289 research outputs found
All hormone-producing cell types of the pituitary intermediate and anterior lobes derive from prop1-expressing progenitors
Mutations in PROP1, the most common known cause of combined pituitary hormone deficiency in humans, can result in the progressive loss of all hormones of the pituitary anterior lobe. In mice, Prop1 mutations result in the failure to initiate transcription of Pou1f1 (also known as Pit1) and lack somatotropins, lactotropins, and thyrotropins. The basis for this species difference is unknown. We hypothesized that Prop1 is expressed in a progenitor cell that can develop into all anterior lobe cell types, and not just the somatotropes, thyrotropes, and lactotropes, which are collectively known as the PIT1 lineage. To test this idea, we produced a transgenic Prop1-cre mouse line and conducted lineage-tracing experiments of Prop1-expressing cells. The results reveal that all hormone-secreting cell types of both the anterior and intermediate lobes are descended from Prop1-expressing progenitors. The Prop1-cre mice also provide a valuable genetic reagent with a unique spatial and temporal expression for generating tissue-specific gene rearrangements early in pituitary gland development. We also determined that the minimal essential sequences for reliable Prop1 expression lie within 10 kilobases of the mouse gene and demonstrated that human PROP1 can substitute functionally for mouse Prop1. These studies enhance our understanding of the pathophysiology of disease in patients with PROP1 mutations.Fil: Davis, Shannon W.. University of South Carolina; Estados UnidosFil: Keisler, Jessica L.. University of South Carolina; Estados UnidosFil: Pérez Millán, María Inés. University of Michigan; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schade, Vanessa. University of Michigan; Estados UnidosFil: Camper, Sally A.. University of Michigan; Estados Unido
Randomisation and Derandomisation in Descriptive Complexity Theory
We study probabilistic complexity classes and questions of derandomisation
from a logical point of view. For each logic L we introduce a new logic BPL,
bounded error probabilistic L, which is defined from L in a similar way as the
complexity class BPP, bounded error probabilistic polynomial time, is defined
from PTIME. Our main focus lies on questions of derandomisation, and we prove
that there is a query which is definable in BPFO, the probabilistic version of
first-order logic, but not in Cinf, finite variable infinitary logic with
counting. This implies that many of the standard logics of finite model theory,
like transitive closure logic and fixed-point logic, both with and without
counting, cannot be derandomised. Similarly, we present a query on ordered
structures which is definable in BPFO but not in monadic second-order logic,
and a query on additive structures which is definable in BPFO but not in FO.
The latter of these queries shows that certain uniform variants of AC0
(bounded-depth polynomial sized circuits) cannot be derandomised. These results
are in contrast to the general belief that most standard complexity classes can
be derandomised. Finally, we note that BPIFP+C, the probabilistic version of
fixed-point logic with counting, captures the complexity class BPP, even on
unordered structures
Measuring primordial gravitational waves from CMB B-modes in cosmologies with generalized expansion histories
We evaluate our capability to constrain the abundance of primordial tensor
perturbations in cosmologies with generalized expansion histories in the epoch
of cosmic acceleration. Forthcoming satellite and sub-orbital experiments
probing polarization in the CMB are expected to measure the B-mode power in CMB
polarization, coming from PGWs on the degree scale, as well as gravitational
lensing on arcmin scales; the latter is the main competitor for the measurement
of PGWs, and is directly affected by the underlying expansion history,
determined by the presence of a DE component. In particular, we consider early
DE possible scenarios, in which the expansion history is substantially modified
at the epoch in which the CMB lensing is most relevant. We show that the
introduction of a parametrized DE may induce a variation as large as 30% in the
ratio of the power of lensing and PGWs on the degree scale. We find that
adopting the nominal specifications of upcoming satellite measurements the
constraining power on PGWs is weakened by the inclusion of the extra degrees of
freedom, resulting in a reduction of about 10% of the upper limits on r in
fiducial models with no GWs, as well as a comparable increase in the error bars
in models with non-zero r. Moreover, we find that the inclusion of sub-orbital
CMB experiments, capable of mapping the B-mode power up to the angular scales
affected by lensing, can restore the forecasted performances with a
cosmological constant. Finally, we show how the combination of CMB data with
Type Ia SNe, BAO and Hubble constant allows to constrain simultaneously r and
the DE quantities in the parametrization we consider, consisting of present
abundance and first redshift derivative of the energy density. We compare this
study with results obtained using the forecasted lensing potential measurement
precision from CMB satellite observations, finding consistent results.Comment: 17 pages, 9 figures, accepted for publication by JCAP. Modified
version after the referee's comment
SPT-3G: A Next-Generation Cosmic Microwave Background Polarization Experiment on the South Pole Telescope
We describe the design of a new polarization sensitive receiver, SPT-3G, for
the 10-meter South Pole Telescope (SPT). The SPT-3G receiver will deliver a
factor of ~20 improvement in mapping speed over the current receiver, SPTpol.
The sensitivity of the SPT-3G receiver will enable the advance from statistical
detection of B-mode polarization anisotropy power to high signal-to-noise
measurements of the individual modes, i.e., maps. This will lead to precise
(~0.06 eV) constraints on the sum of neutrino masses with the potential to
directly address the neutrino mass hierarchy. It will allow a separation of the
lensing and inflationary B-mode power spectra, improving constraints on the
amplitude and shape of the primordial signal, either through SPT-3G data alone
or in combination with BICEP-2/KECK, which is observing the same area of sky.
The measurement of small-scale temperature anisotropy will provide new
constraints on the epoch of reionization. Additional science from the SPT-3G
survey will be significantly enhanced by the synergy with the ongoing optical
Dark Energy Survey (DES), including: a 1% constraint on the bias of optical
tracers of large-scale structure, a measurement of the differential Doppler
signal from pairs of galaxy clusters that will test General Relativity on ~200
Mpc scales, and improved cosmological constraints from the abundance of
clusters of galaxies.Comment: 21 pages, 9 figures. To be published in Proceedings of SPIE Volume
9153. Presented at SPIE Astronomical Telescopes + Instrumentation 2014,
conference 915
A Comparison of Maps and Power Spectra Determined from South Pole Telescope and Planck Data
We study the consistency of 150 GHz data from the South Pole Telescope (SPT)
and 143 GHz data from the Planck satellite over the patch of sky covered by the
SPT-SZ survey. We first visually compare the maps and find that the residuals
appear consistent with noise after accounting for differences in angular
resolution and filtering. We then calculate (1) the cross-spectrum between two
independent halves of SPT data, (2) the cross-spectrum between two independent
halves of Planck data, and (3) the cross-spectrum between SPT and Planck data.
We find the three cross-spectra are well-fit (PTE = 0.30) by the null
hypothesis in which both experiments have measured the same sky map up to a
single free calibration parameter---i.e., we find no evidence for systematic
errors in either data set. As a by-product, we improve the precision of the SPT
calibration by nearly an order of magnitude, from 2.6% to 0.3% in power.
Finally, we compare all three cross-spectra to the full-sky Planck power
spectrum and find marginal evidence for differences between the power spectra
from the SPT-SZ footprint and the full sky. We model these differences as a
power law in spherical harmonic multipole number. The best-fit value of this
tilt is consistent among the three cross-spectra in the SPT-SZ footprint,
implying that the source of this tilt is a sample variance fluctuation in the
SPT-SZ region relative to the full sky. The consistency of cosmological
parameters derived from these datasets is discussed in a companion paper.Comment: 15 pages, 9 figures. Published in The Astrophysical Journal. Current
arxiv version matches published versio
A Comparison of Cosmological Parameters Determined from CMB Temperature Power Spectra from the South Pole Telescope and the Planck Satellite
The Planck cosmic microwave background (CMB) temperature data are best fit
with a LCDM model that is in mild tension with constraints from other
cosmological probes. The South Pole Telescope (SPT) 2540 SPT-SZ
survey offers measurements on sub-degree angular scales (multipoles ) with sufficient precision to use as an independent check of
the Planck data. Here we build on the recent joint analysis of the SPT-SZ and
Planck data in \citet{hou17} by comparing LCDM parameter estimates using the
temperature power spectrum from both data sets in the SPT-SZ survey region. We
also restrict the multipole range used in parameter fitting to focus on modes
measured well by both SPT and Planck, thereby greatly reducing sample variance
as a driver of parameter differences and creating a stringent test for
systematic errors. We find no evidence of systematic errors from such tests.
When we expand the maximum multipole of SPT data used, we see low-significance
shifts in the angular scale of the sound horizon and the physical baryon and
cold dark matter densities, with a resulting trend to higher Hubble constant.
When we compare SPT and Planck data on the SPT-SZ sky patch to Planck full-sky
data but keep the multipole range restricted, we find differences in the
parameters and . We perform further checks, investigating
instrumental effects and modeling assumptions, and we find no evidence that the
effects investigated are responsible for any of the parameter shifts. Taken
together, these tests reveal no evidence for systematic errors in SPT or Planck
data in the overlapping sky coverage and multipole range and, at most, weak
evidence for a breakdown of LCDM or systematic errors influencing either the
Planck data outside the SPT-SZ survey area or the SPT data at .Comment: 14 pages, 7 figures. Updated 1 figure and expanded on the reasoning
for fixing the affect of lensing on the power spectrum instead of varying
Alen
The Galactic Halo in Mixed Dark Matter Cosmologies
A possible solution to the small scale problems of the cold dark matter (CDM)
scenario is that the dark matter consists of two components, a cold and a warm
one. We perform a set of high resolution simulations of the Milky Way halo
varying the mass of the WDM particle () and the cosmic dark matter
mass fraction in the WDM component (). The scaling ansatz
introduced in combined analysis of LHC and astroparticle searches postulates
that the relative contribution of each dark matter component is the same
locally as on average in the Universe (e.g. ). Here we find however, that the normalised local WDM fraction ( / ) depends strongly on for 1 keV. Using the scaling ansatz can therefore introduce significant
errors into the interpretation of dark matter searches. To correct this issue a
simple formula that fits the local dark matter densities of each component is
provided.Comment: 19 pages, 10 figures, accepted for publication in JCA
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