Methods composition of physical therapy in disorder of substances exchange in young girls.

В роботі наведено основні складові методів фізичної терапії при порушенні обміну речовин у молоді. Встановлена ефективність розробленої комплексної програми фізичної терапії при надмірній вазі, яку застосовували, протягом 4 місяців в групі у молоді 17-20 років. Доведено, що після експерименту індекс маси тіла у студенток контрольної групи зменшився на 5,7% (р> 0,05), а в експериментальної групи зменшився на 17,4% (р< 0,05), різниця між групами була статистично значима (р<0,05). Запропонована програма фізичної терапії може бути використана з метою профілактики ожиріння та нормалізації обміну речовин у молоді

Generating and transferring grassroots innovations in a multi-actor participatory process

Peer reviewe

One-step synthesis of gold colloids using amidoaminocalix[4]resorcinarenes as reducing and stabilizing agents. Investigation of naproxen binding

© 2017 Elsevier B.V.Amido(dimethylamino) calix[4]resorcinarenes with different substituents on the lower rim (-CH3 (С1), −C5H11 (C5), −C11H23 (C11)) both as reducing and stabilizing agent in an aqueous solution were used for the fabrication of stable gold colloids. Gold colloids are characterized by spectrophotometry, FTIR − spectroscopy, transmission electron microscopy, dynamic light scattering. It is found that increase of the macrocycle's concentration towards HAuCl4 concentration during the synthesis leads to the decrease in the size of formed particles. It is shown that the size of gold nanoparticles (AuNPs) decreases with the increase of the hydrophobicity of the substituents on the macrocycles lower rim (C1@Au − 4–14 nm, C5@Au - 10–11 nm, C11@Au − 7–8 nm). The monolayer packing of the macrocycle molecules on the surface of the metal particle for C1@Au and bilayer − for C5@Au and C11@Au, providing both the stabilization of AuNPs and their solubility in water, are proposed. Temperature and pH variation during the synthesis showed that the optimal synthesis conditions for all kinds of particles C1@Au, C5@Au, C11@Au are spontaneous installed during the synthesis pH (for C1@Au − pH 8.10, C5@Au − pH 8.56, C11@Au − pH 8.63) and the synthesis temperature of the 25 °C. High binding fraction of drug substrate naproxen on the surface of AuNPs modified by C5 and C11 macrocyclic aggregates due to the ordering of the macrocycles on the particle surface and enhancing their receptor ability towards naproxen is defined by fluorescence method

Supramolecular nanoscale systems based on amphiphilic tetramethylensulfonatocalix[4]resorcinarenes and cationic polyelectrolyte with controlled guest molecule binding

© 2016 Informa UK Limited, trading as Taylor & Francis GroupThe water-soluble tetramethylensulfonatocalix[4]resorcinarene with methyl (C1) and pentyl (C5) substitutes on the lower rim forms colloid nanoscale aggregates with poly(diallyldimethylammonium chloride) (PDDA) in aqueous solutions. The size and stability of nanoparticles depend on concentrations of the components and their ratio in the ‘calixarene-polymer’ system. Ternary supramolecular complexes «polymer–macrocycle–guest molecule L-tryptophan (Trp) in conditions of spontaneous pH (3.80 and 4.78 for C1-PDDA and C5-PDDA systems, respectively) in an aqueous solution and in phosphate buffer (pH 7) were investigated by fluorescence method. The addition of the third component – PDDA – to the «non-aggregated C1–Trp» associates leads to the release of Trp in all studied conditions. The possibility of the «binding–release» process of L-tryptophan in «C5–Trp» associates after PDDA addition in the ternary complex is achieved and controlled by the structure of the macrocyclic self-associates and pH conditions

Novel thermoresponsive water-soluble oligomers based on amphiphilic calixresorcinarenes

© 2017 Informa UK Limited, trading as Taylor & Francis Group.Novel water-soluble thermoresponsive oligomers TO1 and TO2 were obtained by reaction of amidoamine tetramethylcalixresorcinarenes (C1) and tetrapentylcalixresorcinarenes (C5) with ethylene glycol diglycidyl ether. The compounds were characterised by 1H and FT-PGSE NMR, FTIR, static light scattering and elemental analysis. The thermoresponsive properties of oligomers were investigated by spectrophotometry, DLS, FT-PGSE NMR and TEM. The cloud points of oligomers (43 °C for TO1 (5 mg/ml) and 41 °C for TO2 (1.2 mg/ml), respectively) were determined. The influence of salts effect on TO2 cloud points was investigated. The binding of anti-inflammatory drug naproxen (Nap) at 20 °C by TO1 and TO2 and its partial release at cloud points of oligomers in aqueous solution are observed using fluorescence and FT-PGSE NMR methods. New example of creating of thermoresponsive macrocyclic systems on the basis of amidoamine calixresorcinarenes with possibility of substrate binding and release under the influence of termo-stimuli in an aqueous solution was shown

Supramolecular nanoscale systems based on amphiphilic tetramethylensulfonatocalix[4]resorcinarenes and cationic polyelectrolyte with controlled guest molecule binding

© 2016 Informa UK Limited, trading as Taylor & Francis Group.The water-soluble tetramethylensulfonatocalix[4]resorcinarene with methyl (C1) and pentyl (C5) substitutes on the lower rim forms colloid nanoscale aggregates with poly(diallyldimethylammonium chloride) (PDDA) in aqueous solutions. The size and stability of nanoparticles depend on concentrations of the components and their ratio in the ‘calixarene-polymer’ system. Ternary supramolecular complexes «polymer–macrocycle–guest molecule L-tryptophan (Trp) in conditions of spontaneous pH (3.80 and 4.78 for C1-PDDA and C5-PDDA systems, respectively) in an aqueous solution and in phosphate buffer (pH 7) were investigated by fluorescence method. The addition of the third component–PDDA–to the «non-aggregated C1–Trp» associates leads to the release of Trp in all studied conditions. The possibility of the «binding–release» process of L-tryptophan in «C5–Trp» associates after PDDA addition in the ternary complex is achieved and controlled by the structure of the macrocyclic self-associates and pH conditions

Round robin comparison on quantitative nanometer scale magnetic field measurements by magnetic force microscopy

Magnetic force microscopy (MFM) can be considered as a standard tool for nano-scale investigation of magnetic domain structures by probing the local stray magnetic field landscape of the measured sample. However, this generally provides only qualitative data. To quantify the stray magnetic fields, the MFM system must be calibrated. To that end, a transfer function (TF) approach was proposed, that, unlike point probe models, fully considers the finite extent of the MFM tip. However, albeit being comprehensive, the TF approach is not yet well established, mainly due to the ambiguities concerning the input parameters and the measurement procedure. Additionally, the calibration process represents an ill-posed problem which requires a regularization that introduces further parameters. In this paper we propose a guideline for quantitative stray field measurements by standard MFM tools in ambient conditions. All steps of the measurement and calibration procedure are detailed, including reference sample and sample under test (SUT) measurements and the data analysis. The suitability of the reference sample used in the present work for calibrated measurements on a sub-micron scale is discussed. A specific regularization approach based on a Pseudo-Wiener Filter is applied and combined with criteria for the numerical determination of a unique regularization parameter. To demonstrate the robustness of such a defined approach, a round robin comparison of magnetic field measurements was conducted by four laboratories. The guideline, the reference sample and the results of the round robin are discussed

New calix[4]arene-based amides - Their synthesis, conformation, complexation

New chiral calix[4]arene-based diol-diamides 1a, 1b, tetraamides 2a, 2b and 7 as well as achiral diamide 3 and tetraamides 4-6 were prepared. The conformation of 1 has been studied in solution by NMR and in solid state by X-ray crystallography. The pinched-cone conformation of the calix[4]arene skeleton in 1 was found to be stabilized by a circular array of hydrogen bonds formed by two phenolic O-H and two amidic N-H bonds at lower rim. Whereas no significant complexation of Na+ was observed in solution for diamides 1 and 3, tetraamides 2, 4, 5, and 6 give strong complexes with Na+ as confirmed by NMR titrations of 2 and 4. The influence of anions and the solvents used on complexation ability of 2 towards Na+ is negligible

Закупка научного оборудования из средств грантов для центров коллективного пользования и уникальных научных установок

This study is devoted to identifying typical problems in the field of scientific equipment procurement in the interests of core shared research facilities and large-scale research facilities and developing approaches to their solution. The paper provides an analysis on the practice of purchasing scientific equipment, conducted on the basis of statistical data obtained from representatives of core shared research facilities and large-scale research facilities that received governmental support in 2019–2021, as well as on the data of a sociological survey. As a result, the hypotheses put forward by the authors about the predominance of foreign-made scientific equipment in the procurement structure, about the decrease in the average cost of purchased equipment in 2019–2021, about the presence of significant unevenness of scientific equipment by subclasses in the procurement structure of scientific equipment, about the presence of similar organizational problems in the field of procurement of scientific equipment. The article suggests a number of approaches to solving the identified problems arising from the formulations of 4 proven hypotheses.Настоящее исследование посвящено выявлению типовых проблем в области организации закупок научного оборудования в интересах центров коллективного пользования и уникальных научных установок, и разработке подходов к их решению. В работе дается анализ практики закупки научного оборудования, проведенный на основе статистических данных, полученных от представителей центров коллективного пользования и уникальных научных установок, получивших государственную поддержку в 2019–2021 гг., а также на данных социологического опроса. В результате нашли свое подтверждение выдвинутые авторами гипотезы о преобладании в структуре закупок научного оборудования иностранного производства, снижении средней стоимости закупленного оборудования в 2019–2021 гг., наличии значимой неравномерности по подклассам научного оборудования в структуре закупок научного оборудования, наличии однотипных проблем организационного характера в области организации закупок научного оборудования. В статье предложен ряд подходов к решению выявленных проблем, вытекающих из формулировок 4 доказанных гипотез

Calibration of multi-layered probes with low/high magnetic moments

We present a comprehensive method for visualisation and quantification of the magnetic stray field of magnetic force microscopy (MFM) probes, applied to the particular case of custom-made multi-layered probes with controllable high/low magnetic moment states. The probes consist of two decoupled magnetic layers separated by a non-magnetic interlayer, which results in four stable magnetic states: ±ferromagnetic (FM) and ±antiferromagnetic (A-FM). Direct visualisation of the stray field surrounding the probe apex using electron holography convincingly demonstrates a striking difference in the spatial distribution and strength of the magnetic flux in FM and A-FM states. In situ MFM studies of reference samples are used to determine the probe switching fields and spatial resolution. Furthermore, quantitative values of the probe magnetic moments are obtained by determining their real space tip transfer function (RSTTF). We also map the local Hall voltage in graphene Hall nanosensors induced by the probes in different states. The measured transport properties of nanosensors and RSTTF outcomes are introduced as an input in a numerical model of Hall devices to verify the probe magnetic moments. The modelling results fully match the experimental measurements, outlining an all-inclusive method for the calibration of complex magnetic probes with a controllable low/high magnetic moment