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Cationic palladium allyl complexes [η3-C3H5)Pd(k2P^O)]+SbF6- (2[SbF6],P^O= Ph2P(CH2)2C-(=O)OEt; 3[SbF6], o-Ph2PC6H4C(=O)OEt; 4[SbF6], Ph2P(CH2)2P(=O)Ph2) have been prepared. In all complexes the oxygen donor can be displaced by other ligands such as carbon monoxide and ethylene. Displacement of an ester donor occurs much more readily than displacement of the phosphine oxide function. Above 0°C, the resulting ethylene complexes [η3-C3H5)Pd(C2H4)(k1P~O)]+ react to give (1,2,5-η3)-pent-1-en-5-yl complexes [(H2C=CH(CH2)3Pd(k2P^O)]+. A rate constant of e.g. k(17°C) = (2.27 ± 0.11) × 10-4 s-1 was determined for P,O ≡ Ph2P(CH2)2C(O)OEt by 1H NMR spectroscopy. Using 2-4 as catalyst precursors for ethylene dimerization, the allyl moiety is ultimately cleaved from the metal center as 1,4-pentadiene

10471 Abstracts Collection -- Scalable Visual Analytics

From 21.11. to 26.11.2010, the Dagstuhl Seminar 10471 ``Scalable Visual Analytics\u27\u27 was held in Schloss Dagstuhl~--~Leibniz Center for Informatics. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available

Challenging problems of geospatial visual analytics

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Перевод котельной месторождения в районе г. Нижневартовска на водогрейный режим.

Целью работы является перевод котла ДКВр-10-13 с парового режима работы в водогрейный. В связи с поставленной задачей была подобрана схема перевода парового котла ДКВр-10-13 в водогрейный режим, проведен тепловой, гидравлический и аэродинамический расчет котла, технико-экономический расчет котельной, а так же рассмотрены вопросы безопасности жизнедеятельности работников котельной.The aim is to transfer the boiler DKVr-10-13 with steam mode to hot water. In connection with the task of thermal, hydraulic and aerodynamic calculation of the boiler, technical and economic calculation boiler, as well as the issues of life safety professionals boiler was selected transfer circuit boiler DKVr-10-13 in hot water mode performed

The Effects of Circumcision on the Penis Microbiome

Circumcision is associated with significant reductions in HIV, HSV-2 and HPV infections among men and significant reductions in bacterial vaginosis among their female partners.We assessed the penile (coronal sulci) microbiota in 12 HIV-negative Ugandan men before and after circumcision. Microbiota were characterized using sequence-tagged 16S rRNA gene pyrosequencing targeting the V3-V4 hypervariable regions. Taxonomic classification was performed using the RDP Naïve Bayesian Classifier. Among the 42 unique bacterial families identified, Pseudomonadaceae and Oxalobactericeae were the most abundant irrespective of circumcision status. Circumcision was associated with a significant change in the overall microbiota (PerMANOVA p = 0.007) and with a significant decrease in putative anaerobic bacterial families (Wilcoxon Signed-Rank test p = 0.014). Specifically, two families-Clostridiales Family XI (p = 0.006) and Prevotellaceae (p = 0.006)-were uniquely abundant before circumcision. Within these families we identified a number of anaerobic genera previously associated with bacterial vaginosis including: Anaerococcus spp., Finegoldia spp., Peptoniphilus spp., and Prevotella spp.The anoxic microenvironment of the subpreputial space may support pro-inflammatory anaerobes that can activate Langerhans cells to present HIV to CD4 cells in draining lymph nodes. Thus, the reduction in putative anaerobic bacteria after circumcision may play a role in protection from HIV and other sexually transmitted diseases

Search for W'->tb resonances with left- and right-handed couplings to fermions

We present a search for the production of a heavy gauge boson, W{prime}, that decays to third-generation quarks, by the D0 Collaboration in p{bar p} collisions at {radical}s = 1.96 TeV. We set 95% confidence level upper limits on the production cross section times branching fraction. For the first time, we set limits for arbitrary combinations of left- and right-handed couplings of the W{prime} boson to fermions. For couplings with the same strength as the standard model W boson, we set the following limits for M(W{prime}) > m({nu}{sub R}): M(W{prime}) > 863 GeV for purely left-handed couplings, M(W{prime}) > 885 GeV for purely right-handed couplings, and M(W{prime}) > 916 GeV if both left- and right-handed couplings are present. The limit for right-handed couplings improves for M(W{prime}) < m({nu}{sub R}) to M(W{prime}) > 890 GeV

Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies

Because genetically monomorphic bacterial pathogens harbour little DNA sequence diversity, most current genotyping techniques used to study the epidemiology of these organisms are based on mobile or repetitive genetic elements. Molecular markers commonly used in these bacteria include Clustered Regulatory Short Palindromic Repeats (CRISPR) and Variable Number Tandem Repeats (VNTR). These methods are also increasingly being applied to phylogenetic and population genetic studies. Using the Mycobacterium tuberculosis complex (MTBC) as a model, we evaluated the phylogenetic accuracy of CRISPR- and VNTR-based genotyping, which in MTBC are known as spoligotyping and Mycobacterial Interspersed Repetitive Units (MIRU)-VNTR-typing, respectively. We used as a gold standard the complete DNA sequences of 89 coding genes from a global strain collection. Our results showed that phylogenetic trees derived from these multilocus sequence data were highly congruent and statistically robust, irrespective of the phylogenetic methods used. By contrast, corresponding phylogenies inferred from spoligotyping or 15-loci-MIRU-VNTR were incongruent with respect to the sequence-based trees. Although 24-loci-MIRU-VNTR performed better, it was still unable to detect all strain lineages. The DNA sequence data showed virtually no homoplasy, but the opposite was true for spoligotyping and MIRU-VNTR, which was consistent with high rates of convergent evolution and the low statistical support obtained for phylogenetic groupings defined by these markers. Our results also revealed that the discriminatory power of the standard 24 MIRU-VNTR loci varied by strain lineage. Taken together, our findings suggest strain lineages in MTBC should be defined based on phylogenetically robust markers such as single nucleotide polymorphisms or large sequence polymorphisms, and that for epidemiological purposes, MIRU-VNTR loci should be used in a lineage-dependent manner. Our findings have implications for strain typing in other genetically monomorphic bacteria