ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013

Acquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%)

Faktor Penentu Keterkendalian Glukosa Darah pada Pasien Diabetes Melitus Tipe II Di Rumah Sakit Bina Husada Cibinong

Diabetes mellitus (DM) merupakan salah satu penyakit kronis, sehingga memerlukan penatalaksanaan yang tepat agar kadar gula darah pasien dapat terkendali serta mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengidentifikasi faktor penentu yang mempengaruhi kadar gula darah pada pasien DM di ruang Poliklinik Penyakit Dalam RS Bina Husada pada 2018. Sampel yang digunakan adalah pasien diabetes melitus tipe 2 yang dilakukan pemeriksaan glukosa darah sewaktu sebanyak 102 orang.Variabel indepenent yang diteliti adalah sosiodemografi pasien (usia, jenis kelamin, pendidikan, pekerjaan, kepemilikan asuransi), aktifitas fisik, faktor biomedik (riwayat keturunan, lama menderita DM, komobiditas), dan faktor konsumsi obat (rasionalitas, pola pemberian obat dan kepatuhan mengkonsumsi obat)  yang diduga mempengaruhi keterkendalian kadar gula darah. Desain penelitian menggunakan studi observasional secara retrospektif dan prospektif.  Analisis data menggunakan uji univariat, bivariat dan multivariat. Hasil penelitian menunjukan bahwa dari 102 orang pasien, terdapat 75 orang (73,5%) glukosa darahnya  terkendali dan 27 orang  (26,5%) glukosa darahnya tidak terkendali. Faktor yang paling dominan menentukan keterkendalian glukosa darah adalah faktor kepatuhan dengan OR 3,873, yang artinya responden yang tidak patuh dalam minum obat akan berpeluang glukosa darahnya  menjadi tidak terkendali 3,9 kali dibanding responden yang patuh setelah dikontrol oleh variabel jenis kelamin, rasionalitas dan komorbiditas

ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013

Acquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%)