2,034 research outputs found
Composition profiling InAs quantum dots and wetting layers by atom probe tomography and cross-sectional scanning tunnelling microscopy
This study compares cross-sectional scanning tunnelling microscopy (XSTM) and
atom probe tomography (APT). We use epitaxially grown self-assembled InAs
quantum dots (QDs) in GaAs as an exemplary material with which to compare these
two nanostructural analysis techniques. We studied the composition of the
wetting layer and the QDs, and performed quantitative comparisons of the indium
concentration profiles measured by each method. We show that computational
models of the wetting layer and the QDs, based on experimental data, are
consistent with both analytical approaches. This establishes a link between the
two techniques and shows their complimentary behaviour, an advantage which we
exploit in order to highlight unique features of the examined QD material.Comment: Main article: 8 pages, 6 figures. Appendix: 3 pages, 5 figure
Shape control of QDs studied by cross-sectional scanning tunneling microscopy
In this cross-sectional scanning tunneling microscopy study we investigated
various techniques to control the shape of self-assembled quantum dots (QDs)
and wetting layers (WLs). The result shows that application of an indium flush
during the growth of strained InGaAs/GaAs QD layers results in flattened QDs
and a reduced WL. The height of the QDs and WLs could be controlled by varying
the thickness of the first capping layer. Concerning the technique of antimony
capping we show that the surfactant properties of Sb result in the preservation
of the shape of strained InAs/InP QDs during overgrowth. This could be achieved
by both a growth interrupt under Sb flux and capping with a thin GaAsSb layer
prior to overgrowth of the uncapped QDs. The technique of droplet epitaxy was
investigated by a structural analysis of strain free GaAs/AlGaAs QDs. We show
that the QDs have a Gaussian shape, that the WL is less than 1 bilayer thick,
and that minor intermixing of Al with the QDs takes place.Comment: 7 pages, 10 figure
Shape control of QDs studied by cross-sectional scanning tunneling microscopy
In this cross-sectional scanning tunneling microscopy study we investigated
various techniques to control the shape of self-assembled quantum dots (QDs)
and wetting layers (WLs). The result shows that application of an indium flush
during the growth of strained InGaAs/GaAs QD layers results in flattened QDs
and a reduced WL. The height of the QDs and WLs could be controlled by varying
the thickness of the first capping layer. Concerning the technique of antimony
capping we show that the surfactant properties of Sb result in the preservation
of the shape of strained InAs/InP QDs during overgrowth. This could be achieved
by both a growth interrupt under Sb flux and capping with a thin GaAsSb layer
prior to overgrowth of the uncapped QDs. The technique of droplet epitaxy was
investigated by a structural analysis of strain free GaAs/AlGaAs QDs. We show
that the QDs have a Gaussian shape, that the WL is less than 1 bilayer thick,
and that minor intermixing of Al with the QDs takes place.Comment: 7 pages, 10 figure
Changes in subcellular doxorubicin distribution and cellular accumulation alone can largely account for doxorubicin resistance in SW-1573 lung cancer and MCF-7 breast cancer multidrug resistant tumour cells.
Doxorubicin accumulation defects in multidrug resistant tumour cells are generally small in comparison to the resistance factors. Therefore additional mechanisms must be operative. In this paper we show by a quantitative approach that doxorubicin resistance in several P-glycoprotein-positive non-small cell lung cancer and breast cancer multidrug resistant cell lines can be explained by a summation of accumulation defect and alterations in the efficacy of the drug once present in the cell. This alteration of efficacy was partly due to changes in intracellular drug localisation, characterised by decreased nuclear/cytoplasmic doxorubicin fluorescence ratios (N/C-ratios). N/C-ratios were 2.8-3.6 in sensitive cells, 0.1-0.4 in cells with high (> 70-fold) levels of doxorubicin resistance and 1.2 and 1.9 in cells with low or intermediate (7.5 and 24-fold, respectively) levels of doxorubicin resistance. The change of drug efficacy was reflected by an increase in the total amount of doxorubicin present in the cell at equitoxic (IC50) concentrations. N/C ratios in highly resistant P-glycoprotein-containing cells could be increased with the resistance modifier verapamil to values of 1.3-2.7, a process that was paralleled by a decrease of the cellular doxorubicin amounts present at IC50. At the low to moderate residual levels of resistance, obtained with different concentrations of verapamil, a linear relationship between IC50 and cellular doxorubicin amounts determined at IC50 was found. This shows that at this stage of residual resistance, extra reversal by verapamil should be explained by further increase of drug efficacy rather than by increase of cellular drug accumulation. A similar relationship was found for P-glycoprotein-negative MDR cells with low levels of resistance. Since in these cells N/C ratios could not be altered, verapamil-induced decrease of IC50 must be due to increased drug efficacy by action on as yet unidentified targets. Although the IC50 of sensitive human cells cannot be reached with resistance modifiers, when using these relationships it can be shown by extrapolation that cellular and nuclear doxorubicin amounts at IC50 at complete reversal of resistance were the same as in sensitive cells. It is concluded that doxorubicin resistance factors for multidrug resistant cells can for a large part, and in the case of P-glycoprotein-containing cells probably fully, be accounted for by decreased amounts of drug at nuclear targets, which in turn is characterised by two processes only: decreased cellular accumulation and a shift in the ratio nuclear drug/cytoplasmic drug
EQUIVALENCES BETWEEN STOCHASTIC SYSTEMS
Time-dependent correlation functions of (unstable) particles undergoing
biased or unbiased diffusion, coagulation and annihilation are calculated. This
is achieved by similarity transformations between different stochastic models
and between stochastic and soluble {\em non-stochastic} models. The results
agree with experiments on one-dimensional annihilation-coagulation processes.Comment: 15 pages, Latex. Some corrections made and an appendix adde
General Non-equilibrium Theory of Colloid Dynamics
A non-equilibrium extension of Onsager's canonical theory of thermal
fluctuations is employed to derive a self-consistent theory for the description
of the statistical properties of the instantaneous local concentration profile
n(r,t) of a colloidal liquid in terms of the coupled time evolution equations
of its mean value n(r,t) and of the covariance {\sigma}(r,r';t) \equiv
of its fluctuations {\delta}n(r, t) = n(r, t) -
n(r, t). These two coarse-grained equations involve a local mobility function
b(r, t) which, in its turn, is written in terms of the memory function of the
two-time correlation function C(r, r' ; t, t') \equiv <{\delta}n(r,
t){\delta}n(r',t')>. For given effective interactions between colloidal
particles and applied external fields, the resulting self-consistent theory is
aimed at describing the evolution of a strongly correlated colloidal liquid
from an initial state with arbitrary mean and covariance n^0(r) and
{\sigma}^0(r,r') towards its equilibrium state characterized by the equilibrium
local concentration profile n^(eq)(r) and equilibrium covariance
{\sigma}^(eq)(r,r').
This theory also provides a general theoretical framework to describe
irreversible processes associated with dynamic arrest transitions, such as
aging, and the effects of spatial heterogeneities
Possible experiment to check the reality of a nonequilibrium temperature
An experiment is proposed to check the physical reality of a nonequilibrium absolute temperature previously proposed from theoretical grounds in the framework of extended irreversible thermodynamics
Magnetic Field Effects on Neutron Diffraction in the Antiferromagnetic Phase of
We discuss possible magnetic structures in UPt based on our analysis of
elastic neutron-scattering experiments in high magnetic fields at temperatures
. The existing experimental data can be explained by a single-{\bf q}
antiferromagnetic structure with three independent domains. For modest in-plane
spin-orbit interactions, the Zeeman coupling between the antiferromagnetic
order parameter and the magnetic field induces a rotation of the magnetic
moments, but not an adjustment of the propagation vector of the magnetic order.
A triple-{\bf q} magnetic structure is also consistent with neutron
experiments, but in general leads to a non-uniform magnetization in the
crystal. New experiments could decide between these structures.Comment: 5 figures included in the tex
Some thoughts about nonequilibrium temperature
The main objective of this paper is to show that, within the present
framework of the kinetic theoretical approach to irreversible thermodynamics,
there is no evidence that provides a basis to modify the ordinary Fourier
equation relating the heat flux in a non-equilibrium steady state to the
gradient of the local equilibrium temperature. This fact is supported, among
other arguments, through the kinetic foundations of generalized hydrodynamics.
Some attempts have been recently proposed asserting that, in the presence of
non-linearities of the state variables, such a temperature should be replaced
by the non-equilibrium temperature as defined in Extended Irreversible
Thermodynamics. In the approximations used for such a temperature there is so
far no evidence that sustains this proposal.Comment: 13 pages, TeX, no figures, to appear in Mol. Phy
Superconductivity in heavy-fermion U(Pt,Pd)3 and its interplay with magnetism
The effect of Pd doping on the superconducting phase diagram of the
unconventional superconductor UPt3 has been measured by (magneto)resistance,
specific heat, thermal expansion and magnetostriction. Experiments on single-
and polycrystalline U(Pt1-xPdx)3 for x<= 0.006 show that the superconducting
transition temperatures of the A phase, Tc+, and of the B phase, Tc-, both
decrease, while the splitting DTc increases at a rate of 0.30(2)K/at.%Pd. We
find that DTc(x) correlates with an increase of the weak magnetic moment m(x)
upon Pd doping. This provides further evidence for Ginzburg-Landau scenarios
with magnetism as the symmetry breaking field, i.e. the 2D E representation and
the 1D odd parity model. Only for small splittings DTc is proportional to
m^2(Tc+) (DTc<= 0.05 K) as predicted. The results at larger splittings call for
Ginzburg-Landau expansions beyond 4th order. The tetracritical point in the B-T
plane persists till at least x= 0.002 for B perpendicular to c, while it is
rapidly suppressed for B||c. Upon alloying the A and B phases gain stability at
the expense of the C phase.Comment: 25 pages text (PS), 8 pages with 14 figures (PS), submitted to
Phys.Rev.
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