IFMIF accelerator conceptual design activities

A Conceptual Design Evaluation (CDE) for the International Fusion Materials Irradiation Facility (IFMIF) began in 1997 and will be completed in 1998, as an international program of the IEA involving the European Community, Japan, Russia and the United States. The IFMIF accelerator system, comprising two 125 mA, 40 MeV deuterium accelerators operating at 175 MHz, is a key element of the IFMIF facility. The objectives and accomplishments of the CDE accelerator studies are outlined

Roadmap for Societal Engagement for Higher Education Institutions

Publicación derivada del siguiente Proyecto Europeo: Higher Education Institution for Societal Engagement. HEISE. http://www.mapsi.eu/heise/Higher education institutions (HEIs) play a key role in educating young people to understand the underlying values in societies and cultures, which create crucial abilities to foster social integration. To succeed in this, the teachers and students of HEIs need novel ways to increase intercultural understanding and social inclusion. Hence, in the project we aim to create a comprehensive educational model grounded in experiential and challenge based learning to increase the higher education institutions’ societal engagement (HEISE).This study was co-funded by the Erasmus+ programme of the European Union within the Strategic Partnership for Higher Education (grant no. 2016-1-EE01-KA203-017334; HEISE project)

Status of the ENUBET Project

The ENUBET Collaboration is designing the first “monitored neutrino beam”: a beam with an unprecedented control of the flux, energy and flavor of neutrinos at source. In particular, ENUBET monitors the νe production mostly by the detection of large angle positrons from three body semileptonic decays of kaons: K+ → e+π0νe. In this paper, we present the status of the Project and the 2018-2019 advances on proton extraction, transfer line, particle identification in the decay tunnel and beam performance

Effects of Submarine-Cable Types and Parameters on Performance of a Future-Scheduled Offshore Wind Farm Connected to Taiwan Power System

Submarine cables are indispensable for offshore wind farms (OWFs) connected to a power grid. The submarine cable can cause certain degrees of impact on the system performance due to its different lengths, characteristics, electrical parameters, etc. This paper employs the power-system simulation software of Power System Simulator for Engineering (PSS/E) for modeling a future-scheduled OWF, i.e., a large-scale doubly-fed induction generator-based OWF of 200 MW, connected to Jang-Bin distribution substation of Taiwan Power System through five feeders, five circuit breakers, two step-up power transformers, a commercial submarine cable, and an underground cable. This paper simulates and compares the electrical quantities of the studied OWF with different operating capacities under various lengths of three types of commercial submarine cable. The transient surge peak voltages at the common bus of the OWF and the bus of Jang-Bin distribution substation subject to the switching of one of the five circuit breakers of the studied OWF under different lengths of the three types of commercial submarine cable are also compared using the power-system simulation software of ATPDraw in Alternative Transients Program (ATP) version of Electromagnetic Transients Program (EMTP). © 1972-2012 IEEE

DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor

HPV-independent head and neck squamous cell carcinoma (HNSCC) is a common cancer globally. The overall response rate to anti-PD1 checkpoint inhibitors (CPIs) in HNSCC is ~16%. One major factor influencing the effectiveness of CPI is the level of tumor infiltrating T cells (TILs). Converting TILlow tumors to TILhigh tumors is thus critical to improve clinical outcome. Here we describe a novel DNA vaccines to facilitate the T-cell infiltration and control tumor growth. We evaluated the expression of target antigens and their respective immunogenicity in HNSCC patients. The efficacy of DNA vaccines targeting two novel antigens were evaluated with or without CPI using a syngeneic model. Most HNSCC patients (43/44) co-expressed MAGED4B and FJX1 and their respective tetramer-specific T cells were in the range of 0.06-0.12%. In a preclinical model, antigen-specific T cells were induced by DNA vaccines and increased T cell infiltration into the tumor, but not MDSC or regulatory T cells. The vaccines inhibited tumor growth and improved the outcome alone and upon combination with anti-PD1 and resulted in tumor clearance in approximately 75% of mice. Pre-existence of MAGED4B and FJX1-reactive T cells in HNSCC patients suggests that these widely expressed antigens are highly immunogenic and could be further expanded by vaccination. The DNA vaccines targeting these antigens induced robust T cell responses and with the anti-PD1 antibody conferring excellent tumor control. This opens up an opportunity for combination immunotherapy that might benefit a wider population of HNSCC patients in an antigen-specific manner