Biological Sensors for Solar Ultraviolet Radiation

Solar ultraviolet (UV) radiation is widely known as a genotoxic environmental agent that affects Earth ecosystems and the human population. As a primary consequence of the stratospheric ozone layer depletion observed over the last decades, the increasing UV incidence levels have heightened the concern regarding deleterious consequences affecting both the biosphere and humans, thereby leading to an increase in scientific efforts to understand the role of sunlight in the induction of DNA damage, mutagenesis, and cell death. In fact, the various UV-wavelengths evoke characteristic biological impacts that greatly depend on light absorption of biomolecules, especially DNA, in living organisms, thereby justifying the increasing importance of developing biological sensors for monitoring the harmful impact of solar UV radiation under various environmental conditions. In this review, several types of biosensors proposed for laboratory and field application, that measure the biological effects of the UV component of sunlight, are described. Basically, the applicability of sensors based on DNA, bacteria or even mammalian cells are presented and compared. Data are also presented showing that on using DNA-based sensors, the various types of damage produced differ when this molecule is exposed in either an aqueous buffer or a dry solution. Apart from the data thus generated, the development of novel biosensors could help in evaluating the biological effects of sunlight on the environment. They also emerge as alternative tools for using live animals in the search for protective sunscreen products

Fuzzy control turns 50: 10 years later

In 2015, we celebrate the 50th anniversary of Fuzzy Sets, ten years after the main milestones regarding its applications in fuzzy control in their 40th birthday were reviewed in FSS, see [1]. Ten years is at the same time a long period and short time thinking to the inner dynamics of research. This paper, presented for these 50 years of Fuzzy Sets is taking into account both thoughts. A first part presents a quick recap of the history of fuzzy control: from model-free design, based on human reasoning to quasi-LPV (Linear Parameter Varying) model-based control design via some milestones, and key applications. The second part shows where we arrived and what the improvements are since the milestone of the first 40 years. A last part is devoted to discussion and possible future research topics.Guerra, T.; Sala, A.; Tanaka, K. (2015). Fuzzy control turns 50: 10 years later. Fuzzy Sets and Systems. 281:162-182. doi:10.1016/j.fss.2015.05.005S16218228

A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A

Spiruchostatin A, a potent histone deacetylase inhibitor, was efficiently synthesized from (3S,4R)-4-amino-3-hydroxy-5-methylhexanoic acid utilizing solid-phase peptide elongation with d-cysteine, d-alanine, and (E)-3-hydroxy-7-thio-4-heptenoic acid and solution-phase macrolactonization, followed by intramolecular disulfide formation