Automated Fovea Detection Based on Unsupervised Retinal Vessel Segmentation Method

The Computer Assisted Diagnosis systems could save workloads and give objective diagnostic to ophthalmologists. At first level of automated screening of systems feature extraction is the fundamental step. One of these retinal features is the fovea. The fovea is a small fossa on the fundus, which is represented by a deep-red or red-brown color in color retinal images. By observing retinal images, it appears that the main vessels diverge from the optic nerve head and follow a specific course that can be geometrically modeled as a parabola, with a common vertex inside the optic nerve head and the fovea located along the apex of this parabola curve. Therefore, based on this assumption, the main retinal blood vessels are segmented and fitted to a parabolic model. With respect to the core vascular structure, we can thus detect fovea in the fundus images. For the vessel segmentation, our algorithm addresses the image locally where homogeneity of features is more likely to occur. The algorithm is composed of 4 steps: multi-overlapping windows, local Radon transform, vessel validation, and parabolic fitting. In order to extract blood vessels, sub-vessels should be extracted in local windows. The high contrast between blood vessels and image background in the images cause the vessels to be associated with peaks in the Radon space. The largest vessels, using a high threshold of the Radon transform, determines the main course or overall configuration of the blood vessels which when fitted to a parabola, leads to the future localization of the fovea. In effect, with an accurate fit, the fovea normally lies along the slope joining the vertex and the focus. The darkest region along this line is the indicative of the fovea. To evaluate our method, we used 220 fundus images from a rural database (MUMS-DB) and one public one (DRIVE). The results show that, among 20 images of the first public database (DRIVE) we detected fovea in 85% of them. Also for the MUMS-DB database among 200 images we detect fovea correctly in 83% on them

Stemming the Global Trade in Falsified and Substandard Medicines

Drug safety and quality is an essential assumption of clinical medicine, but there is growing concern that this assumption is not always correct. Poor manufacturing and deliberate fraud occasionally compromises the drug supply in the United States, and the problem is far more common and serious in low- and middle-income countries with weak drug regulatory systems. An Institute of Medicine consensus committee report identified the causes and possible solutions to the problem of falsified and substandard drugs around the world. The vocabulary people use to discuss the problem is itself a concern. The word counterfeit is often used innocuously to describe any drug that is not what it seems, but some NGOs and emerging manufacturing nations object to this term. These groups see hostility to generic pharmaceuticals in a discussion of counterfeit medicines. These groups see hostility to generic pharmaceuticals in a discussion of counterfeit medicines. Precisely speaking, a counterfeit drug infringes on a registered trademark, and trademark infringement in not necessarily a problem of public health consequence. Instead of talking broadly about counterfeit drugs, the WHO and other stakeholders should consider two main categories of drug quality problems. Falsified medicines misrepresent the product’s identity or source or both. Substandard drugs fail to meet the national specifications given in an accepted pharmacopeia or the manufacturer’s dossier. In practice, there is often considerable overlap between categories. There is considerable uncertainty about the size of the falsified and substandard drug market. Improved pharmacovigilance, especially in developing countries, give a better picture of the scope of the problem. In the United States, tighter regulatory controls on the wholesale market and a mandatory drug tracking system would improve drug safety. In developing countries, development finance organizations should invest in small- and medium-sized pharmaceutical manufacturers, and governments should use tools such as franchising, accreditation, low-interest loans, and task shifting to encourage private sector investment in drug retail. Finally, the WHO should work with stakeholders such as the UNODC and the WCO to develop an international code of practice on falsified and substandard drugs

Restating Duty, Breach, and Proximate Cause in Negligence Law: Descriptive Theory and the Rule of Law

The American Law Institute ( ALI ) set out to restate the general common law in the United States in order to promote clarity and certainty in the common law, which were threatened by the ever increasing volume of the decisions of the [different state] courts, establishing new rules or precedents, and the numerous in- stances in which the decisions are irreconcilable. Clarity and certainty in the common law across the United States, of course, re- quires uniformity. Naturally enough, then, the Institute recognized that a Restatement would promote clarity and certainty in the law only insofar as the legal profession accepts the Restatement as prima facie a correct statement of the general law of the United States. The Second and Third Restatements recognized additional objects: to correct errors in earlier restatements, to reflect changes in the common law since earlier restatements, and, in limited circumstances, to promote clearly desirable reform. None of these additional objects can be secured without first achieving uniformity, certainty, and clarity. The original object, therefore, remains of primary importance. This primary object seems to have clear implications for the form of a restatement. Uniformity, clarity, and certainty in the law would be enhanced by a black-letter restatement of the law. The black-letter law could be in the form of specific rules applicable directly to a set of facts, or in the form of standards, with enough specificity to give understandable guidance to the decision-maker called upon to apply the standard to a specific set of facts. The American Law Institute has taken these implications to heart; each restatement is in the form of a set of black-letter rules or standards, with commentary. When there are conflicting specific rules in different states, each restatement adopts one of the rules rather than formulating a legal directive at a higher level of generality that could plausibly describe both of the conflicting rules. In an important sense, then, the primary object of the Restatement project limits the form that any restatement can take, because the goals of uniformity, clarity, and certainty can be achieved only if the law is restated with clarity in a form that can be applied uniformly to yield predictable, certain results

NATO Educational Readiness for the Millennials

The North Atlantic Treaty Organization (NATO), formed in 1949 and described as the most successful alliance in history, is facing change. By 2020, the majority of students in the NATO educational institutions will be Millennium Generation students. To best meet this student group\u27s educational needs, changes to the delivery of educational content may be needed. This study determined how Millennial Generation characteristics may change as Millennials mature, how military service may change Millennials, confirmed the international nature of Millennial characteristics across the 28 nations of NATO and predicted the state of educational technology in 2020. This qualitative study investigated these questions using interviews of subject matter experts from the military and higher education as well as technology companies. With all of these factors considered, the study\u27s author formulated proposals for changes required to be ready to best meet NATO military Millennial educational needs in 2020

Wrongful Life, Wrongful Birth, and Justice in Tort Law

Should those who undertake to aid couples in preventing the birth of a child by contraception or abortion be liable in tort for damages when something goes wrong and an unwanted child is born

Who Decides - Community Safety Conventions at the Heart of Tort Liability

What we need is a uniformly accepted theory that explains the tort liability system in terms of its ultimate social function. The reason we don\u27t have one, I will argue, is that our understanding of the tort liability system has been skewed by an earlier, flawed attempt at descriptive theory. Before embarking on a new search for a descriptive theory, we first ought to formulate a search plan, sometimes called, forbiddingly, a theoretical methodology. Using John Finnis\u27s social science methodology, we can identify the two halves of the focal case of tort liability: intentional battery and negligent infliction of personal injury. Next, history provides the key to an accurate description of negligence liability because it identifies the theoretical origins of the modern unreasonable foreseeable risk explanation of the negligence standard. Once we have identified the origins of that explanation, we can identify the theoretical problem: how to adequately describe a system influenced to some extent by a prior inaccurate theoretical description. The historical and practical inquiries ultimately combine to provide a unified description of battery and negligence liability. This unified description of negligence and battery identifies a common structure to the claims of wrong redressible in the two causes of action. Once we identify the underlying structure of a negligence claim, we can begin to solve the doctrinal puzzles in negligence law

Recent and future drying of the Mediterranean region: anthropogenic forcing, natural variability and social impacts

The Mediterranean region has experienced persistent drying since the middle of the 20th Century and global climate models project further drying in the future as a consequence of increasing greenhouse gases. The Mediterranean region is also known to oscillate between decades of relatively wet and dry conditions due to the strong influence of multidecadal North Atlantic Oscillation (NAO). It is therefore of great importance to understand the relationship between forced long-term drying resulting from human influences and those due to natural variability. To this end, we used observations, reanalyses and comprehensive global climate models in this thesis research. The roles of anthropogenic climate change and internal climate variability in causing the Mediterranean region's late 20th Century extended winter drying trend were examined using 20th Century observations as well as 19 coupled climate models from the CMIP3. The drying was strongly influenced by the robust positive trend in the NAO from the 1960s to the 1990s. Model simulations and observations were used to assess the probable relative roles of radiative forcing and internal variability in explaining the circulation trend that drove much of the precipitation change. It was concluded that the radiatively forced trends were a small fraction of the total observed trends. Instead it was argued that the robust trends in the observed NAO and Mediterranean rainfall during this period were largely due to multidecadal internal variability with a small contribution from the external forcing. Differences between the observed and NAO associated precipitation trends are consistent with those expected as a response to radiative forcing. The radiatively forced trends in circulation and precipitation are expected to strengthen in the current century and these results highlight the importance of their contribution to future precipitation changes in the region. The Mediterranean precipitation climatology and trend were further examined by comparing the newest generation of global climate models (CMIP5) used in the Intergovernmental Panel on Climate Change (IPCC) Fifth Assessment Report, to the previous generation (CMIP3) and to observations over the latter half of the 20th Century for both the summer and winter half years. The observed drying trend since 1950 was predominantly due to winter drying, with very little contribution from the summer. However, in the CMIP5 multimodel mean, the precipitation trend since 1950 is evenly divided throughout the seasonal cycle. This may indicate that in observation, multidecadal internal variability, particularly that associated with the NAO, dominates the wintertime trend. An estimate of the observed externally forced trend showed that winter drying dominated in observations but the spatial patterns were grossly similar to the multimodel mean trend. The similarity was particularly robust in the eastern Mediterranean region, indicating a radiatively forced component being stronger there. These results also revealed modest improvement for the CMIP5 multimodel ensemble in representation of the observed six-month winter and summer climatology. We further explored the detailed mechanisms leading to the NAO-associated precipitation change, such as the role of the change in mean circulation versus that of the storm tracks in the regional moisture budget, which had not been investigated previously. We employed a moisture budget analysis using 15 CMIP5 models and the ERA-Interim Reanalysis to investigate the relationship between the NAO and the various moisture budget terms for the six-month winter and summer. Compared with the ERA-Interim, the models performed well in their simulation of the relationship between the naturally varying NAO and the large-scale moisture budget. Our results indicated that the shift in the midlatitude transient eddies induced modest moisture convergence, rather than divergence, over the Mediterranean under a positive NAO. The reduction in precipitation in this region during a positive NAO was dominated by the mean moisture divergence, which opposed the transient contribution. There were significant differences between the patterns of NAO-induced moisture budget anomaly and changes due to external radiative forcing. Under radiative forcing there was enhanced evaporation over the Mediterranean Sea, Italy and eastern Europe and drying by the shift in the wintertime storms over nearly all of Europe and the Mediterranean. Under a positive phase of the NAO, on the other hand, there was modest reduction in evaporation and wetting by the storms over the Mediterranean, and drying over northern Europe. The dependence of the Mediterranean moisture budget on the NAO was similarly explored in the summer half of the year and in this season the models exhibited more disagreement with observations, but otherwise showed the similar results as winter. The stronger anthropogenic induced drying signal over the eastern Mediterranean provided a basis to examine the possible cause and impact of the recent severe and persistent drought in Syria that occurred directly prior to the uprising of 2011. The drought devastated Syrian agriculture, resulting in food shortages, widespread unemployment, the collapse of rural social structure and a mass migration of agricultural refugees to Syria's urban areas. Anger at the government's failure to ameliorate conditions was one spark for the uprising that evolved into civil war. We found that though droughts occur periodically in Syria due to natural causes it is likely that the recent drought was more extreme due to the century long drying trend caused by increased radiative forcing. It was estimated that the anthropogenic trend made a drought of such severity several times more likely. Droughts as persistent as the recent one are projected to be commonplace in a future warmer world