Interferon beta in multiple sclerosis: experience in a British specialist multiple sclerosis centre

Background: The efficacy of interferon beta (IFN beta) is well established in relapsing-remitting multiple sclerosis (MS). However, the use of this drug in clinical practice is complex, especially because it is only partially effective, its long term efficacy and side effects are unknown, its efficacy may be abrogated by the development of neutralising antibodies, compliance is variable, and its cost effectiveness is controversial. Objectives and Methods: Analysis of a prospectively followed up series of 101 MS patients treated with IFN beta was undertaken to: (1) monitor the outcome of IFN beta treatment in clinical practice; (2) compare the immunogenicity of the three commercial IFN beta preparations available; (3) assess the proportion of patients fulfilling the current guidelines of the Association of British Neurologists for stopping IFN beta therapy. Results: During a median treatment period of 26 months (range 2–85), the relapse rate decreased by 41%. Although the reduction in the relapse rate was similar for all three commercial products, none of the Avonex treated patients were relapse free, compared with 19% of the Betaferon treated and 27% of the Rebif treated patients (p=0.02). Neutralising antibodies were not detected in Avonex treated patients (0 of 18), compared with 12 of 32 (38%) Betaferon treated and 10 of 23 (44%) Rebif treated patients (p=0.02). Forty of 101 (40%) patients satisfied the current (2001) Association of British Neurologists criteria for stopping IFN beta treatment at some stage during their treatment. Conclusion: IFN beta is effective in reducing the relapse rate in patients with relapsing-remitting MS in routine clinical practice. However, after a median treatment duration of 26 months, 40% of initially relapsing-remitting MS patients seem to have ongoing disease activity, presenting as disabling relapses or insidious progression

The deactivation of an NH3-SCR Cu-SAPO catalyst upon exposure to non-oxidizing conditions

Abstract A Cu-SAPO catalyst for NH3-SCR applications showed a significant loss of deNOx performance after exposure to oxygen-free conditions. The present work aims at elucidating the causes of the observed progressive deactivation by comparing different experimental procedures for the SCR activity tests. The adoption of an experimental protocol, which avoids the exposure to a non-oxidizing environment, ensured a stable activity of the Cu-SAPO catalyst. Moreover, treatment of the deactivated catalyst with an oxidizing mixture at 550 °C for 5 h enabled to partially recover the deNOx activity

Metallicity and Physical Conditions in the Magellanic Bridge

We present a new analysis of the diffuse gas in the Magellanic Bridge (RA>3h) based on HST/STIS E140M and FUSE spectra of 2 early-type stars lying within the Bridge and a QSO behind it. We derive the column densities of HI (from Ly\alpha), NI, OI, ArI, SiII, SII, and FeII of the gas in the Bridge. Using the atomic species, we determine the first gas-phase metallicity of the Magellanic Bridge, [Z/H]=-1.02+/-0.07 toward one sightline, and -1.7<[Z/H]<-0.9 toward the other one, a factor 2 or more smaller than the present-day SMC metallicity. Using the metallicity and N(HI), we show that the Bridge gas along our three lines of sight is ~70-90% ionized, despite high HI columns, logN(HI)=19.6-20.1. Possible sources for the ongoing ionization are certainly the hot stars within the Bridge, hot gas (revealed by OVI absorption), and leaking photons from the SMC and LMC. From the analysis of CII*, we deduce that the overall density of the Bridge must be low (<0.03-0.1 cm^-3). We argue that our findings combined with other recent observational results should motivate new models of the evolution of the SMC-LMC-Galaxy system.Comment: Accepted for publication in the Ap

Optimization of double pulse pumping for Ni-like Sm x-ray lasers

We report a systematic study of double pulse pumping of the Ni-like Sm x-ray laser at 73 Angstrom, currently the shortest wavelength saturated x-ray laser. It is found that the Sm x-ray laser output can change by orders of magnitude when the intensity ratio of the pumping pulses and their relative delay are varied. Optimum pumping conditions are found and interpreted in terms of a simple model. (C) 1999 American Institute of Physics. [S0021-8979(99)07102-9]

Electron-Ion Recombination on Grains and Polycyclic Aromatic Hydrocarbons

With the high-resolution spectroscopy now available in the optical and satellite UV, it is possible to determine the neutral/ionized column density ratios for several different elements in a single cloud. Assuming ionization equilibrium for each element, one can make several independent determinations of the electron density. For the clouds for which such an analysis has been carried out, these different estimates disagree by large factors, suggesting that some process (or processes) besides photoionization and radiative recombination might play an important role in the ionization balance. One candidate process is collisions of ions with dust grains. Making use of recent work quantifying the abundances of polycyclic aromatic hydrocarbon molecules and other grains in the interstellar medium, as well as recent models for grain charging, we estimate the grain-assisted ion recombination rates for several astrophysically important elements. We find that these rates are comparable to the rates for radiative recombination for conditions typical of the cold neutral medium. Including grain-assisted ion recombination in the ionization equilibrium analysis leads to increased consistency in the various electron density estimates for the gas along the line of sight to 23 Orionis. However, not all of the discrepancies can be eliminated in this way; we speculate on some other processes that might play a role. We also note that grain-assisted recombination of H+ and He+ leads to significantly lower electron fractions than usually assumed for the cold neutral medium.Comment: LaTeX(12 pages, 8 figures, uses emulateapj5.sty, apjfonts.sty); submitted to ApJ; corrected typo

On the Stability of Quasi-Equilibrium Self-Gravitating Configurations in a Tidal Field

The possibility that quasi-equilibrium self-gravitating galaxy-like configurations exist in a tidal field is analyzed in this paper. More specifically, we address the question of how to predict initial configurations modeling galaxies that are able to survive environmental effects in a dense environment for a Hubble time or so, provided thay dynamical friction is neglected. The initial quasi-equilibrium configurations have been built up taking into account the external tidal field produced by the halo. It modifies the escape velocity field of the configuration, compared with isolated configurations. The survival of the configurations as they orbit inside the halos has been studied through N-body simulations. As a general result, it has been found out that the bulk of the models is conserved along 12.5 Gyears of evolution, and that the low rates of mass losses they experience are consistent with those expected when the adiabatic protection hypothesis is at work. So, solutions for galaxy configurations in tidal quasi-equilibrium have been found, showing that tidal stripping in quiescent phases does not seem to be very important, unless that the density of the galaxy environment at its formation had been much lower than that of the galaxy environment at the point of its orbit where the tidal perturbation is maximum. (Abridged)Comment: 36 pages, 7 postscript figures, to be published in Ap