663 research outputs found
Variable damping and coherence in a high-density magnon gas
We report on the fast relaxation behavior of a high-density magnon gas
created by a parametric amplification process. The magnon gas is probed using
the technique of spin-wave packet recovery by parallel parametric pumping.
Experimental results show a damping behavior which is in disagreement with both
the standard model of exponential decay and with earlier observations of
non-linear damping. In particular, the inherent magnon damping is found to
depend upon the presence of the parametric pumping field. A phenomenological
model which accounts for the dephasing of the earlier injected magnons is in
good agreement with the experimental data
The Polytropic Equation of State of Interstellar Gas Clouds
Models are presented for the polytropic equation of state of
self-gravitating, quiescent interstellar gas clouds. A detailed analysis,
including chemistry, thermal balance, and radiative transfer, is performed for
the physical state of the gas as a function of density, metallicity, velocity
field, and background radiation field. It is found that the stiffness of the
equation of state strongly depends on all these physical parameters, and the
adiabatic index varies between 0.2-1.4. The implications for star formation, in
particular at high redshift and in starburst galaxies, and the initial stellar
mass function are discussed.Comment: Accepted by Ap
Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington\u27s Disease
BACKGROUND: Previous studies suggest that Huntingtin, the protein mutated in Huntington\u27s disease (HD), is required for actin based changes in cell morphology, and undergoes stimulus induced targeting to plasma membranes where it interacts with phospholipids involved in cell signaling. The small GTPase Rac1 is a downstream target of growth factor stimulation and PI 3-kinase activity and is critical for actin dependent membrane remodeling.
OBJECTIVE: To determine if Rac1 activity is impaired in HD or regulated by normal Huntingtin.
METHODS: Analyses were performed in differentiated control and HD human stem cells and HD Q140/Q140 knock-in mice. Biochemical methods included SDS-PAGE, western blot, immunoprecipitation, affinity chromatography, and ELISA based Rac activity assays.
RESULTS: Basal Rac1 activity increased following depletion of Huntingtin with Huntingtin specific siRNA in human primary fibroblasts and in human control neuron cultures. Human cells (fibroblasts, neural stem cells, and neurons) with the HD mutation failed to increase Rac1 activity in response to growth factors. Rac1 activity levels were elevated in striatum of 1.5-month-old HD Q140/Q140 mice and in primary embryonic cortical neurons from HD mice. Affinity chromatography analysis of striatal lysates showed that Huntingtin is in a complex with Rac1, p85alpha subunit of PI 3-kinase, and the actin bundling protein alpha-actinin and interacts preferentially with the GTP bound form of Rac1. The HD mutation reduced Huntingtin interaction with p85alpha.
CONCLUSIONS: These findings suggest that Huntingtin regulates Rac1 activity as part of a coordinated response to growth factor signaling and this function is impaired early in HD
Pre-Existing Superbubbles as the Sites of Gamma-Ray Bursts
According to recent models, gamma-ray bursts apparently explode in a wide
variety of ambient densities ranging from ~ 10^{-3} to 30 cm^{-3}. The lowest
density environments seem, at first sight, to be incompatible with bursts in or
near molecular clouds or with dense stellar winds and hence with the
association of gamma-ray bursts with massive stars. We argue that low ambient
density regions naturally exist in areas of active star formation as the
interiors of superbubbles. The evolution of the interior bubble density as a
function of time for different assumptions about the evaporative or
hydrodynamical mass loading of the bubble interior is discussed. We present a
number of reasons why there should exist a large range of inferred afterglow
ambient densities whether gamma-ray bursts arise in massive stars or some
version of compact star coalescence. We predict that many gamma-ray bursts will
be identified with X-ray bright regions of galaxies, corresponding to
superbubbles, rather than with blue localized regions of star formation.
Massive star progenitors are expected to have their own circumstellar winds.
The lack of evidence for individual stellar winds associated with the
progenitor stars for the cases with afterglows in especially low density
environments may imply low wind densities and hence low mass loss rates
combined with high velocities. If gamma-ray bursts are associated with massive
stars, this combination might be expected for compact progenitors with
atmospheres dominated by carbon, oxygen or heavier elements, that is,
progenitors resembling Type Ic supernovae.Comment: 14 pages, no figures, submitted to The Astrophysical Journa
The Probability Distribution Function of Column Density in Molecular Clouds
(Abridged) We discuss the probability distribution function (PDF) of column
density resulting from density fields with lognormal PDFs, applicable to
isothermal gas (e.g., probably molecular clouds). We suggest that a
``decorrelation length'' can be defined as the distance over which the density
auto-correlation function has decayed to, for example, 10% of its zero-lag
value, so that the density ``events'' along a line of sight can be assumed to
be independent over distances larger than this, and the Central Limit Theorem
should be applicable. However, using random realizations of lognormal fields,
we show that the convergence to a Gaussian is extremely slow in the high-
density tail. Thus, the column density PDF is not expected to exhibit a unique
functional shape, but to transit instead from a lognormal to a Gaussian form as
the ratio of the column length to the decorrelation length increases.
Simultaneously, the PDF's variance decreases. For intermediate values of
, the column density PDF assumes a nearly exponential decay. We then
discuss the density power spectrum and the expected value of in actual
molecular clouds. Observationally, our results suggest that may be
inferred from the shape and width of the column density PDF in
optically-thin-line or extinction studies. Our results should also hold for gas
with finite-extent power-law underlying density PDFs, which should be
characteristic of the diffuse, non-isothermal neutral medium (temperatures
ranging from a few hundred to a few thousand degrees). Finally, we note that
for , the dynamic range in column density is small
( a factor of 10), but this is only an averaging effect, with no
implication on the dynamic range of the underlying density distribution.Comment: 13 pages, 7 figures (10 postscript files). Accepted in ApJ.
Eliminated implication that ratio of column length to correlation length
necessarily increases with resolution, and thus that 3D simulations are
unresolved. Added discussion of dependence of autocorrelation function with
parameters of the turbulenc
Motivations and barriers to prosthesis users participation in physical activity, exercise and sport : a review of the literature
The UK will host the Paralympics in 2012 and the Commonwealth Games in 2014 showcasing the talents of elite athletes and aiming to inspire the population to become involved. However, low levels of physical activity (PA) are prevalent: only 40% of men and 28% of women meet the minimum UK recommendations. The limb absent population is no exception. To determine if people with limb amputations are participating in physical activity and sport; whether post-amputation activity levels match pre-amputation levels; and if there are motivations and barriers to participation. Study design: Literature review Five reviewers systematically search of peer reviewed and gray literature in seven bibliographic databases and the Cochrane Library. Results: Following rigorous elimination, 12 articles were finally included in the review and critically appraised. Four themes were identified: components, rehabilitation outcomes, body image and motivations and barriers to participation. People with limb absence are not participating in PA conducive to health benefits, and only a minority participate in exercise and sports. Participation following amputation does not mirror that of pre-amputation levels, and more barriers than motivations exist to adopting and maintaining a physically active lifestyle. This literature review aims to inform those involved in rehabilitation and ongoing care of those with limb absence about what motivates or precludes their participation in physical activity, exercise and sport. Such knowledge could be applied to improving health and well being in this population
Locally finite groups containing a 2 -element with Chernikov centralizer
Suppose that a locally finite group G has a 2-element g with Chernikov centralizer. It is proved that if the involution in âšgâ© has nilpotent centralizer, then G has a soluble subgroup of finite index
Absence of correlation between built-in electric dipole moment and quantum Stark effect in InAs/GaAs self-assembled quantum dots
We report significant deviations from the usual quadratic dependence of the
ground state interband transition energy on applied electric fields in
InAs/GaAs self-assembled quantum dots. In particular, we show that conventional
second-order perturbation theory fails to correctly describe the Stark shift
for electric field below kV/cm in high dots. Eight-band calculations demonstrate this effect is predominantly due to
the three-dimensional strain field distribution which for various dot shapes
and stoichiometric compositions drastically affects the hole ground state. Our
conclusions are supported by two independent experiments.Comment: 4 pages, 4 figure
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The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1
Aim: Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. Methods: PC12 cells and primary cultured brain neurons of rats were examined. pDC316 adenovirus shuttle plasmid was used to mediate the expression of wild-type Htt-18Q-552 or mutant Htt-100Q-552 in PC12 cells. The expression of the autophagy-related proteins LC3 II and Beclin1, as well as the lysosome-associated enzymes Cathepsin B and L was evaluated using Western blotting. The locations of Beclin1 and Htt were observed with immunofluorescence and confocal microscope. Results: Htt552 expression increased the expression of LC3 II, Beclin1, cathepsin B and L in autophagy/lysosomal degradation pathway. Treatment with the autophagy inhibitor 3-MA or the proteasome inhibitors lactacystin and MG-132 increased Htt552 levels in PC12 cells infected with Ad-Htt-18Q-552 or Ad-Htt-100Q-552. The proteasome inhibitor caused a higher accumulation of Htt552-18Q than Htt552-100Q, and the autophagy inhibitor resulted in a higher accumulation of Htt552-100Q than Htt552-18Q. Similar results were observed in primary cultured neurons infected with adenovirus. In Htt552-expressing cells, Beclin1 was redistributed from the nucleus to the cytoplasm. Htt siRNA prevented Beclin1 redistribution in starvation conditions. Blockade of Beclin1 nuclear export by leptomycin B or Beclin1 deficiency caused by RNA interference induced the formation of mHtt552 aggregates. Conclusion: Beclin1 regulates the accumulation of Htt via macroautophagy
Microstructural and physical aspects of heat treated wood, part 1: softwood
Heat treatment of wood is an effective method to improve the dimensional stability and durability against biodegradation. Optimisation of a two-stage heat treatment process at relatively mild conditions (<200°C) and its effect on the anatomical structure of softwoods were investigated by means of a light and scanning electron microscopic analysis. Heat treatment did have an effect on the anatomical structure of wood, although this depends on the wood species considered and on the process method and conditions used. Softwood species with narrow annual rings and/or an abrupt transition from earlywood into latewood were sensitive to tangential cracks in the latewood section. Radial cracks occurred mainly in impermeable wood species such as Norway spruce, caused by large stresses in the wood structure during treatment. Sapwood of treated pine species revealed some damage to parenchyma cells in the rays and epithelial cells around resin canals, whereas this phenomenon has not been noticed in the heartwood section. Treated radiata pine resulted in a very open and permeable wood structure limiting the applications of this species. Broken cell walls perpendicular to the fibre direction resulting in transverse ruptures have been noticed in treated softwood species. This contributes to abrupt fractures of treated wood as observed in bending tests which can lead to considerably different failure behavior after impact or mechanical stress. In some treated softwood species maceration (small cracks between tracheids) was noticed after heat treatment. Heat treatment did not cause damage to the ray parenchyma pit membranes, bordered pits and large window pit membranes; the margo fibrils appeared without damage. Compared to the other softwood timbers tested European grown Douglas fir was the timber that stands heat treatment the best
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