure

Near-surface meteorology during the Arctic Summer Cloud Ocean Study (ASCOS): evaluation of reanalyses and global climate models

Atmospheric measurements from the Arctic Summer Cloud Ocean Study (ASCOS) are used to evaluate the performance of three atmospheric reanalyses (European Centre for Medium Range Weather Forecasting (ECMWF)-Interim reanalysis, National Center for Environmental Prediction (NCEP)-National Center for Atmospheric Research (NCAR) reanalysis, and NCEP-DOE (Department of Energy) reanalysis) and two global climate models (CAM5 (Community Atmosphere Model 5) and NASA GISS (Goddard Institute for Space Studies) ModelE2) in simulation of the high Arctic environment. Quantities analyzed include near surface meteorological variables such as temperature, pressure, humidity and winds, surface-based estimates of cloud and precipitation properties, the surface energy budget, and lower atmospheric temperature structure. In general, the models perform well in simulating large-scale dynamical quantities such as pressure and winds. Near-surface temperature and lower atmospheric stability, along with surface energy budget terms, are not as well represented due largely to errors in simulation of cloud occurrence, phase and altitude. Additionally, a development version of CAM5, which features improved handling of cloud macro physics, has demonstrated to improve simulation of cloud properties and liquid water amount. The ASCOS period additionally provides an excellent example of the benefits gained by evaluating individual budget terms, rather than simply evaluating the net end product, with large compensating errors between individual surface energy budget terms that result in the best net energy budget

The Influence of Socioeconomic Factors on the Availability and Utilization of Crop Residues as Animal Feeds

The fibrous by-products resulting from crop cultivation constitute a major source of nutrients for animal production in developing countries. On small farms, they form the principal feed of ruminant livestock during the dry seasons. Concerns about inadequate utilization of available feeds have led to the establishment of research programmes to improve the nutritive value and utilization of crop residues as ruminant feed. Despite this, farmer uptake of research findings has been limited. This paper explains why. It argues that the importance of crop residues as feed differs between production systems. Differences in production goals, resource endowments and socioeconomic conditions create different opportunities for the use of crop residues. Consequently, in designing research and extension projects that seek to improve use as livestock feed, it is pertinent to identify the main livestock production systems, farmers' production objectives and resource endowments, and determine the appropriate crop-residue-based diet for each system

Accurate Neutralino Relic Density Computations in Supergravity Models

We investigate the question of the proper thermal averaging of neutralino annihilation amplitudes which possess poles and thresholds, as they impact on the calculated neutralino relic density and therefore on the cosmological viability of supersymmetric models. We focus on two typical resonances, namely the $Z$ boson and the lightest Higgs boson ($h$). In the context of supergravity models with radiative electroweak symmetry breaking, an exploration of the whole parameter space of the model is possible and the overall relevance of these sophisticated analyses can be ascertained. As an example we chose the minimal $SU(5)$ supergravity model since the presence of such poles is essential to obtain a cosmologically acceptable model. We find that the proper thermal averaging is important for individual points in parameter space and that the fraction of cosmologically acceptable points is increased somewhat by the accurate procedure. However, qualitatively the new set of points is very similar to that obtained previously using the usual series approximations to the thermal average. We conclude that all phenomenological analyses based on the previously determined cosmologically allowed set remain valid.Comment: 15 pages, 9 figures (available upon request as uuencoded file or separate ps files), tex (harvmac) CTP-TAMU-14/9

Augmenting the 6-3-5 method with design information

This paper describes a comparative study between the 6-3-5 Method and the ICR Grid. The ICR Grid is an evolved variant of 6-3-5 intended to better integrate information into the concept generation process. Unlike a conventional 6-3-5 process where participants continually sketch concepts, using the ICR Grid (the name derived from its Inform, Create, Reflect activities and structured, grid-like output) participants are additionally required to undertake information search tasks, use specific information items for concept development, and reflect on the merit of concepts as the session progresses. The results indicate that although the quantity of concepts was lower, the use of information had a positive effect in a number of areas, principally the quality and variety of output. Although grounded in the area of product development, this research is applicable to any organisation undertaking idea generation and problem solving. As well as providing insights on the transference of information to concepts, it holds additional interest for studies on the composition and use of digital libraries