Consolidation of complex events via reinstatement in posterior cingulate cortex

It is well-established that active rehearsal increases the efficacy of memory consolidation. It is also known that complex events are interpreted with reference to prior knowledge. However, comparatively little attention has been given to the neural underpinnings of these effects. In healthy adult humans, we investigated the impact of effortful, active rehearsal on memory for events by showing people several short video clips and then asking them to recall these clips, either aloud (Experiment 1) or silently while in an MRI scanner (Experiment 2). In both experiments, actively rehearsed clips were remembered in far greater detail than unrehearsed clips when tested a week later. In Experiment 1, highly similar descriptions of events were produced across retrieval trials, suggesting a degree of semanticization of the memories had taken place. In Experiment 2, spatial patterns of BOLD signal in medial temporal and posterior midline regions were correlated when encoding and rehearsing the same video. Moreover, the strength of this correlation in the posterior cingulate predicted the amount of information subsequently recalled. This is likely to reflect a strengthening of the representation of the video's content. We argue that these representations combine both new episodic information and stored semantic knowledge (or "schemas"). We therefore suggest that posterior midline structures aid consolidation by reinstating and strengthening the associations between episodic details and more generic schematic information. This leads to the creation of coherent memory representations of lifelike, complex events that are resistant to forgetting, but somewhat inflexible and semantic-like in nature

Influential factors of network changes: Dynamic network ties and sustainable startup embeddedness

This research investigated influential factors on changes in networks of startups through a qualitative exploratory case study approach. Based on interviews with founders in Germany and selected stakeholders in entrepreneurial networks combined with a network mapping approach, we developed a framework of influential factors on network changes. In essence, this framework categorizes factors into sustainable resource acquisition, knowledge and skill acquisition, interpersonal factors, and interorganizational factors. Overall, our research contributes to a better understanding of factors that impact network changes by providing a construct with potential for theoretical standardization. In addition, this research offers important managerial implications

NewOX - extending the online exXam system to provide automated formative evaluation of student text-based assignments

A cheat-resistant and foolproof distributed electronic application for summativeassessment of student learning outcomes has been developed and field tested "OnlineeXam" (OX). Good usability experience and feedback features for the students as wellas the lecturers were design goals of the implementation. The field tests showed therobustness of the system in a heterogenic PC pool environment, the ease of use and agood student learning outcome assessment ability (summative assessment) but a lackof a formative impact on the student learning efforts. The incorporation and adoption(for European needs) of a short essay assessment algorithm with a rich user interfaceis proposed

Influential Factors of Network Changes: Dynamic Network Ties and Sustainable Startup Embeddedness

This research investigated influential factors on changes in networks of startups through a qualitative exploratory case study approach. Based on interviews with founders in Germany and selected stakeholders in entrepreneurial networks combined with a network mapping approach, we developed a framework of influential factors on network changes. In essence, this framework categorizes factors into sustainable resource acquisition, knowledge and skill acquisition, interpersonal factors, and interorganizational factors. Overall, our research contributes to a better understanding of factors that impact network changes by providing a construct with potential for theoretical standardization. In addition, this research offers important managerial implications

Communications Biophysics

Contains reports on six research projects

De ontwikkeling van een indicator voor het bodemleven en de bodemkwaliteit van akkergronden op basis van overige aaltjes

Om vast te stellen of de doelen voor duurzamer bodemgebruik worden gehaald, kunnen indicatoren worden gebruikt. Op basis van de wetenschappelijke literatuur bleek dat aaltjes relevant zijn voor het bodemvoedselweb en de functionele biodiversiteit. Ook bleek dat aaltjes goede mogelijkheden bieden om als indicator te worden gebruikt. Om de indicator te kunnen gebruiken moet deze op de een of andere manier iets zeggen over het bodemleven (biodiversiteit) en bodemkwaliteit. Er werd veel tijd besteed aan de implementatie en kwaliteitscontrole van de DNA-testen. Uit eerdere ervaringen bleek namelijk dat het overzetten van DNA-testen uit laboratoriumomstandigheden naar routineomstandigheden niet zo eenvoudig was

Diagnostisches und therapeutisches Vorgehen in der Akutphase nach kranio-zervikalem Beschleunigungstrauma (sog. Schleudertrauma) : Empfehlungen einer schweizerischen Arbeitsgruppe

https://digitalrepository.unm.edu/abq_eh_news/1514/thumbnail.jp

Perceived built environment, health-related quality of life and health care utilization

Previous research has shown that the built environment plays a crucial role for health-related quality of life (HRQoL) and health care utilization. But, there is limited evidence on the independence of this association from lifestyle and social environment. The objective of this cross-sectional study was to investigate these associations, independent of the social environment, physical activity and body mass index (BMI). We used data from the third follow-up of the Swiss study on Air Pollution and Lung and Heart diseases In Adults (SAPALDIA), a population based cohort with associated biobank. Covariate adjusted multiple quantile and polytomous logistic regressions were performed to test associations of variables describing the perceived built environment with HRQoL and health care utilization. Higher HRQoL and less health care utilization were associated with less reported transportation noise annoyance. Higher HRQoL was also associated with greater satisfaction with the living environment and more perceived access to greenspaces. These results were independent of the social environment (living alone and social engagement) and lifestyle (physical activity level and BMI). This study provides further evidence that the built environment should be designed to integrate living and green spaces but separate living and traffic spaces in order to improve health and wellbeing and potentially save health care costs

Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling

While classical cannabinoid receptors are known to crucially impact on myocardial infarction (MI) repair, a function of the cannabinoid-sensitive receptor GPR55 herein is poorly understood. We investigated the role of GPR55 in cardiac physiology and post-MI inflammation and remodelling. Global GPR55-/- and wildtype (WT) mice were basally characterized or assigned to 1, 3 or 28~days permanent MI and subsequently analysed via pro-inflammatory and pro-hypertrophic parameters. GPR55-/- deficiency was basally associated with bradycardia, increased diastolic LV volume and sarcomere length and a subtle inflammatory phenotype. While infarct size and myeloid cell infiltration were unaffected by GPR55 depletion, acute cardiac chemokine production was prolonged post-MI. Concurrently, GPR55-/- hearts exhibited a premature expansion of pro-reparative and phagocytic macrophages paralleled by early up-regulation of extracellular matrix (ECM) factors 3~days post-MI, which could be mimicked by sole haematopoietic GPR55 depletion. Moreover, global GPR55 deficiency mitigated MI-induced foetal gene re-programming and cardiomyocyte hypertrophy, culminating in aggravated LV dilatation and infarct expansion. GPR55 regulates cardiac homeostasis and ischaemia responses by maintaining adequate LV filling and modulating three crucial processes post-MI: wound healing kinetics, cardiomyocyte hypertrophy and maladaptive remodelling