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Human-specific transcriptional regulation of CNS development genes by FOXP2.
The signalling pathways controlling both the evolution and development of language in the human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is the only gene implicated in Mendelian forms of human speech and language dysfunction. It has been proposed that the amino acid composition in the human variant of FOXP2 has undergone accelerated evolution, and this two-amino-acid change occurred around the time of language emergence in humans. However, this remains controversial, and whether the acquisition of these amino acids in human FOXP2 has any functional consequence in human neurons remains untested. Here we demonstrate that these two human-specific amino acids alter FOXP2 function by conferring differential transcriptional regulation in vitro. We extend these observations in vivo to human and chimpanzee brain, and use network analysis to identify novel relationships among the differentially expressed genes. These data provide experimental support for the functional relevance of changes in FOXP2 that occur on the human lineage, highlighting specific pathways with direct consequences for human brain development and disease in the central nervous system (CNS). Because FOXP2 has an important role in speech and language in humans, the identified targets may have a critical function in the development and evolution of language circuitry in humans
Microwave Spectroscopy
Contains reports on four research projects.United States Army Signal Corps (Contract DA36-039-sc-87376)Lincoln Laboratory (Purchase Order DDL B-00368)United States ArmyUnited States NavyUnited States Air Force (Contract AF19(604)-7400
The mPower Study, Parkinson Disease Mobile Data Collected Using Researchkit
Current measures of health and disease are often insensitive, episodic, and subjective. Further, these measures generally are not designed to provide meaningful feedback to individuals. The impact of high-resolution activity data collected from mobile phones is only beginning to be explored. Here we present data from mPower, a clinical observational study about Parkinson disease conducted purely through an iPhone app interface. The study interrogated aspects of this movement disorder through surveys and frequent sensor-based recordings from participants with and without Parkinson disease. Benefitting from large enrollment and repeated measurements on many individuals, these data may help establish baseline variability of real-world activity measurement collected via mobile phones, and ultimately may lead to quantification of the ebbs-and-flows of Parkinson symptoms. App source code for these data collection modules are available through an open source license for use in studies of other conditions. We hope that releasing data contributed by engaged research participants will seed a new community of analysts working collaboratively on understanding mobile health data to advance human health
A Gene Expression Fingerprint of C. Elegans Embryonic Motor Neurons
Differential gene expression specifies the highly diverse cell types that constitute the nervous system. With its sequenced genome and simple, well-defined neuroanatomy, the nematode C. elegans is a useful model system in which to correlate gene expression with neuron identity. The UNC-4 transcription factor is expressed in thirteen embryonic motor neurons where it specifies axonal morphology and synaptic function. These cells can be marked with an unc-4::GFP reporter transgene. Here we describe a powerful strategy, Micro-Array Profiling of C. elegans cells (MAPCeL), and confirm that this approach provides a comprehensive gene expression profile of unc-4::GFP motor neurons in vivo.
Study of intrinsic spin and orbital Hall effects in Pt based on a (6s, 6p, 5d) tight-binding model
We study the origin of the intrinsic spin Hall conductivity (SHC) and the
d-orbital Hall conductivity (OHC) in Pt based on a multiorbital tight-binding
model with spin-orbit interaction. We find that the SHC reaches 1000
\hbar/e\Omega cm when the resistivity \rho is smaller than ~10 \mu\Omega cm,
whereas it decreases to 300 \hbar/e\Omega cm when \rho ~ 100 \mu\Omega cm. In
addition, the OHC is still larger than the SHC. The origin of huge SHE and OHE
in Pt is the large ``effective magnetic flux'' that is induced by the
interorbital transition between d_{xy}- and d_{x2-y2}-orbitals with the aid of
the strong spin-orbit interaction.Comment: 5 page
Interpolating self-energy of the infinite-dimensional Hubbard model: Modifying the iterative perturbation theory
We develop an analytical expression for the self-energy of the
infinite-dimensional Hubbard model that is correct in a number of different
limits. The approach represents a generalization of the iterative perturbation
theory to arbitrary fillings. In the weak-coupling regime perturbation theory
to second order in the interaction U is recovered. The theory is exact in the
atomic limit. The high-energy behavior of the self-energy up to order (1/E)**2
and thereby the first four moments of the spectral density are reproduced
correctly. Referring to a standard strong-coupling moment method, we analyze
the limit of strong U. Different modifications of the approach are discussed
and tested by comparing with the results of an exact diagonalization study.Comment: LaTeX, 14 pages, 5 ps figures included, title changed, references
updated, minor change
A Study of the Antiferromagnetic Phase in the Hubbard Model by means of the Composite Operator Method
We have investigated the antiferromagnetic phase of the 2D, the 3D and the
extended Hubbard models on a bipartite cubic lattice by means of the Composite
Operator Method within a two-pole approximation. This approach yields a fully
self-consistent treatment of the antiferromagnetic state that respects the
symmetry properties of both the model and the algebra. The complete phase
diagram, as regards the antiferromagnetic and the paramagnetic phases, has been
drawn. We firstly reported, within a pole approximation, three kinds of
transitions at half-filling: Mott-Hubbard, Mott-Heisenberg and Heisenberg. We
have also found a metal-insulator transition, driven by doping, within the
antiferromagnetic phase. This latter is restricted to a very small region near
half filling and has, in contrast to what has been found by similar approaches,
a finite critical Coulomb interaction as lower bound at half filling. Finally,
it is worth noting that our antiferromagnetic gap has two independent
components: one due to the antiferromagnetic correlations and another coming
from the Mott-Hubbard mechanism.Comment: 20 pages, 37 figures, RevTeX, submitted to Phys. Rev.
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