ANALISIS STRATEGI BISNIS RESTORAN IGAKU DALAM UPAYA MENINGKATKAN PENJUALAN DI MASA PANDEMI

Saat ini DKI Jakarta sedang dilanda pandemi Covid-19 yang menyebabkan penurunan pendapatan secara masif pada sektor pariwisata, termasuk salah satunya adalah Restoran Igaku. Tujuan penelitian ini adalah untuk menganalisis faktor internal dan eksternal dari Restoran Igaku dan menentukan strategi yang paling tepat di masa pandemi ini. Penelitian ini menggunakan metode kualitatif dengan analisis SWOT. Pengambilan data dilakukan melalui wawancara kepada pemilik, kuesioner dan wawancara kepada karyawan dan konsumen, serta melalui observasi dan studi dokumentasi. Data yang diperoleh kemudian di analisis dengan matriks IFE, matriks EFE, matriks IE, matriks SWOT, kuadran SWOT, dan matriks QSPM. Hasil penelitian ini berdasarkan hasil analisis SWOT didapatkan bahwa posisi bisnis berada dalam kuadran I. Dapat diartikan bahwa mendukung strategi agresif atau strategi SO. Terdapat 6 strategi alternatif yang didapatkan dari matriks QSPM, diantaranya prioritas strategi yang paling tinggi adalah untuk mempertahankan kualitas produk, pelayanan, dan fasilitas untuk menjaga loyalitas konsumen. DKI Jakarta is currently being hit by the Covid-19 pandemic which has caused a massive decline in revenue in the tourism sector, one of which is Restoran Igaku. The purpose of this study was to analyze the internal and external factors of Restoran Igaku and determine the most appropriate strategy during this pandemic. This study uses a qualitative method with SWOT analysis. Data were collected through interviews with owners, questionnaires and interviews with employees and consumers, as well as through observation and documentation studies. The data obtained were then analyzed using the IFE matrix, EFE matrix, IE matrix, SWOT matrix, SWOT quadrant, and QSPM matrix. The results of this study based on the results of the SWOT analysis, it was found that the business position was in quadrant I. It can be interpreted that it supports an aggressive strategy or SO strategy. There are 6 alternative strategies obtained from the QSPM matrix, including the highest priority strategy is to maintain product quality, services, and facilities to maintain customer loyalty

Carbon management Index under different land uses of Conoor region of Western ghats in Tamil Nadu

The increased land-use change (LUC) from native lands to other land use at the Conoor region of western ghats in Tamil Nadu has severely declined soil carbon concentration.  Therefore to quantify this decline, Carbon Management Index (CMI) was worked out under major land uses {(Forest (FOR), cropland (CRP), tea plantation (TEA)} using total organic carbon (TOC) and carbon pools under varying degrees of lability {a) NLC (non-labile carbon) b) VLC (very labile carbon) c) LC (labile carbon) d) LLC (less labile carbon)}. Results portray that the carbon pools were significantly (p < 0.05) higher in FOR than in TEA and CRP. The contribution of active pools {(very labile carbon (VLC) and labile carbon (LC)} towards TOC was higher in TEA and CRP, whereas in FOR, the passive pool {(less labile carbon (LLC) and non-labile carbon (NLC)} was higher. TOC (0-45 cm) was concentrated on the surface soils of FOR (32.88 g kg-1), CRP (11.87 g kg-1) and TEA (18.84 g kg-1) and it gradually declined with the increase in depth. The decline in TOC was maximum between 0 – 15 and 15 – 30 cm depth in CRP (30.62%) and FOR (22.17%), whereas it was maximum (37.16%) between 15 -30 and 30 -45 cm depth in TEA. Therefore, LUC spotlights the degradation of carbon pools and its extent was quantified using the carbon management index (CMI). The CMI (0 – 45 cm) recorded at CRP (12.93) and TEA (32.62) signals the need for an implementation of carbon management strategies at Conoor to keep the soils alive and protect biodiversity

Unravelling the carbon pools and carbon stocks under different land uses of Conoor region in Western Ghats of India

Land uses are pivotal in global carbon cycles. The native forest lands possess a greater potential to sequester higher carbon, which can directly address soil quality and climate change problems. Unfortunately, the rapid conversion of forests to other land use over the past few decades has significantly declined the concentration of carbon in the soils.  Therefore, in order to estimate the impact of land-use change (LUC)  on soil carbon status, this present study was attempted under major ecosystems (Forest (FOR), cropland (CRP), tea plantation (TEA)) of Conoor. Results from findings revealed that total organic carbon (TOC) concentration and carbon pools were significantly  (p<0.05) higher in FOR than in CRP and TEA.  TOC (0-45 cm) recorded in FOR, CRP and TEA was 32.88, 11.87 and 18.84 g kg-1 and it decreased along the depth increment. Carbon stock (t ha-1) in FOR, CRP and TEA (0-45cm) was 68.10, 26.04, 42.42. Microbial biomass carbon (MBC) was higher in FOR (283.08 mg kg-1) followed by TEA (94.64 mg kg-1) and CRP (76.22 mg kg-1). The microbial biomass nitrogen (MBN) followed; FOR > TEA > CRP. These results clearly indicate that the LUC has inflicted a greater impact on soil carbon status and its extent was quantified using the land degradation index (LDI). The LDI (0-45 cm) recorded in CRP (-38.65) and TEA (-61.75) signals the need for immediate implementation of carbon management strategies in the CRP and TEA ecosystem to keep the soils of Conoor alive and prevent land degradation

Agronomic biofortification of calcium in cabbage (Brassica Oleracea var capitata) applied with different sources of liming in Ca deficient acidic soil of Coonoor, The Nilgiris (Typic Dystropept)

The human body needs calcium (Ca) to maintain strong bones and teeth and to build a strong structure, helping muscles contract and playing a crucial role in the structural and signalling process. However, low calcium consumption in the diet has related to a variety of disorders in humans, which can have long-term health repercussions. Therefore, this study aimed to evaluate the Ca biofortification capacity of cabbage (Brassica oleracea var capitata) supplied with different Ca-supplying inorganic fertilizer sources at various fixed levels based on soil liming potential grown in open field conditions where four hybrids of cabbage grown in Ca deficient acidic soil. Ca applied as Limestone (CaCO3) (150% and 175% liming potential) and Dolomitic limestone [CaMg(CO3)2]150% liming potential yield high Ca content in cabbage head and foliage (61.3 mg 100 g-1), high glucosinolates content (53.12 mg 100 g-1) and lower oxalate(0.31 mg 100 g-1) that produced firmer head as compared with Ca untreated control which also promoted high market value for Ca biofortified ones. On the other hand, Ca addition leads to lower Fe and Mg content in the cabbage tissues due to an antagonistic effect. All four hybrids of cabbage studied using the agronomic method of biofortification significantly(p≤0.05) improved Ca enrichment (20% more compared to control) without showing any toxicity symptoms making possibility to obtain Ca biofortified cabbage in acidic soil of a hilly ecosystem by application of liming.

Enhancement of fluorescent properties of near-infrared dyes using clickable oligoglycerol dendrons

Near-infrared (NIR) fluorescent dyes are gaining increased attention due to their potential to serve as molecular probes for in vivo imaging. Here, we demonstrate that oligoglycerol dendrons effectively enhance the fluorescence properties of an NIR dye by increasing the solubility in water and the prevention of aggregate formation. First- and second-generation oligoglycerol dendrons were conjugated to an NIR dye via a dipolar-cycloaddition (click) reaction. The two new dye conjugates exhibited enhanced NIR fluorescent emission and considerably higher fluorescent quantum yields than the dye alone. The high photostability measured for one of the oligoglycerol-linked dyes, in comparison to commonly used fluorogenic dyes such as Cy5 and Cy7, was validated using fluorescence microscopy of macrophages

Fluorescence-Quenched Substrates for Live Cell Imaging of Human Glucocerebrosidase Activity

Deficiency of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) leads to abnormal accumulation of glucosyl ceramide in lysosomes and the development of the lysosomal storage disease known as Gaucher’s disease. More recently, mutations in the GBA1 gene that encodes GCase have been uncovered as a major genetic risk factor for Parkinson’s disease (PD). Current therapeutic strategies to increase GCase activity in lysosomes involve enzyme replacement therapy (ERT) and molecular chaperone therapy. One challenge associated with developing and optimizing these therapies is the difficulty in determining levels of GCase activity present within the lysosomes of live cells. Indeed, visualizing the activity of endogenous levels of any glycoside hydrolases, including GCase, has proven problematic within live mammalian cells. Here we describe the successful modular design and synthesis of fluorescence-quenched substrates for GCase. The selection of a suitable fluorophore and quencher pair permits the generation of substrates that allow convenient time-dependent monitoring of endogenous GCase activity within cells as well as localization of activity within lysosomes. These efficiently quenched (∼99.9%) fluorescent substrates also permit assessment of GCase inhibition in live cells by either confocal microscopy or high content imaging. Such substrates should enable improved understanding of GCase in situ as well the optimization of small-molecule chaperones for this enzyme. These findings also suggest routes to generate fluorescence-quenched substrates for other mammalian glycoside hydrolases for use in live cell imaging

Local area networks/ Keisar

xvii. 420 hal.: ill.; 22 cm

Local area networks/ Keisar

xvii. 420 hal.: ill.; 22 cm

Local area networks/ Keisar

xvii. 420 hal.: ill.; 22 cm