69 research outputs found
A cyclonic eddy train and poleward heat transport in the Australian-Antarctic Basin
The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Thu. 5 Dec. / 2F Auditorium , National Institute of Polar Researc
Structure of Meridional Circulation in Southern Ocean captured by long term Mooring
The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Wed. 4 Dec. / Entrance Hall (1st floor) , National Institute of Polar Researc
Development of a gridded Southern Ocean dataset incorporating the effect due to bottom topography
第3回極域科学シンポジウム/第35回極域気水圏シンポジウム 11月29日(木) 国立国語研究所 2階ロビ
Efficient genome editing and its application to conditional genetic analysis in M. polymorpha
Marchantia polymorpha is one of the model species of basal land plants. Although CRISPR/ Cas9-based genome editing has already been demonstrated for this plant, the efficiency was too low to apply to functional analysis. In this study, we show the establishment of CRISPR/Cas9 genome editing vectors with high efficiency for both construction and genome editing. Codon optimization of Cas9 to Arabidopsis achieved over 70% genome editing efficiency at two loci tested. Systematic assessment revealed that guide sequences of 17 nt or shorter dramatically decreased this efficiency. We also demonstrated that a combinatorial use of this system and a floxed complementation construct enabled conditional analysis of a nearly essential gene. This study reports that simple, rapid, and efficient genome editing is feasible with the series of developed vectors
Properties of Antarctic Bottom Water observed by mooring system off Vincennes Bay
第3回極域科学シンポジウム/第35回極域気水圏シンポジウム 11月29日(木) 国立国語研究所 2階多目的
Rapid and persistent freshening of Antarctic Bottom Water in the Australian-Antarctic Basin
第6回極域科学シンポジウム分野横断セッション:[IG] 全球環境変動を駆動する南大洋・南極氷床11月17日(火) 国立極地研究所 2階 大会議
A phase I study of farletuzumab, a humanized anti-folate receptor α monoclonal antibody, in patients with solid tumors
Spatial distribution and risk factors of Schistosoma haematobium and hookworm infections among schoolchildren in Kwale, Kenya
Background: Large-scale schistosomiasis control programs are implemented in regions with diverse social and economic environments. A key epidemiological feature of schistosomiasis is its small-scale heterogeneity. Locally profiling disease dynamics including risk factors associated with its transmission is essential for designing appropriate control programs. To determine spatial distribution of schistosomiasis and its drivers, we examined schoolchildren in Kwale, Kenya. Methodology/Principal findings: We conducted a cross-sectional study of 368 schoolchildren from six primary schools. Soil-transmitted helminths and Schistosoma mansoni eggs in stool were evaluated by the Kato-Katz method. We measured the intensity of Schistosoma haematobium infection by urine filtration. The geometrical mean intensity of S. haematobium was 3.1 eggs/10 ml urine (school range, 1.4?9.2). The hookworm geometric mean intensity was 3.2 eggs/g feces (school range, 0?17.4). Heterogeneity in the intensity of S. haematobium and hookworm infections was evident in the study area. To identify factors associated with the intensity of helminth infections, we utilized negative binomial generalized linear mixed models. The intensity of S. haematobium infection was associated with religion and socioeconomic status (SES), while that of hookworm infection was related to SES, sex, distance to river and history of anthelmintic treatment. Conclusions/Significance: Both S. haematobium and hookworm infections showed micro-geographical heterogeneities in this Kwale community. To confirm and explain our observation of high S. haematobium risk among Muslims, further extensive investigations are necessary. The observed small scale clustering of the S. haematobium and hookworm infections might imply less uniform strategies even at finer scale for efficient utilization of limited resources
ネガティブ感情の機能的側面に関する検討
Negative emotions are beneficial in several domains, including cognition, judgment, motivation, and interpersonal behavior, because they enable individuals’ focus on detailed information about the external world. Nevertheless, most experiments examining the functional aspects of negative emotions have dealt with emotions of sadness, causing their relevance to analytic information processing to be limited to sadness. In the present study, we examine whether the functions of negative emotions are specific to sadness or common to other negative emotions. A total of 109 participants were induced to evoke in them either happiness, sadness, anger, or disgust from their past autobiographical memories. Subsequently, they performed a point distribution task consisting of eight trials; the number of distribution points to the fictitious recipients and reaction time were compared between each emotion. The results showed that the anger group distributed significantly fewer points than the happiness group on the first trial. Although the results were interpretable in terms of the possible functions of each emotion, it was unclear whether the analytic information processing style was indicated as a function specific to sadness or another negative emotion. Further studies are needed to clarify the functionality of emotions, by considering individual differences such as emotional granularity (emotion differentiation) and the nature of the task
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