124 research outputs found
Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity
[Ag2(9-aca)2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give
[Ag(imidH)2.3(CH3CN)0.7](9-aca) (3), [Ag6(imidH)4(9-aca)6(MeOH)2] (4), {[Ag(1-Me-imid)2]2[Ag4(9-
aca)6]} (5), {[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) and [Ag(apim)](9-aca)·H2O (7) (imidH = imidazole;
1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole).
The mononuclear complex 3, hexanuclear 4–6, and polymeric 7, were all characterised using X-ray
crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial
activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can
survive high doses of the Ag(I) complexes administered in vivo, and a number of the complexes offer
significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells
Evaluation of the efficacy of Alpron disinfectant for dental unit water lines
AIMS: To assess the efficacy of a disinfectant, Alpron, for controlling microbial contamination within dental unit water lines. METHODS: The microbiological quality of water emerging from the triple syringe, high speed handpiece, cup filler and surgery hand wash basin from six dental units was assessed for microbiological total viable counts at 22 degrees C and 37 degrees C before and after treatment with Alpron solutions. RESULTS: The study found that the use of Alpron disinfectant solutions could reduce microbial counts in dental unit water lines to similar levels for drinking water. This effect was maintained in all units for up to six weeks following one course of treatment. In four out of six units the low microbial counts were maintained for 13 weeks. CONCLUSIONS: Disinfectants may have a short term role to play in controlling microbial contamination of dental unit water lines to drinking water quality. However, in the longer term attention must be paid to redesigning dental units to discourage the build up of microbial biofilms
Outcrop Groundwater Prospecting, Drilling, and Well Construction in Hard Rocks in Semi-arid Regions
This chapter presents some recommendations for prospecting, drilling and well construction in hard rocks in semi-arid regions. Considering that these conditions are present in many countries where technology is not always available, the chapter concentrates on the most basic and simple methods to plan where best to drill and maximize success through the direct observation of rock types, weathering and fracturing. The advantage for the geologist and hydrogeologist in an arid or semi-arid environment is that vegetation is normally scarce and the weathering layer thin, allowing a direct view of the rock in circumstances impossible in other climate regions of the world. The close observation of the weathering material, and especially of the fracture network, mainly the fracture density, dip, extension and interconnection, can provide important information for a field hydrogeologist who can then plan the best place for drilling. The most appropriate drilling technique, if available in the area, is rotary percussion, also designated as down-the-hole drilling, with drilling rates that can achieve 100 m per day in normal circumstances. This allows a well to be constructed in about two days, essential in the case of disaster relief. Finally, some information is given about well construction, careful planning of the work, protection to preserve the water quality, avoiding problems of partial or total collapse of the hole during construction or of the well and after completion, and how to avoid direct contact between the surface or sub-surface waters with the aquifer along the walls of the well to protect the well and the aquifer against contamination
Maser radiation from collisionless shocks
Funding: UK Engineering and Physical Sciences Research Council (grant Nos. EP/N014472/1, EP/R004773/1 and EP/N013298/1) and the Science and Technologies Facilities Council of the United Kingdom. F.C. and L.O.S. acknowledge support from the European Research Council (InPairs ERC-2015-AdG 695088) and FCT Portugal (grant No. PD/BD/114307/2016).This paper describes a model of electron energization and cyclotron-maser emission applicable to astrophysical magnetized collisionless shocks. It is motivated by the work of Begelman, Ergun and Rees [Astrophys. J. 625 , 51 (2005)] who argued that the cyclotron-maser instability occurs in localized magnetized collisionless shocks such as those expected in blazar jets. We report on recent research carried out to investigate electron acceleration at collisionless shocks and maser radiation associated with the accelerated electrons. We describe how electrons accelerated by lower-hybrid,waves at collisionless shocks generate cyclotron-maser radiation when the accelerated electrons move into regions of stronger magnetic fields. The electrons are accelerated along the magnetic field and magnetically compressed leading to the formation of an electron velocity distribution having a horseshoe shape due to conservation of the electron magnetic moment. Under certain conditions the horseshoe electron velocity distribution function is unstable to the cyclotron-maser instability [Bingham and Cairns, Phys. Plasmas 7, 3089 (2000); Melrose, Rev. Mod. Plasma Phys. 1 , 5 (2017)].Publisher PDFPeer reviewe
Dyadic adjustment, family coping, body image, quality of life and psychological morbidity in patients with psoriasis and their partners
Background Psoriasis is an incurable and chronic disease
that includes unpredictable periods of remission and relapse
requiring long-term therapy.
Purpose This paper focuses on the relationship among
family coping, psychological morbidity, body image,
dyadic adjustment and quality of life in psoriatic patients
and their partners.
Method One hundred and one patients with psoriasis and
78 partners comprised the sample. They were regular users
of the Dermatology Service of a Central Northern hospital
in Portugal and a private dermatology clinic. Patients with
psoriasis were assessed on anxiety, depression, body image,
quality of life, dyadic adjustment and family coping.
Partners were assessed on the same measures except body
image and quality of life.
Results A positive relationship among dyadic adjustment,
psychological morbidity and family coping in patients and
their partners was found. Also, patients with lower levels of
quality of life had partners with higher levels of depressive
and anxious symptoms. Better dyadic adjustment predicted
family coping in the psoriatic patient. High levels of dyadic
adjustment in patients and low partners’ trait anxiety
predicted better dyadic adjustment in partners.
Conclusion The results highlight the importance of incorporating
family variables in psychological interventions in
psoriasis’ care, particularly family coping and dyadic
adjustment as well as the need for psychological intervention
to focus both on patients and partners
T2K ECAL Test–beam Proposal
The T2K experiment will search for the last unknown element of the neutrino mixing matrix. An crucial component of the near detector for this experiment is the electromagnetic calorimeter which is being built in the UK. Testbeam time is requested to test the full ECAL system, validate calibration techniques, and determine the hadronic and electromagnetic energy scale of the calorimeter
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2. Pathways to detection of non-infectious childhood uveitis in the UK: findings from the UNICORN cohort study
Introduction Prompt detection of childhood uveitis is key to minimising negative impact. From an internationally unique inception cohort, we report pathways to disease detection. UNICORNS is a national childhood non-infectious uveitis study with longitudinal collection of a standardised clinical dataset and patient reported outcomes. Descriptive analysis of baseline characteristics are reported. Amongst 150 recruited children (51% female, 31% non-white ethnicity) age at detection ranged from 2–18yrs (median 10). In 69%, uveitis was diagnosed following onset of symptoms: time from first symptoms to uveitis detection ranged from 0-739days (median 7days), with longer time to detection for those presenting initially to their general practitioner. Non symptomatic children were detected through JIA/other disease surveillance (16%), routine optometry review (5%) or child visual health screening (1%). Commonest underlying diagnoses at uveitis detection were JIA (17%), TINU (9%, higher than pre-pandemic reported UK disease frequency) and sarcoid (1%). 60% had no known systemic disease at uveitis detection. At disease detection, in at least one eye: 34% had structural complications (associated with greater time to detection – 17 days versus 4 days for uncomplicated presentation). The larger relative proportions of children with non-JIA uveitis reported here increase the importance of improving awareness of childhood uveitis amongst the wider clinical communities. There is scope for improvement of pathways to detection. Forthcoming analysis on the full cohort (251 recruited to date across 33 hospitals and 4 nations) will provide nationally representative data on management and the determinants of visual and broader developmental/well-being outcomes
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