Local Bureaucrats and Climate Change Adaptation

In local communities across the United States, local government officials – specifically local bureaucrats – are faced with the realities of a changing climate which include severe storms, prolonged droughts, larger and more damaging floods, and more. Simultaneously, the issue of climate change is incredibly polarized in US politics with one side claiming it is not happening (or if it is happening it is not human caused) and the other framing the issue as the direst threat (or close to it) facing the planet. This dissertation examines a empirical puzzle, asking whether and how local bureaucrats respond to the threat of climate change in their communities. I find that many, but not all, local bureaucrats are responding by developing climate adaptation plans and considering policies which might help their communities avoid the consequences of climate change. They are not acting alone, they work with support from the federal or state government, other bureaucrats, or multi-stakeholder organizations which allow them to access resources and gain political support when they would otherwise not have it. Climate change adaptation, like other emergency and disaster management policies, does not garner much attention from local politicians unless there currently is a disaster the community is responding to or recovering from that forces their attention. Throughout this project, I examine how local bureaucrats step out of their conventional role as policy implementors to shape local agendas and formulate policy – policymaking roles often dominated by elected politicians, members of the media, and advocacy organizations. I argue that local bureaucrats occupy the perfect institutional role for shaping the development of climate adaptation in local governments. They have issue-specific knowledge, making them emergency management and climate adaptation experts (or at least the actors with the most expertise of this kind in local government). This often leads to elected officials deferring to bureaucrats when policies and plans need to be written, like emergency management plans, land use plans. When bureaucrats write these plans, they have the opportunity to incorporate climate adaptation provisions. Local bureaucrats also hold institutional knowledge in local governments. They are more likely to know state and federal policies and requirements, which may encourage climate adaptation (e.g. the Obama Administration’s efforts through the Federal Emergency Management Agency (FEMA) to encourage local adaptation policy). Local bureaucrats are also more motivated than elected officials to address climate change. I find that the bureaucrats in this study were aware of the political debates around climate change, but they often adopted a position which separated local adaptation efforts from the polarizing debate around what causes climate change (i.e. who or what is responsible for the problem). This enabled them to address their communities’ needs to adapt without drawing opposition from conservative members of their communities who do not think climate change is happening or caused by human activities. I also address the intergovernmental environment local bureaucrats respond to: specifically, their relationship with their state governments and the federal government. Even though states and the federal government wield significant influence over local governments – mostly through the control of resources – local bureaucrats do not avoid climate adaptation solely because the state government disapproves. A few cases demonstrate that state governments’ and FEMA’s encouragement to address climate adaptation impacted local bureaucrats’ decisions to create adaptation policies. However, it was not the only or the most important influence in local bureaucrats’ decision-making. In sum, this project demonstrates that local bureaucrats are important actors in the development of local climate adaptation policy. Local bureaucrats’ efforts alone are not enough to adapt to climate change, but they are an important first step when politicians cannot or will not act. While only climate adaptation policy was studied in this project, these findings speak to the important role bureaucrats play in creating policy when elected officials do not – either because the issues have low saliences, are highly technical, or are politically polarized

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses from immune checkpoint inhibition in subsets of HCC patients across disease etiologies. The majority of HCC arises in the context of chronic inflammation and from within a fibrotic liver, with many cases associated with hepatitis virus infections, toxins, and fatty liver disease. Many patients also have concomitant cirrhosis which is associated with both local and systemic immune deficiency. Furthermore, the liver is an immunologic organ in itself, which may enhance or suppress the immune response to cancer arising within it. Here, we explore the immunobiology of the liver from its native state to chronic inflammation, fibrosis, cirrhosis and then to cancer, and summarize how this unique microenvironment may affect the response to immunotherapy

Annotated Bibliography of Research in the Teaching of English

Since 2003, RTE has published the annual “Annotated Bibliography of Research in the Teaching of English,” and we are proud to share these curated and annotated citations once again. The goal of the annual bibliography is to offer a synthesis of the research published in the area of English language arts within the past year that may be of interest to RTE readers. Abstracted citations and those featured in the “Other Related Research” sections were published, either in print or online, between June 2019 and June 2020. The bibliography is divided into nine subject area sections. A three-person team of scholars with diverse research interests and background experiences in preK–16 educational settings reviewed and selected the manuscripts for each section using library databases and leading empirical journals. Each team abstracted significant contributions to the body of peer-reviewed studies that addressed the current research questions and concerns in their topic area

Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer. METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients. RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively). CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients

John Clare and place

This chapter tackles issues of place in the self-presentation and critical reception of John Clare, and pursues it across a number of axes. The argument centres on the placing of Clare both socio-economically and ‘naturally’, and limitations exerted upon perceptions of his work. Interrogating criticism this chapter finds a pervasive awkwardness especially in relation to issues of class and labour. It assesses the contemporary ‘placing’ of Clare, and seemingly unavoidable insensitivities to labour and poverty in the history industry, place-naming, and polemical ecocriticism. It assesses the ways Clare represents place – in poverty, in buildings, in nature – and, drawing on Michel de Certeau, considers the tactics Clare uses to negotiate his place. It pursues trajectories to ‘un-place’ Clare: the flight of fame in Clare’s response to Byron; and the flight of an early poem in songbooks and beyond, across the nineteenth century

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

MORBIDITY AND MORTALITY OF CAPTIVE WHOOPING CRANES AT THE INTERNATIONAL CRANE FOUNDATION 1976-2008

Tracking the incidence of morbidity and mortality in captive animal collections helps inform husbandry and preventive medicine programs aimed at improving population health and viability. Carpenter and Derrickson (1982) and Olsen et al. (1997) published summary reports of captive whooping crane (Grus americana) mortality that served to identify key problem areas for the primary breeding flock and potential reintroduction programs involving this endangered species. We expanded on this approach and conducted an initial evaluation of morbidity and mortality factors for whooping cranes at the International Crane Foundation (ICF). The purpose of our study was to identify overrepresented factors and investigate management alternatives to prevent or minimize disease occurrence and mortality, and make recommendations for more effective use of veterinary resources in the future. The medical records of 92 cranes (43 males, 46 females, 3 unknown) were examined for causes of morbidity and mortality from their time of arrival at ICF. Subjects departed the flock due to transfer to other institutions or death. The first brood stock arrived in 1989 from the Patuxent Wildlife Research Center, Laurel, Maryland, in 3 shipments totaling 22 cranes. From 1990 to 1996, 49 whooping crane eggs collected from wild nests in Wood Buffalo National Park (WBNP), Alberta, Canada, were sent to ICF for captive rearing of hatched chicks. The remainder of the records pertained to individuals accessioned since 1976 that were transferred from other institutions or hatched and retained at ICF for the purpose of captive breeding. Records for all groups were reviewed through 2008. The records of all chicks transferred for reintroduction were not included due to their short time in captivity

Enhancing design thinking in instructional technology students

There is growing demand in our society to cultivate creativity and foster innovation. Design thinking has been successfully practiced as an educational framework for supporting innovation in educational and work contexts. However, research on design thinking education that facilitates the acquisition of knowledge related to design process and practices is extremely limited, particularly in educational contexts. This pre-/posttest mixed methods study examined blogging as an instructional approach for supporting design thinking education in an online instructional technology course. An analysis of quantitative and qualitative data revealed an improvement in students\u27 design thinking skills after participating in the course. Students were more comfortable using design practices and processes than their creative abilities. Blogging about design thinking opened the potential for active knowledge construction about design thinking and reflection about personal design practices. However, it also hindered participation of students who were less comfortable with narrative meaning-making afforded through blogging or sharing their ideas on open networks such as blogs.</p

Second‐line chemotherapy in advanced biliary cancers: A retrospective, multicenter analysis of outcomes

BACKGROUND: Though gemcitabine plus platinum chemotherapy is the established first line regimen for advanced biliary tract cancer (ABC), there is no standard second line therapy. We evaluated current practice and outcomes for second line chemotherapy in patients with ABC across three US academic medical centers. METHODS: Institutional registries were reviewed to identify patients who had received second line chemotherapy for ABC from 4/2010 to 3/2015, along with demographics, diagnosis and staging, treatment history, and clinical outcomes. Overall survival from initiation of second line chemotherapy (OS2) was estimated using Kaplan-Meier methods. RESULTS: We identified 198 patients with cholangiocarcinoma (intrahepatic, 61.1% and extrahepatic, 14.1%) and gallbladder carcinoma (24.8%); 52% received at least 3 lines of systemic chemotherapy. The median OS2 11 months (95% CI 8.8-13.1). Median OS2 for intrahepatic cholangiocarcinoma was 13.4 months (95% CI: 10.7-17.8), longer than extrahepatic or gallbladder with mOS2 of 6.8 months (95% CI: 5-10.5) and 9.4 months (95% CI: 7.2-12.3), respectively (p=0.018). The median time to second line treatment failure was 2.2 (95% CI: 1.8-2.7) months, similar across tumor locations (p=0.60). CONCLUSIONS: In this large cohort of ABC patients treated across three academic medical centers after failure of first line chemotherapy, the time to treatment failure on standard therapies was short, though median OS2 was longer than has been reported previously, and over half of patients received additional lines of treatment. This multicenter collaboration represents the largest cohort studied to date of second line chemotherapy in ABC and provides a contemporary benchmark for future clinical trials